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VACCINATION STATUS AND CLINICAL FEATURES OF HEALTHCARE WORKERS WITH COVID-19 IN A TRAINING AND RESEARCH HOSPITAL

Year 2023, Volume: 8 Issue: 2, 206 - 219, 31.05.2023

Saliha Kazcı Arzu Mirza Meltem Çöl Caner Baysan Çağanay Soysal Elif Yilmaz Barış Örs Gönül Tanır

https://doi.org/10.35232/estudamhsd.1274240

Abstract

It is widely known that a large number of healthcare workers around the world were infected with and lost their lives due to SARS-CoV-2. The study aims to define the sociodemographic characteristics, working conditions, clinical characteristics, and vaccination status of healthcare workers with COVID-19 and to determine the factors affecting clinical characteristics. This cross-sectional study was conducted in a training and research hospital with 681 healthcare workers who had COVID-19 infection between March 11, 2020-March 31, 2022. Participant data was collected under observation using a survey method. Data analysis was performed using the SPSS 25.0 program, Pearson chi square and Fisher's Exact test for categorical variables, Student-t test, and Mann Whitney U test for continuous variables. The average age of the participants was 33.8; 75.6% were women, 20.3% were doctors, and 41.9% were nurses, midwives, and medical officers/technicians. It was reported that the hospital setting was the source of transmission in 44.7% of the cases. The most common symptoms reported were fatigue (77.5%), joint pain (70%), muscle pain (62.1%), and coughing (55.7%). Age, gender, history of chronic disease, and completion of vaccination program significantly affected the symptoms. Long COVID was detected in 28.2% of the participants, and the most persistent symptoms were loss of sense of smell, coughing, and fatigue. Long COVID was detected at a higher rate in women, those with chronic disease, and those who were unvaccinated or did not complete the primary vaccination protocol. While adverse effects were reported in 50.5% of the 2039 vaccine doses administered in total, the most common side effect was pain at the injection site (26%). There were no serious side effects reported. It has been determined that the hospital environment plays a significant role in COVID-19 transmission among healthcare workers, as well as the clinical characteristics, effective factors, and vaccination status of this population. Based on these results, it is recommended that healthcare workers continue to practice caution against transmission and that careful clinical follow-ups of patients with risk are performed.

