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Evaluation of olfactory functions in patients with laryngopharyngeal reflux

Year 2017, Volume: 7 Issue: 3, 144 - 148, 28.11.2017
https://doi.org/10.32448/entupdates.404522

Abstract

Objective: To evaluate olfactory functions in patients with laryngopharyngeal reflux.


Methods: The
study consisted of control and reflux groups. Each group consisted of 50
patients. Reflux group received the diagnosis of reflux based on reflux
symptom index, and reflux symptom scores. The olfactory test of
Connecticut Chemosensory Clinical Research Center (CCCRC) was conducted
on these 2 groups, and the results were compared.


Results: No
statistically significant difference was found between the demographic
characteristics such as gender and smoking rates while there was
statistically significant difference between the groups in terms of age
variable. The covariance analysis was used to eliminate the effect of
age variable. The mean scores calculated after covariance analysis were
compared. It is known that the higher score of CCCRC test is 7 points.
Accordingly, CCCRC scores of the control and reflux groups were 5.84±
0.13, and 5.20±0.11, respectively. This difference between two groups
was statistically significant (p<0.001).


Conclusion: Laryngopharyngeal reflux disease has a negative effect on olfactory functions without total loss in olfactory functions.

References

  • 1. Ford CN. Evaluation and management of laryngopharyngeal reflux. JAMA 2005;294:1534–40. 2. Katz PO. State of the art: extraesophageal manifestations of gas- troesophageal reflux disease. Rev Gastroenterol Disord 2005;5: 126–34. 3. Landis BN, Konnerth CG, Hummel T. A study on the frequency of olfactory dysfunction. Laryngoscope 2004;114:1764–9. 4. Brämerson A, Johansson L, Ek L, Nordin S, Bende M. Prevalence of olfactory dysfunction: the Skövde population-based study. Laryngoscope 2004;114:733–7. 5. Klinkenberg-Knol EC. Otolaryngologic manifestations of gastro- oesophageal reflux disease. Scand J Gastroenterol Suppl 1998;33 (225):24–8. 6. Habesoglu TE, Habesoglu M, Sürmeli M, et al. Histological changes of rat soft palate with exposure to experimental laryn- gopharyngeal reflux. Auris Nasus Larynx 2010;37:730–6. 7. Abdel-aziz MM, El-Fattah AM, Abdalla AF. Clinical evaluation of pepsin for laryngopharyngeal reflux in children with otitis media with effusion. Int J Pediatr Otorhinolaryngol 2013;77:1765–70. 8. Megale SR, Scanavini AB, Andrade EC, Fernandes MI, Anselmo- Lima WT. Gastroesophageal reflux disease: its importance in ear, nose, and throat practice. Int J Pediatr Otorhinolaryngol 2006;70: 81–8. 9. Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroe- sophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Arch Otolaryngol Head Neck Surg 2000;126: 831–6. 10. Toros SZ, Toros AB, Ozel L, et al. Investigation of gastric pepsino- gen in middle ear fluid of children with glue ear. Acta Otolaryngol 2010;130:1220–4. 11. Tasker A, Dettmar PW, Panetti M, Koufman JA, P Birchall J, Pearson JP. Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope 2002;112:1930–4. 12. Hellgren J, Olin AC, Torén K. Increased risk of rhinitis symptoms in subjects with gastroesophageal reflux. Acta Otolaryngol 2014; 134:615–9. 13. Weaver EM. Association between gastroesophageal reflux and sinusitis, otitis media, and laryngeal malignancy: a systematic review of the evidence. Am J Med 2003;115 Suppl 3A:81S–89S. 14. Barbero GJ. Gastroesophageal reflux and upper airway disease. Otolaryngol Clin North Am 1996;29:27–38. 15. Halstead LA. Role of gastroesophageal reflux in pediatric upper airway disorders. Otolaryngol Head Neck Surg 1999;120:208–14. 16. Contencin P, Narcy P. Nasopharyngeal pH monitoring in infants and children with chronic rhinopharyngitis. Int J Pediatr Otorhino- laryngol 1991;22:249–56. 17. Veyseller B, Ozucer B, Karaaltin AB, Yildirim Y, Degirmenci N, Aksoy F, Ozturan O. Connecticut (CCCRC) Olfactory test: nor- mative values in 426 healthy volunteers. Indian J Otolaryngol Head Neck Surg 2014;66:31–4. 18. Günbey E, Gören ‹, Ünal R, Y›lmaz M. An evaluation of olfacto- ry function in adults with gastro-esophageal reflux disease. Acta Otolaryngol 2016;136:214–8. 19. Emre Dinc M, Dalgic A, Avincsal MO, Ulusoy S, Celik A, Develioglu ON. An assessment of olfactory function in patients with laryngopharyngeal reflux disease. Acta Otolaryngol 2017;137: 71–7.
Year 2017, Volume: 7 Issue: 3, 144 - 148, 28.11.2017
https://doi.org/10.32448/entupdates.404522

