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Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD ve FXID Hastalıklarının Araştırılması

Year 2021, Volume: 18 Issue: 1, 26 - 30, 01.04.2021

Esma Gamze Aksel Fadime Daldaban Korhan Arslan Hasan Hüseyin Keçeli Bilal Akyüz

https://doi.org/10.32707/ercivet.878012

Abstract

Bu çalışmada Türkiye’deki Holştayn melezlerinde Sığır Lökosit Bağlanma Eksikliği (BLAD) ve Faktör XI Eksikliği (FXID) kalıtsal hastalıklarına sebep olan mutant allellerin varlığının araştırılması amaçlanmıştır. Çalışmada toplam 48 baş sığır incelenmiştir. Yapılan moleküler analizlerden sonra incelenen melez sığırların birinin BLAD taşıyıcısı olduğu, FXID taşıyıcısı bireye rastlanılmadığı görülmüştür. Bu çalışma ile bu kalıtsal hastalıkların görüldüğü saf Holştayn ırkı dışında da BLAD ve FXID’ne sebep olan mutant allellerin varlığı araştırılmıştır. Böylece saf Holştayn ırkının haricinde de BLAD’a sebep olan mutant allelin varlığı ilk kez gösterilmiştir. Çalışma sonunda özellikle ıslah ve çevirme melezle-melerinde baba hat olarak kullanılacak damızlıkların, önemli kalıtsal hastalıklardan ari olduklarının kontrol edilmesi gerektiği sonucuna varılmıştır. Eğer bu konuda gerekli özen gösterilmez ise daha önce ırka özgü olduğu bilinen kalıtsal hastalıklara (BLAD, FIXID vb.) sebep olan mutant allellerin diğer sığır ırklarına da yayılabileceği sonucuna varılmıştır.

