Research Article
Year 2024,
Volume: 10 Issue: 3, 295 - 302, 04.05.2024
Abstract
Objectives: Frailty is a significant clinical syndrome characterized by greater susceptibility to stressors due to the dysfunction of multiple organ systems, which increases in prevalence with age. This study was performed to investigate relations between frailty and nutritional parameters in patients with chronic kidney disease (CKD).
Methods: This cross-sectional study involved 100 CKD patients aged 50 years or older. Frailty was assessed using the Edmonton Frailty Scale (EFS) and Fried’s Frailty Scale (FFS). The patients nutritional status was assessed using the Mini Nutritional Assessment (MNA) and the routine laboratory tests.
Results: The study included 100 patients, consisting of 41 females and 59 males. The mean age of the participants was 65.3±9.3 years. The median glomerular filtration rate (GFR) of the patients was 23 mL/min/1.73 m2) (min: 3-max: 65). According to the MNA, 15 patients had normal nutritional status, 63 were at risk of malnutrition, and 22 were malnourished. According to the EFS score, four patients were categorized as not frail, 11 as vulnerable, 25 with mild frailty, 21 with moderate frailty, and 39 with severe frailty. According to the FFS score, six patients were non-frail, 30 were classified as pre-frail, and 64 were considered frail.
Conclusions: Frailty and malnutrition in patients with CKD were independently related to all other factors examined in this study. Screening for malnutrition at the early stages in patients with CKD and the appropriate treatment may prevent the development of frailty.
Keywords
References
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Year 2024,
Volume: 10 Issue: 3, 295 - 302, 04.05.2024
Abstract
References
- 1. Kennard A, Glasgow N, Rainsford S, Talaulikar G. Frailty in chronic kidney disease: challenges in nephrology practice. A review of current literature. Intern Med J. 2023;53(4):465-472. doi: 10.1111/imj.15759.
- 2. Weiss CO. Frailty and chronic diseases in older adults. Clin Geriatr Med. 2011;27(1):39-52. doi: 10.1016/j.cger.2010.08.003.
- 3. Lorenzo-López L, Maseda A, de Labra C, Regueiro-Folgueira L, Rodríguez-Villamil JL, Millán-Calenti JC. Nutritional determinants of frailty in older adults: A systematic review. BMC Geriatr. 2017;17(1):108. doi: 10.1186/s12877-017-0496-2.
- 4. Shastri S, Katz R, Rifkin DE, et al. Kidney function and mortality in octogenarians: Cardiovascular Health Study All Stars. J Am Geriatr Soc. 2012;60(7):1201-1207. doi: 10.1111/j.1532-5415.2012.04046.x.
- 5. Rifkin DE, Shlipak MG, Katz R, et al. Rapid kidney function decline and mortality risk in older adults. Arch Intern Med. 2008;168(20):2212-2218. doi: 10.1001/archinte.168.20.2212.
- 6. Buford TW, Anton SD, Judge AR, et al. Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Ageing Res Rev. 2010;9(4):369-833. doi: 10.1016/j.arr.2010.04.004.
- 7. Roshanravan B, Khatri M, Robinson-Cohen C, et al. A prospective study of frailty in nephrology-referred patients with CKD. Am J Kidney Dis. 2012;60(6):912-921. doi: 10.1053/j.ajkd.2012.05.017.
- 8. Andrassy KM. Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Kidney Int. 2013 Sep;84(3):622-623. doi: 10.1038/ki.2013.243.
- 9. Cereda E. Mini nutritional assessment. Curr Opin Clin Nutr Metab Care. 2012;15(1):29-41. doi: 10.1097/MCO.0b013e32834d7647.
- 10. Fabrício-Wehbe SC, Schiaveto FV, Vendrusculo TR, Haas VJ, Dantas RA, Rodrigues RA. Cross-cultural adaptation and validity of the 'Edmonton Frail Scale - EFS' in a Brazilian elderly sample. Rev Lat Am Enfermagem. 2009;17(6):1043-1049. doi: 10.1590/s0104-11692009000600018.
- 11. Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing. 2006;35(5):526-529. doi: 10.1093/ageing/afl041.