Keywords

COVID-19 healthcare workers clinic vaccination

References

  • Worldometers [14.08.2022]. Available from: https://www.worldometers.info/coronavirus/.
  • Centers for Disease Control and Prevention. Evidence Used to Update the List of Underlying Medical Conditions Associated with Higher Risk for Severe COVID-19 [19.08.2022]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/underlying-evidence-table.html.
  • Centers for Disease Control and Prevention. Post-COVID Conditions: CDC Science [18.08.2022]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-science.html.
  • Centers for Disease Control and Prevention. Vaccines and Immunizations [18.08.2022]. Available from: https://www.cdc.gov/vaccines/covid-19/clinical-considerations/interim-considerations-us.html.
  • UK Health Security Agency. COVID-19 vaccine surveillance report Week 31 [16.08.2022]. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1096327/Vaccine_surveillance_report_week_31_2022.pdf.
  • World Health Organization. 22.05.2022 [15.08.2022]. Available from: https://www.who.int/director-general/speeches/.
  • Coronavirus (COVID-19) Vaccinations [15.08.2022]. Available from: https://ourworldindata.org/covid-vaccinations.
  • T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü. COVID-19 Temaslı Takibi, Salgın Yönetimi, Evde Hasta İzlemi ve Filyasyon [02 Ekim 2021] [19.08.2022]. Available from: https://covid19.saglik.gov.tr/Eklenti/41623/0/covid-19rehberitemaslitakibievdehastaizlemivefilyasyon-021021pdf.pdf.
  • World Health Organization. Prevention, identification and management of health worker infection in the context of COVID-19 [18.11.2022]. Available from: https://www.who.int/publications/i/item/10665-336265.
  • Madran B KŞ, Beşli Y, Bozkurt İ, Ergönül Ö. The Risk of SARS-CoV-2 Infection Among Healthcare Workers. Infect Dis Clin Microbiol. 2020;2:54-60.
  • Gómez-Ochoa SA, Franco OH, Rojas LZ, Raguindin PF, Roa-Díaz ZM, Wyssmann BM, et al. COVID-19 in Health-Care Workers: A Living Systematic Review and Meta-Analysis of Prevalence, Risk Factors, Clinical Characteristics, and Outcomes. American Journal of Epidemiology. 2021;190(1):161-75.
  • Mostafa A, Kandil S, El-Sayed MH, Girgis S, Hafez H, Yosef M, et al. Universal COVID-19 screening of 4040 health care workers in a resource-limited setting: an Egyptian pilot model in a university with 12 public hospitals and medical centers. International Journal of Epidemiology. 2021;50(1):50-61.
  • Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, et al. Post-acute COVID-19 syndrome. Nature. 2021;27(4):601-15.
  • Chen C, Haupert SR, Zimmermann L, Shi X, Fritsche LG, Mukherjee B. Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review. The Journal of Infectious Diseases. 2022;226(9):1593-607.
  • Moreno-Pérez O, Merino E, Leon-Ramirez JM, Andres M, Ramos JM, Arenas-Jiménez J, et al. Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. The Journal of Infection. 2021;82(3):378-83.
  • World Health Organization. Clinical management of COVID-19: Living guideline, 15 September 2022 [29.12.2022]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Clinical-2022.2.
  • Riad A, Sağıroğlu D, Üstün B, Pokorná A, Klugarová J, Attia S, et al. Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey. Journal of Clinical Medicine. 2021;10(12).
  • Tan AY, Chang CT, Yu YK, Low YX, Razali NFM, Tey SY, et al. Adverse Events Following BNT162b2 mRNA COVID-19 Vaccine Immunization among Healthcare Workers in a Tertiary Hospital in Johor, Malaysia. Vaccines. 2022;10(4).
  • Humer E, Keil T, Stupp C, Schlee W, Wildner M, Heuschmann PU, et al. Associations of country-specific and sociodemographic factors with self-reported COVID-19-related symptoms: Multivariable analysis of data from the CoronaCheck mobile health platform. JMIR public health and surveillance. 2022.
  • Wiegele PN, Kabar I, Kerschke L, Froemmel C, Hüsing-Kabar A, Schmidt H, et al. Symptom Diary-Based Analysis of Disease Course among Patients with Mild Coronavirus Disease, Germany, 2020. Emerging Infectious Diseases. 2021;27(5):1353-61.
  • Xing LH, Xie RM, Ni ZY, Yin XP. Clinical and imaging features of adult COVID-19 patients with or without comorbidities. Asian Journal of Surgery. 2022;45(2):807-9.
  • Strum E, Casagrande Y, Newton K, Unger JB. Healthcare workers benefit from second dose of COVID-19 mRNA vaccine: Effects of partial and full vaccination on sick leave duration and symptoms. Public Health in Practice (Oxford, England). 2022;3:100247.
  • Reynolds MW, Xie Y, Knuth KB, Mack CD, Brinkley E, Toovey S, et al. COVID-19 Vaccination Breakthrough Infections in a Real-World Setting: Using Community Reporters to Evaluate Vaccine Effectiveness. Infection and Drug Resistance. 2022;15:5167-82.
  • Network TH-R. Association of mRNA Vaccination With Clinical and Virologic Features of COVID-19 Among US Essential and Frontline Workers. JAMA. 2022;328(15):1523-33.
  • Wang M, Liu Z, Wang Z, Li K, Tian Y, Lu W, et al. Clinical characteristics of 1139 mild cases of the SARS-CoV-2 Omicron variant infected patients in Shanghai. Journal of Medical Virology.
  • Yang W, Yang S, Wang L, Zhou Y, Xin Y, Li H, et al. Clinical characteristics of 310 SARS-CoV-2 Omicron variant patients and comparison with Delta and Beta variant patients in China. Virologica Sinica. 2022;37(5):704-15.
  • Carvalho-Schneider C, Laurent E, Lemaignen A, Beaufils E, Bourbao-Tournois C, Laribi S, et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2021;27(2):258-63.
  • Pérez-González A, Araújo-Ameijeiras A, Fernández-Villar A, Crespo M, Poveda E. Long COVID in hospitalized and non-hospitalized patients in a large cohort in Northwest Spain, a prospective cohort study. Scientific Reports. 2022;12(1):3369.
  • Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet (London, England). 2021;397(10270):220-32.
  • Hastie CE, Lowe DJ, McAuley A, Winter AJ, Mills NL, Black C, et al. Outcomes among confirmed cases and a matched comparison group in the Long-COVID in Scotland study. Nature Communications. 2022;13(1):5663.