Keywords

BLAD FXID Holştayn melezi kalıtsal hastalık sığır

References

  • Ackermann MR, Kehrli ME, Morfitt DC. Ventral der-matitis and vasculitis in a calf with bovine leukocyte adhesion deficiency. J AM Vet Med 1993; 202(3): 413-5.
  • Agerholm JS. Inherited disorders in Danish cattle. Apmis Suppl 2007; 115: 1-76.
  • Akyüz B, Ertuǧrul O. Detection of bovine leukocyte adhesion deficiency (BLAD) in Turkish native and Holstein cattle. Acta Vet Hung 2006; 54(2): 173-8.
  • Akyuz B, Sariozkan S, Bayram D. Factor XI mutation in normally fertile and repeat breeding Holstein cows in the Middle Anatolian region of Turkey: A financial approach. Anim Prod Sci 2012; 52(11): 1042-5.
  • Avanus K. Altınel A. Identification of allele frequency of factor XI deficiency (FXID) in Holstein cows rea-red in thrace region of Turkey. İstanbul Üniv Vet Fak Derg 2016; 42: 190-3.
  • Blöttner S, Heins BJ, Wensch-Dorendorf M, Hansen LB, Swalve HH. A comparison between purebred Holstein and Brown Swiss × Holstein cows for milk production, somatic cell score, milking speed, and udder measurements in the first 3 lactations. J Dairy Sci 2011; 94: 5212-6.
  • Citek J, Rehout V, Hajkova J, Pavkova J. Monitoring of the genetic health of cattle in the Czech Repub-lic. Vet Med-Czech 2006; 51(6): 333-9.
  • Cole J B, Null DJ, VanRaden PM. Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility. J Dairy Sci 2016; 99(9): 7274-88.
  • Czarnik U, Grzybowski G, Kamiński S, Prusak B, Zabolewicz T. Effectiveness of a program aimed at the elimination of BLAD-carrier bulls from Polish Holstein-Friesian cattle. J Appl Genet 2007; 48(4): 375-7.
  • Ghanem ME, Nishibori M, Nakao T, Nakatani K, Akita M. Factor XI mutation in a Holstein cow with repeat breeding in Japan. J Vet Med Sci 2005; 67(7): 713-5.
  • Hacihasanoğlu Çakmak N, Yardibi H. Detection of allele and genotype frequencies of bovine leukocy-te adhesion deficiency, factor XI deficiency and complex vertebral malformation disease genes in holstein cattle. Ankara Univ Vet Fak Derg 2019; 66(3): 311-5.
  • Hemati B, Fazeli M H, Namvar Z, Ranji M. Investiga-tion of bovine leukocyte adhesion deficiency (BLAD) and complex vertebral malformation (CVM) in a population of Iranian Holstein cows. Iran J Appl Anim Sci 2015; 5(1): 69-72.
  • Kehrli ME, Schmalstieg FC, Anderson DC, Van der Maaten MJ, Hughes BJ, Ackermann MR, Wil-helmsen CL, Brown GB, Stevens MG, Whetstone CA. Molecular definition of the bovine granulocyto-pathy syndrome: Identification of deficiency of the Mac-1 (CD11b/CD18) glycoprotein. Am J Vet Res 1990; 51(11): 1826-36.
  • Korkmaz Ağaoğlu Ö, Ağaoğlu AR, Saatci M. Estima-ting allele frequencies of some hereditary diseases in Holstein cattle reared in Burdur Province, Turkey. Turk J Vet Anim Sci 2015; 39(3): 338-42.
  • Liptrap RM, Gentry PA, Ross ML, Cummings E. Preli-minary findings of altered follicular activity in Hols-tein cows with coagulation factor XI deficiency. Vet Res Commun 1995; 19(6): 463-71.
  • Marron BM, Robinson JL, Gentry PA, Beever JE. Identification of a mutation associated with factor XI deficiency in Holstein cattle. Anim Genet 2004; 35(6): 454-6.
  • Medeiros CMO, Forrel F, Oliveria ATD, Rodrigues JL. Current status of sperm cryopreservation: Why isn’t it better? Spill Sci Technol B 2002; 57: 327-44.
  • Morkūnienė K, Bižienė R, Pečiulaitienė N, Ugens-kienė R. Detection of bovine leukocyte adhesion deficiency, deficiency of uridine monophosphate synthase, and complex vertebral malformation in holstein cattle. Slov Vet Res 2019; 56(2): 75-82.
  • Mukhopadhyaya PN, Jha M, Muraleedharan P, Gup-ta RR, Rathod RN, Mehta HH, Khoda VK. Simula-tion of normal, carrier and affected controls for lar-ge-scale genotyping of cattle for factor XI defici-ency. Genet Mol Res 2006; 5(2): 323-32.
  • Nagahata H. Bovine leukocyte adhesion deficiency (BLAD): A review. J Vet Med Sci 2004; 66(12): 1475-82.
  • Nagahata H, Miura T, Tagaki K, Ohtake M, Noda H, Yasuda T, Nioka K. Prevalence and allele frequ-ency estimation of bovine leukocyte adhesion defi-ciency (BLAD) in Holstein-Friesian cattle in Japan. J Vet Med Sci 1997; 59(4): 233-8.
  • Norouzy A, Nassiry M R, Eftekhari Shahrody F, Ja-vadmanesh A, Mohammad Abadi M R, Sulimova G E. Identification of bovine leucocyte adhesion deficiency (BLAD) carriers in Holstein and Brown Swiss AI bulls in Iran. Russ J Genet 2005; 41(12): 1409-13.
  • Öner Y, Keskin A, Elmaci C. Identification of BLAD, DUMPS, citrullinamia and factor XI deficiency in Holstein cattle in Turkey. Asian J Anim Vet Adv 2010; 5: 60-5.
  • Patel RK, Singh KM, Soni KJ, Chauhan JB, Sambasi-va Rao KRS. Low incidence of bovine leukocyte adhesion deficiency (BLAD) carriers in Indian cattle and buffalo breeds. J Appl Genet 2007; 48(2): 153-5.
  • Roy A, Kotikalapudi R, Patel R K, Anantaneni R, Kat-ragadda S. New cases of bovine leukocyte adhe-sion deficiency (BLAD) carriers in Indian Holstein cattle. Inter J Vet Sci 2012; 1(2): 80-2.
  • Şahin E, Karsli T, Galiç A, Balcioǧlu MS. Identifica-tion of bovine leukocyte adhesion deficiency (BLAD) and bovine citrullinaemia (BC) alleles in Holstein cows reared in Antalya region. J Appl Anim Res 2013; 41(1): 56-60.
  • Schütz E, Scharfenstein M, Brenig B. Implication of complex vertebral malformation and bovine leu-kocyte adhesion deficiency DNA-based testing on disease frequency in the holstein population. J Dairy Sci 2008; 91(12): 4854-9.
  • Shuster DE, Kehrli ME, Ackermann MR, Gilbert RO. Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Hols-tein cattle. Proc Nat Acad Sci USA 1992; 89(19): 9225-9.
  • Sun DX, Fan XH, Xie Y, Chu Q, Sun Y, Zhang Y, Zhang SL, Gong WJ, Chen SH, Li YH, Shi WH, Zhang Y. Short communication: Distribution of re-cessive genetic defect carriers in Chinese Holstein. J Dairy Sci 2011; 94(11): 5695-8.
  • Thomsen B, Horn P, Panitz F, Bendixen E, Petersen AH, Holm LE, Nielsen VH, Agerholm JS, Arnbjerg J, Bendixen C. A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation. Genome Res 2006; 16(1): 97-105.
  • Turner L. Crossbreeding in Dairy Herds. http://www.dairyinfo.biz/images/Content/M5/132 Crossb-reeding.pdf; Erişim tarihi: 16.10.2020.
  • Yaylak E, Akbaş Y, Özsoy A. Siyah Alaca ile bazı süt sığır ırkları arasında yapılan melezlemeler ve melez ineklerin performansları. Ziraat Fakültesi Dergisi 2015; 10(1): 97-106.
  • Zhang Y, Fan X, Sun D, Wang Y, Yu Y, Xie Y, Zhang S, Zhang Y. A novel method for rapid and reliable detection of complex vertebral malformation and bovine leukocyte adhesion deficiency in Holstein cattle. J Anim Sci Biotechnol 2012; 3: 24.