Abstract

References

  • 1. Ford CN. Evaluation and management of laryngopharyngeal reflux. JAMA 2005;294:1534–40. 2. Katz PO. State of the art: extraesophageal manifestations of gas- troesophageal reflux disease. Rev Gastroenterol Disord 2005;5: 126–34. 3. Landis BN, Konnerth CG, Hummel T. A study on the frequency of olfactory dysfunction. Laryngoscope 2004;114:1764–9. 4. Brämerson A, Johansson L, Ek L, Nordin S, Bende M. Prevalence of olfactory dysfunction: the Skövde population-based study. Laryngoscope 2004;114:733–7. 5. Klinkenberg-Knol EC. Otolaryngologic manifestations of gastro- oesophageal reflux disease. Scand J Gastroenterol Suppl 1998;33 (225):24–8. 6. Habesoglu TE, Habesoglu M, Sürmeli M, et al. Histological changes of rat soft palate with exposure to experimental laryn- gopharyngeal reflux. Auris Nasus Larynx 2010;37:730–6. 7. Abdel-aziz MM, El-Fattah AM, Abdalla AF. Clinical evaluation of pepsin for laryngopharyngeal reflux in children with otitis media with effusion. Int J Pediatr Otorhinolaryngol 2013;77:1765–70. 8. Megale SR, Scanavini AB, Andrade EC, Fernandes MI, Anselmo- Lima WT. Gastroesophageal reflux disease: its importance in ear, nose, and throat practice. Int J Pediatr Otorhinolaryngol 2006;70: 81–8. 9. Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroe- sophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Arch Otolaryngol Head Neck Surg 2000;126: 831–6. 10. Toros SZ, Toros AB, Ozel L, et al. Investigation of gastric pepsino- gen in middle ear fluid of children with glue ear. Acta Otolaryngol 2010;130:1220–4. 11. Tasker A, Dettmar PW, Panetti M, Koufman JA, P Birchall J, Pearson JP. Is gastric reflux a cause of otitis media with effusion in children? Laryngoscope 2002;112:1930–4. 12. Hellgren J, Olin AC, Torén K. Increased risk of rhinitis symptoms in subjects with gastroesophageal reflux. Acta Otolaryngol 2014; 134:615–9. 13. Weaver EM. Association between gastroesophageal reflux and sinusitis, otitis media, and laryngeal malignancy: a systematic review of the evidence. Am J Med 2003;115 Suppl 3A:81S–89S. 14. Barbero GJ. Gastroesophageal reflux and upper airway disease. Otolaryngol Clin North Am 1996;29:27–38. 15. Halstead LA. Role of gastroesophageal reflux in pediatric upper airway disorders. Otolaryngol Head Neck Surg 1999;120:208–14. 16. Contencin P, Narcy P. Nasopharyngeal pH monitoring in infants and children with chronic rhinopharyngitis. Int J Pediatr Otorhino- laryngol 1991;22:249–56. 17. Veyseller B, Ozucer B, Karaaltin AB, Yildirim Y, Degirmenci N, Aksoy F, Ozturan O. Connecticut (CCCRC) Olfactory test: nor- mative values in 426 healthy volunteers. Indian J Otolaryngol Head Neck Surg 2014;66:31–4. 18. Günbey E, Gören ‹, Ünal R, Y›lmaz M. An evaluation of olfacto- ry function in adults with gastro-esophageal reflux disease. Acta Otolaryngol 2016;136:214–8. 19. Emre Dinc M, Dalgic A, Avincsal MO, Ulusoy S, Celik A, Develioglu ON. An assessment of olfactory function in patients with laryngopharyngeal reflux disease. Acta Otolaryngol 2017;137: 71–7.
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Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Yusuf Çağdaş Kumbul

Hüseyin Işık This is me

Aykut Erdem Dinç This is me

Duygu Erdem This is me

Sultan Şevik Eliçora This is me

Publication Date November 28, 2017
Submission Date October 2, 2017
Published in Issue Year 2017 Volume: 7 Issue: 3

Cite

APA Kumbul, Y. Ç., Işık, H., Dinç, A. E., Erdem, D., et al. (2017). Evaluation of olfactory functions in patients with laryngopharyngeal reflux. ENT Updates, 7(3), 144-148. https://doi.org/10.32448/entupdates.404522
AMA Kumbul YÇ, Işık H, Dinç AE, Erdem D, Şevik Eliçora S. Evaluation of olfactory functions in patients with laryngopharyngeal reflux. ENT Updates. November 2017;7(3):144-148. doi:10.32448/entupdates.404522
Chicago Kumbul, Yusuf Çağdaş, Hüseyin Işık, Aykut Erdem Dinç, Duygu Erdem, and Sultan Şevik Eliçora. “Evaluation of Olfactory Functions in Patients With Laryngopharyngeal Reflux”. ENT Updates 7, no. 3 (November 2017): 144-48. https://doi.org/10.32448/entupdates.404522.
EndNote Kumbul YÇ, Işık H, Dinç AE, Erdem D, Şevik Eliçora S (November 1, 2017) Evaluation of olfactory functions in patients with laryngopharyngeal reflux. ENT Updates 7 3 144–148.
IEEE Y. Ç. Kumbul, H. Işık, A. E. Dinç, D. Erdem, and S. Şevik Eliçora, “Evaluation of olfactory functions in patients with laryngopharyngeal reflux”, ENT Updates, vol. 7, no. 3, pp. 144–148, 2017, doi: 10.32448/entupdates.404522.
ISNAD Kumbul, Yusuf Çağdaş et al. “Evaluation of Olfactory Functions in Patients With Laryngopharyngeal Reflux”. ENT Updates 7/3 (November 2017), 144-148. https://doi.org/10.32448/entupdates.404522.
JAMA Kumbul YÇ, Işık H, Dinç AE, Erdem D, Şevik Eliçora S. Evaluation of olfactory functions in patients with laryngopharyngeal reflux. ENT Updates. 2017;7:144–148.
MLA Kumbul, Yusuf Çağdaş et al. “Evaluation of Olfactory Functions in Patients With Laryngopharyngeal Reflux”. ENT Updates, vol. 7, no. 3, 2017, pp. 144-8, doi:10.32448/entupdates.404522.
Vancouver Kumbul YÇ, Işık H, Dinç AE, Erdem D, Şevik Eliçora S. Evaluation of olfactory functions in patients with laryngopharyngeal reflux. ENT Updates. 2017;7(3):144-8.