BİR EĞİTİM VE ARAŞTIRMA HASTANESİNDE COVID-19 GEÇİREN SAĞLIK ÇALIŞANLARINDA AŞILANMA DURUMU VE KLİNİK ÖZELLİKLER

Year 2023, Volume: 8 Issue: 2, 206 - 219, 31.05.2023

Saliha Kazcı Arzu Mirza Meltem Çöl Caner Baysan Çağanay Soysal Elif Yilmaz Barış Örs Gönül Tanır

https://doi.org/10.35232/estudamhsd.1274240

Abstract

Dünya çapında çok sayıda sağlık çalışanının SARS-CoV-2 ile enfekte olduğu ve yaşamını kaybettiği bilinmektedir. Çalışmada, COVID-19 geçirmiş sağlık çalışanlarının sosyodemografik özelliklerini, çalışma koşullarını, klinik özelliklerini, aşılanma durumunu tanımlamak ve klinik özelliklere etkili faktörleri saptamak amaçlandı. Araştırma kesitsel tipte olup bir eğitim ve araştırma hastanesinde 11 Mart 2020-31 Mart 2022 tarihleri arasında COVID-19 enfeksiyonu geçirmiş 681 sağlık çalışanı ile gerçekleştirildi. Katılımcı bilgileri gözlem altında anket yöntemi ile toplandı. Verilerin analizi SPSS 25.0 programında, kategorik değişkenlerde Pearson ki-kare ve Fisher’in Exact testi, sürekli değişkenlerde Student-t testi ve Mann Whitney U testi kullanılarak yapıldı. Katılımcıların yaş ortalaması 33,8, %75,6’sı kadın, %20,3’ü doktor, %41,9’u hemşire, ebe, sağlık memuru/teknikerdi. Bulaş kaynağı olarak vakaların %44,7’sinde hastane olduğu bildirildi. En sık görülen semptomlar halsizlik (%77,5), eklem ağrısı (%70), kas ağrısı (%62,1), öksürük (%55,7) olarak bulundu. Yaş, cinsiyet, kronik hastalık varlığı, aşı şemasını tamamlamış olma durumu, semptomları anlamlı ölçüde etkiledi. Uzamış COVID katılımcıların %28,2’sinde saptandı ve en çok devam eden semptomlar koku kaybı, öksürük, halsizlik oldu. Kadınlarda, kronik hastalığı olanlarda ve aşısız veya primer şemayı tamamlamamış olanlarda uzamış COVID daha yüksek oranda saptandı. Toplam 2039 doz aşıdan %50,5’inde yan etki bildirilirken, en sık gelişen yan etki enjeksiyon bölgesinde ağrı (%26) idi. Ciddi yan etki bildirilmedi. COVID-19 geçiren sağlık çalışanlarında hastane ortamının bulaşta önemli olduğu ve bu gruptaki klinik özellikler, etkili faktörler ve aşılanma durumu belirlenmiştir. Bu sonuçlara dayanarak, sağlık çalışanlarında korunmaya devam edilmesi ve riskli kişilerin klinik takiplerinin dikkatle yapılması önerilir