Investigation of FXID and BLAD Diseases in Holstein Crossbreed Cattles Reared in Turkey

Year 2021, Volume: 18 Issue: 1, 26 - 30, 01.04.2021

Esma Gamze Aksel Fadime Daldaban Korhan Arslan Hasan Hüseyin Keçeli Bilal Akyüz

https://doi.org/10.32707/ercivet.878012

Abstract

This study aimed to investigate the presence of mutant alleles of Bovine Leukocyte Binding Deficiency (BLAD) and Factor XI Deficiency (FXID) hereditary diseases in Holstein crossbreeds reared in Turkey. Total of 48 cat-tle were examined in the study. After molecular analysis, it was observed that one of the crossbreed cattle examined was a BLAD carrier and no FXID carrier was found. With this study, the presence of mutant alleles that cause BLAD and FXID, except for the purebred Holstein in which these hereditary diseases are seen, was investigated. So, It was determined for the first time that the presence of mutant allele was also seen in crossbreed Holstein. At the end of the study, it was concluded that breeds to be used as sire lines in breeding and crossbreeding should be checked which they had free from important hereditary diseases. It is concluded that mutant alleles that cause hereditary diseases (BLAD, FIXID, etc.), which were previously known to be breed-specific, can spread to other cattle breeds if the neces-sary care is not taken.