- 12. Chang CI, Chan DC, Kuo KN, Hsiung CA, Chen CY. Prevalence and correlates of geriatric frailty in a northern Taiwan community. J Formos Med Assoc. 2011;110(4):247-257. doi: 10.1016/S0929-6646(11)60037-5.
- 13. Grupp C. Frailty bei chronischer Nierenerkrankung [Frailty in chronic kidney disease]. Z Gerontol Geriatr. 2021;54(3):217-222. [Article in German]. doi: 10.1007/s00391-021-01860-4.
- 14. Joosten E, Demuynck M, Detroyer E, Milisen K. Prevalence of frailty and its ability to predict in hospital delirium, falls, and 6-month mortality in hospitalized older patients. BMC Geriatr. 2014;14:1. doi: 10.1186/1471-2318-14-1.
- 15. Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487-1492. doi: 10.1111/j.1532-5415.2012.04054.x.
- 16. Dalrymple LS, Katz R, Rifkin DE, et al. Kidney function and prevalent and incident frailty. Clin J Am Soc Nephrol. 2013;8(12):2091-2099. doi: 10.2215/CJN.02870313.
- 17. Wilhelm-Leen ER, Hall YN, Horwitz RI, Chertow GM. Phase angle, frailty and mortality in older adults. J Gen Intern Med. 2014;29(1):147-154. doi: 10.1007/s11606-013-2585-z.
- 18. Leavey SF, Strawderman RL, Jones CA, Port FK, Held PJ. Simple nutritional indicators as independent predictors of mortality in hemodialysis patients. Am J Kidney Dis. 1998;31(6):997-1006. doi: 10.1053/ajkd.1998.v31.pm9631845.
- 19. Stenvinkel P, Heimbürger O, Lindholm B, Kaysen GA, Bergström J. Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant. 2000;15(7):953-960. doi: 10.1093/ndt/15.7.953.
- 20. Bergström J. Nutrition and mortality in hemodialysis. J Am Soc Nephrol. 1995;6(5):1329-41. doi: 10.1681/ASN.V651329.
- 21. Gibbs J, Cull W, Henderson W, Daley J, Hur K, Khuri SF. Preoperative serum albumin level as a predictor of operative mortality and morbidity: results from the National VA Surgical Risk Study. Arch Surg. 1999;134(1):36-42. doi: 10.1001/archsurg.134.1.36.
- 22. Chao CT, Hsu YH, Chang PY, et al. Simple self-report FRAIL scale might be more closely associated with dialysis complications than other frailty screening instruments in rural chronic dialysis patients. Nephrology (Carlton). 2015;20(5):321-328. doi: 10.1111/nep.12401.
- 23. Shardell M, Hicks GE, Miller RR, et al. Association of low vitamin D levels with the frailty syndrome in men and women. J Gerontol A Biol Sci Med Sci. 2009;64(1):69-75. doi: 10.1093/gerona/gln007.
- 24. Puts MT, Visser M, Twisk JW, Deeg DJ, Lips P. Endocrine and inflammatory markers as predictors of frailty. Clin Endocrinol (Oxf). 2005;63(4):403-411. doi: 10.1111/j.1365-2265.2005.02355.x.
- 25. Matos LC, Tavares MM, Amaral TF. Handgrip strength as a hospital admission nutritional risk screening method. Eur J Clin Nutr. 2007;61(9):1128-1135. doi: 10.1038/sj.ejcn.1602627.
- 26. Wang J, Thornton JC, Kolesnik S, Pierson RN Jr. Anthropometry in body composition. An overview. Ann N Y Acad Sci. 2000;904:317-326. doi: 10.1111/j.1749-6632.2000.tb06474.x.
- 27. Bross R, Chandramohan G, Kovesdy CP, et al. Comparing body composition assessment tests in long-term hemodialysis patients. Am J Kidney Dis. 2010;55(5):885-896. doi: 10.1053/j.ajkd.2009.12.031.
There are 27 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Nefroloji |
| Journal Section | Original Articles |
| Authors | |
| Early Pub Date | March 17, 2024 |
| Publication Date | May 4, 2024 |
| Submission Date | October 16, 2023 |
| Acceptance Date | January 25, 2024 |
| Published in Issue | Year 2024 Volume: 10 Issue: 3 |
e-ISSN: 2149-3189
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