Keywords

COVID-19 sağlık çalışanı klinik Aşılanma

References

  • Worldometers [14.08.2022]. Available from: https://www.worldometers.info/coronavirus/.
  • Centers for Disease Control and Prevention. Evidence Used to Update the List of Underlying Medical Conditions Associated with Higher Risk for Severe COVID-19 [19.08.2022]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/underlying-evidence-table.html.
  • Centers for Disease Control and Prevention. Post-COVID Conditions: CDC Science [18.08.2022]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-science.html.
  • Centers for Disease Control and Prevention. Vaccines and Immunizations [18.08.2022]. Available from: https://www.cdc.gov/vaccines/covid-19/clinical-considerations/interim-considerations-us.html.
  • UK Health Security Agency. COVID-19 vaccine surveillance report Week 31 [16.08.2022]. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1096327/Vaccine_surveillance_report_week_31_2022.pdf.
  • World Health Organization. 22.05.2022 [15.08.2022]. Available from: https://www.who.int/director-general/speeches/.
  • Coronavirus (COVID-19) Vaccinations [15.08.2022]. Available from: https://ourworldindata.org/covid-vaccinations.
  • T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü. COVID-19 Temaslı Takibi, Salgın Yönetimi, Evde Hasta İzlemi ve Filyasyon [02 Ekim 2021] [19.08.2022]. Available from: https://covid19.saglik.gov.tr/Eklenti/41623/0/covid-19rehberitemaslitakibievdehastaizlemivefilyasyon-021021pdf.pdf.
  • World Health Organization. Prevention, identification and management of health worker infection in the context of COVID-19 [18.11.2022]. Available from: https://www.who.int/publications/i/item/10665-336265.
  • Madran B KŞ, Beşli Y, Bozkurt İ, Ergönül Ö. The Risk of SARS-CoV-2 Infection Among Healthcare Workers. Infect Dis Clin Microbiol. 2020;2:54-60.
  • Gómez-Ochoa SA, Franco OH, Rojas LZ, Raguindin PF, Roa-Díaz ZM, Wyssmann BM, et al. COVID-19 in Health-Care Workers: A Living Systematic Review and Meta-Analysis of Prevalence, Risk Factors, Clinical Characteristics, and Outcomes. American Journal of Epidemiology. 2021;190(1):161-75.
  • Mostafa A, Kandil S, El-Sayed MH, Girgis S, Hafez H, Yosef M, et al. Universal COVID-19 screening of 4040 health care workers in a resource-limited setting: an Egyptian pilot model in a university with 12 public hospitals and medical centers. International Journal of Epidemiology. 2021;50(1):50-61.
  • Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, et al. Post-acute COVID-19 syndrome. Nature. 2021;27(4):601-15.
  • Chen C, Haupert SR, Zimmermann L, Shi X, Fritsche LG, Mukherjee B. Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review. The Journal of Infectious Diseases. 2022;226(9):1593-607.
  • Moreno-Pérez O, Merino E, Leon-Ramirez JM, Andres M, Ramos JM, Arenas-Jiménez J, et al. Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. The Journal of Infection. 2021;82(3):378-83.
  • World Health Organization. Clinical management of COVID-19: Living guideline, 15 September 2022 [29.12.2022]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Clinical-2022.2.
  • Riad A, Sağıroğlu D, Üstün B, Pokorná A, Klugarová J, Attia S, et al. Prevalence and Risk Factors of CoronaVac Side Effects: An Independent Cross-Sectional Study among Healthcare Workers in Turkey. Journal of Clinical Medicine. 2021;10(12).