Keywords

BLAD FXID Holstein crossbreed hereditary disease cattle

References

  • Ackermann MR, Kehrli ME, Morfitt DC. Ventral der-matitis and vasculitis in a calf with bovine leukocyte adhesion deficiency. J AM Vet Med 1993; 202(3): 413-5.
  • Agerholm JS. Inherited disorders in Danish cattle. Apmis Suppl 2007; 115: 1-76.
  • Akyüz B, Ertuǧrul O. Detection of bovine leukocyte adhesion deficiency (BLAD) in Turkish native and Holstein cattle. Acta Vet Hung 2006; 54(2): 173-8.
  • Akyuz B, Sariozkan S, Bayram D. Factor XI mutation in normally fertile and repeat breeding Holstein cows in the Middle Anatolian region of Turkey: A financial approach. Anim Prod Sci 2012; 52(11): 1042-5.
  • Avanus K. Altınel A. Identification of allele frequency of factor XI deficiency (FXID) in Holstein cows rea-red in thrace region of Turkey. İstanbul Üniv Vet Fak Derg 2016; 42: 190-3.
  • Blöttner S, Heins BJ, Wensch-Dorendorf M, Hansen LB, Swalve HH. A comparison between purebred Holstein and Brown Swiss × Holstein cows for milk production, somatic cell score, milking speed, and udder measurements in the first 3 lactations. J Dairy Sci 2011; 94: 5212-6.
  • Citek J, Rehout V, Hajkova J, Pavkova J. Monitoring of the genetic health of cattle in the Czech Repub-lic. Vet Med-Czech 2006; 51(6): 333-9.
  • Cole J B, Null DJ, VanRaden PM. Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility. J Dairy Sci 2016; 99(9): 7274-88.
  • Czarnik U, Grzybowski G, Kamiński S, Prusak B, Zabolewicz T. Effectiveness of a program aimed at the elimination of BLAD-carrier bulls from Polish Holstein-Friesian cattle. J Appl Genet 2007; 48(4): 375-7.
  • Ghanem ME, Nishibori M, Nakao T, Nakatani K, Akita M. Factor XI mutation in a Holstein cow with repeat breeding in Japan. J Vet Med Sci 2005; 67(7): 713-5.
  • Hacihasanoğlu Çakmak N, Yardibi H. Detection of allele and genotype frequencies of bovine leukocy-te adhesion deficiency, factor XI deficiency and complex vertebral malformation disease genes in holstein cattle. Ankara Univ Vet Fak Derg 2019; 66(3): 311-5.
  • Hemati B, Fazeli M H, Namvar Z, Ranji M. Investiga-tion of bovine leukocyte adhesion deficiency (BLAD) and complex vertebral malformation (CVM) in a population of Iranian Holstein cows. Iran J Appl Anim Sci 2015; 5(1): 69-72.
  • Kehrli ME, Schmalstieg FC, Anderson DC, Van der Maaten MJ, Hughes BJ, Ackermann MR, Wil-helmsen CL, Brown GB, Stevens MG, Whetstone CA. Molecular definition of the bovine granulocyto-pathy syndrome: Identification of deficiency of the Mac-1 (CD11b/CD18) glycoprotein. Am J Vet Res 1990; 51(11): 1826-36.
  • Korkmaz Ağaoğlu Ö, Ağaoğlu AR, Saatci M. Estima-ting allele frequencies of some hereditary diseases in Holstein cattle reared in Burdur Province, Turkey. Turk J Vet Anim Sci 2015; 39(3): 338-42.
  • Liptrap RM, Gentry PA, Ross ML, Cummings E. Preli-minary findings of altered follicular activity in Hols-tein cows with coagulation factor XI deficiency. Vet Res Commun 1995; 19(6): 463-71.
  • Marron BM, Robinson JL, Gentry PA, Beever JE. Identification of a mutation associated with factor XI deficiency in Holstein cattle. Anim Genet 2004; 35(6): 454-6.
  • Medeiros CMO, Forrel F, Oliveria ATD, Rodrigues JL. Current status of sperm cryopreservation: Why isn’t it better? Spill Sci Technol B 2002; 57: 327-44.
  • Morkūnienė K, Bižienė R, Pečiulaitienė N, Ugens-kienė R. Detection of bovine leukocyte adhesion deficiency, deficiency of uridine monophosphate synthase, and complex vertebral malformation in holstein cattle. Slov Vet Res 2019; 56(2): 75-82.
  • Mukhopadhyaya PN, Jha M, Muraleedharan P, Gup-ta RR, Rathod RN, Mehta HH, Khoda VK. Simula-tion of normal, carrier and affected controls for lar-ge-scale genotyping of cattle for factor XI defici-ency. Genet Mol Res 2006; 5(2): 323-32.
  • Nagahata H. Bovine leukocyte adhesion deficiency (BLAD): A review. J Vet Med Sci 2004; 66(12): 1475-82.
  • Nagahata H, Miura T, Tagaki K, Ohtake M, Noda H, Yasuda T, Nioka K. Prevalence and allele frequ-ency estimation of bovine leukocyte adhesion defi-ciency (BLAD) in Holstein-Friesian cattle in Japan. J Vet Med Sci 1997; 59(4): 233-8.
  • Norouzy A, Nassiry M R, Eftekhari Shahrody F, Ja-vadmanesh A, Mohammad Abadi M R, Sulimova G E. Identification of bovine leucocyte adhesion deficiency (BLAD) carriers in Holstein and Brown Swiss AI bulls in Iran. Russ J Genet 2005; 41(12): 1409-13.
  • Öner Y, Keskin A, Elmaci C. Identification of BLAD, DUMPS, citrullinamia and factor XI deficiency in Holstein cattle in Turkey. Asian J Anim Vet Adv 2010; 5: 60-5.
  • Patel RK, Singh KM, Soni KJ, Chauhan JB, Sambasi-va Rao KRS. Low incidence of bovine leukocyte adhesion deficiency (BLAD) carriers in Indian cattle and buffalo breeds. J Appl Genet 2007; 48(2): 153-5.
  • Roy A, Kotikalapudi R, Patel R K, Anantaneni R, Kat-ragadda S. New cases of bovine leukocyte adhe-sion deficiency (BLAD) carriers in Indian Holstein cattle. Inter J Vet Sci 2012; 1(2): 80-2.
  • Şahin E, Karsli T, Galiç A, Balcioǧlu MS. Identifica-tion of bovine leukocyte adhesion deficiency (BLAD) and bovine citrullinaemia (BC) alleles in Holstein cows reared in Antalya region. J Appl Anim Res 2013; 41(1): 56-60.
  • Schütz E, Scharfenstein M, Brenig B. Implication of complex vertebral malformation and bovine leu-kocyte adhesion deficiency DNA-based testing on disease frequency in the holstein population. J Dairy Sci 2008; 91(12): 4854-9.
  • Shuster DE, Kehrli ME, Ackermann MR, Gilbert RO. Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Hols-tein cattle. Proc Nat Acad Sci USA 1992; 89(19): 9225-9.
  • Sun DX, Fan XH, Xie Y, Chu Q, Sun Y, Zhang Y, Zhang SL, Gong WJ, Chen SH, Li YH, Shi WH, Zhang Y. Short communication: Distribution of re-cessive genetic defect carriers in Chinese Holstein. J Dairy Sci 2011; 94(11): 5695-8.
  • Thomsen B, Horn P, Panitz F, Bendixen E, Petersen AH, Holm LE, Nielsen VH, Agerholm JS, Arnbjerg J, Bendixen C. A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation. Genome Res 2006; 16(1): 97-105.
  • Turner L. Crossbreeding in Dairy Herds. http://www.dairyinfo.biz/images/Content/M5/132 Crossb-reeding.pdf; Erişim tarihi: 16.10.2020.
  • Yaylak E, Akbaş Y, Özsoy A. Siyah Alaca ile bazı süt sığır ırkları arasında yapılan melezlemeler ve melez ineklerin performansları. Ziraat Fakültesi Dergisi 2015; 10(1): 97-106.
  • Zhang Y, Fan X, Sun D, Wang Y, Yu Y, Xie Y, Zhang S, Zhang Y. A novel method for rapid and reliable detection of complex vertebral malformation and bovine leukocyte adhesion deficiency in Holstein cattle. J Anim Sci Biotechnol 2012; 3: 24.
There are 33 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Esma Gamze Aksel This is me 0000-0002-0040-8933