  • Tan AY, Chang CT, Yu YK, Low YX, Razali NFM, Tey SY, et al. Adverse Events Following BNT162b2 mRNA COVID-19 Vaccine Immunization among Healthcare Workers in a Tertiary Hospital in Johor, Malaysia. Vaccines. 2022;10(4).
  • Humer E, Keil T, Stupp C, Schlee W, Wildner M, Heuschmann PU, et al. Associations of country-specific and sociodemographic factors with self-reported COVID-19-related symptoms: Multivariable analysis of data from the CoronaCheck mobile health platform. JMIR public health and surveillance. 2022.
  • Wiegele PN, Kabar I, Kerschke L, Froemmel C, Hüsing-Kabar A, Schmidt H, et al. Symptom Diary-Based Analysis of Disease Course among Patients with Mild Coronavirus Disease, Germany, 2020. Emerging Infectious Diseases. 2021;27(5):1353-61.
  • Xing LH, Xie RM, Ni ZY, Yin XP. Clinical and imaging features of adult COVID-19 patients with or without comorbidities. Asian Journal of Surgery. 2022;45(2):807-9.
  • Strum E, Casagrande Y, Newton K, Unger JB. Healthcare workers benefit from second dose of COVID-19 mRNA vaccine: Effects of partial and full vaccination on sick leave duration and symptoms. Public Health in Practice (Oxford, England). 2022;3:100247.
  • Reynolds MW, Xie Y, Knuth KB, Mack CD, Brinkley E, Toovey S, et al. COVID-19 Vaccination Breakthrough Infections in a Real-World Setting: Using Community Reporters to Evaluate Vaccine Effectiveness. Infection and Drug Resistance. 2022;15:5167-82.
  • Network TH-R. Association of mRNA Vaccination With Clinical and Virologic Features of COVID-19 Among US Essential and Frontline Workers. JAMA. 2022;328(15):1523-33.
  • Wang M, Liu Z, Wang Z, Li K, Tian Y, Lu W, et al. Clinical characteristics of 1139 mild cases of the SARS-CoV-2 Omicron variant infected patients in Shanghai. Journal of Medical Virology.
  • Yang W, Yang S, Wang L, Zhou Y, Xin Y, Li H, et al. Clinical characteristics of 310 SARS-CoV-2 Omicron variant patients and comparison with Delta and Beta variant patients in China. Virologica Sinica. 2022;37(5):704-15.
  • Carvalho-Schneider C, Laurent E, Lemaignen A, Beaufils E, Bourbao-Tournois C, Laribi S, et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2021;27(2):258-63.
  • Pérez-González A, Araújo-Ameijeiras A, Fernández-Villar A, Crespo M, Poveda E. Long COVID in hospitalized and non-hospitalized patients in a large cohort in Northwest Spain, a prospective cohort study. Scientific Reports. 2022;12(1):3369.
  • Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet (London, England). 2021;397(10270):220-32.
  • Hastie CE, Lowe DJ, McAuley A, Winter AJ, Mills NL, Black C, et al. Outcomes among confirmed cases and a matched comparison group in the Long-COVID in Scotland study. Nature Communications. 2022;13(1):5663.
There are 30 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Article
Authors

Saliha Kazcı 0000-0002-8937-9939

Arzu Mirza 0000-0001-8713-3671

Meltem Çöl 0000-0001-7089-1644

Caner Baysan 0000-0002-7675-1391

Çağanay Soysal 0000-0002-4381-6099

Elif Yilmaz 0000-0001-5107-6492

Barış Örs 0000-0001-7144-3560

Gönül Tanır 0000-0002-9617-136X

Publication Date May 31, 2023
Submission Date April 3, 2023
Published in Issue Year 2023 Volume: 8 Issue: 2

Cite

Vancouver Kazcı S, Mirza A, Çöl M, Baysan C, Soysal Ç, Yilmaz E, Örs B, Tanır G. BİR EĞİTİM VE ARAŞTIRMA HASTANESİNDE COVID-19 GEÇİREN SAĞLIK ÇALIŞANLARINDA AŞILANMA DURUMU VE KLİNİK ÖZELLİKLER. ESTUDAM Public Health Journal. 2023;8(2):206-19.
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