Fadime Daldaban This is me

Korhan Arslan

Hasan Hüseyin Keçeli

Bilal Akyüz

Publication Date April 1, 2021
Submission Date October 26, 2020
Acceptance Date November 17, 2020
Published in Issue Year 2021 Volume: 18 Issue: 1

Cite

APA Aksel, E. G., Daldaban, F., Arslan, K., Keçeli, H. H., et al. (2021). Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD ve FXID Hastalıklarının Araştırılması. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 18(1), 26-30. https://doi.org/10.32707/ercivet.878012
AMA Aksel EG, Daldaban F, Arslan K, Keçeli HH, Akyüz B. Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD ve FXID Hastalıklarının Araştırılması. Erciyes Üniv Vet Fak Derg. April 2021;18(1):26-30. doi:10.32707/ercivet.878012
Chicago Aksel, Esma Gamze, Fadime Daldaban, Korhan Arslan, Hasan Hüseyin Keçeli, and Bilal Akyüz. “Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD Ve FXID Hastalıklarının Araştırılması”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 18, no. 1 (April 2021): 26-30. https://doi.org/10.32707/ercivet.878012.
EndNote Aksel EG, Daldaban F, Arslan K, Keçeli HH, Akyüz B (April 1, 2021) Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD ve FXID Hastalıklarının Araştırılması. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 18 1 26–30.
IEEE E. G. Aksel, F. Daldaban, K. Arslan, H. H. Keçeli, and B. Akyüz, “Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD ve FXID Hastalıklarının Araştırılması”, Erciyes Üniv Vet Fak Derg, vol. 18, no. 1, pp. 26–30, 2021, doi: 10.32707/ercivet.878012.
ISNAD Aksel, Esma Gamze et al. “Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD Ve FXID Hastalıklarının Araştırılması”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi 18/1 (April 2021), 26-30. https://doi.org/10.32707/ercivet.878012.
JAMA Aksel EG, Daldaban F, Arslan K, Keçeli HH, Akyüz B. Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD ve FXID Hastalıklarının Araştırılması. Erciyes Üniv Vet Fak Derg. 2021;18:26–30.
MLA Aksel, Esma Gamze et al. “Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD Ve FXID Hastalıklarının Araştırılması”. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, vol. 18, no. 1, 2021, pp. 26-30, doi:10.32707/ercivet.878012.
Vancouver Aksel EG, Daldaban F, Arslan K, Keçeli HH, Akyüz B. Türkiye’de Yetiştirilen Holştayn Melezi Sığırlarda BLAD ve FXID Hastalıklarının Araştırılması. Erciyes Üniv Vet Fak Derg. 2021;18(1):26-30.
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