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The predictive value of three-dimensional Doppler ultrasonography in determining implantation in patients underwent in vitro fertilization

Year 2015, Volume: 42 Issue: 4, 472 - 479, 08.01.2016

Yusuf Çakmak Mehmet Şentürk Mehmet Budak

Abstract

Objective: The aim of this study is to evaluate the relationship between endometrial and sub-endometrial blood flow and implantation rate in patients whose undergone in vitro fertilization.

Methods: A prospective study was conducted. Long protocol and antagonist regimens were administered to the patients. Endometrial and sub-endometrial blood flow was evaluated by using 3 dimensional Doppler ultrasonography on the day of oocyt retrieval measurement. For comparison pregnant and non-pregnant women in terms of endometrial and sub-endometrial blood flow, t test was used. The p value was considered statistically meaningful as <0.05.

Results: Endometrial and sub-endometrial blood flow was not different between pregnant and non-pregnant women in both groups (p>0.05). In long protocol group, the number of embryo was greater in pregnant women than non-pregnant women (p=0.012). The number of transferred embryo increased pregnancy rate almost 3.5 fold (p=0.002).

Conclusion: The endometrial and subendometrial blood flow is not reliable factor in prediction pregnancy or implantation.

Key words: Doppler ultrasonography, in vitro fertilization, pregnant women

Keywords

Doppler ultrasonografi gebe kadınlar invitro fertilizasyon

References

  • Ng EH, Chan CC, Tang OS, Ho PC. Comparison of 2-dimensional,
  • -dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles. J Ultrasound Med. 2007;26:931-939.
  • Bahar L, Kahraman S, Akkus A, Baykal T. Fine structure and
  • immune histochemical evaluation of endometrium in fertile and infertile women with implantation failure. Dicle Medical Journal 2012;39:269-295.
  • Gannon BJ, Carati CJ, Verco CJ. Endometrial perfusion across the normal human menstrual cycle assessed by laser Doppler fluxmetry. Hum Reprod. 1997;12:132-139.
  • Raine-Fenning NJ, Campbell BK, Clewes JS, Kendall NR, Johnson IR. The reliability of virtual organ computer-aided analysis (VOCAL) for the semi quantification of ovarian, endometrial and subendometrial perfusion. Ultrasound Obstet Gynecol 2003;22:633-639.
  • Chien LW, Au HK, Chen PL, et al. Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer. Fertil Steril 2002;78:245-251.
  • Hsieh YY, Chang FC, Tsai HD. Doppler evaluation of the uterine and spiral arteries from different sampling sites and phases of the menstrual cycle during controlled ovarian hyper-stimulation.
  • Ultrasound Obstet. Gynecol 200;16:192-196.
  • Raine-Fenning N. The role of three-dimensional ultrasound in assisted reproduction treatment. Ultrasound Obstet Gynecol 2004;23:317-322.
  • Ng EH, Chan CC, Tang OS, et al. The role of endometrial and sub-endometrial blood flows measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during IVF treatment. Hum Reprod 2006;21:164-170.
  • Guerriero S, Ajossa S, Lai MP, et al. Clinical applications of colour Doppler energy imaging in the female reproductive tract and pregnancy. Hum Reprod Update 1999;5:515-529.
  • Zaidi J, Campbell S, Pittrof FR and Tan SL. Endometrial
  • thickness morphology, vascular penetration and velocimetry in predicting implantation in an IVF program. Ultrasound Obstet Gynecol 1995;6:191-198.
  • Ng EHY, Chan CCW, Tang OS, et al. Endometrial and subendometrial blood flow measured during early luteal phase
  • by three dimensional Power Doppler ultrasound in excessive ovarian responders. Hum Reprod 2004;19:924-931.
  • Merce LT, Barco MJ, Bau S, Troyano J. Are endometrial parameters by three-dimensional ultrasound and power Doppler
  • angiography related to in vitro fertilization/embryo transfer outcome? Fertil Steril 2008;89:111.
  • Achache H, Revel A. Endometrial receptivity markers, the
  • journey to successful embryo implantation. Hum Reprod Update 2006;12:731.
  • Kim A, Jung H, Choi WJ, et al. Detection of endometrial and sub-endometrial vasculature on the day of embryo transfer and prediction of pregnancy during fresh in vitro fertilization cycles. Taiwan J Obstet Gynecol 2014;53:360-365.
  • Battaglia C, Artini PG, Giulini S, et al. Colour Doppler changes and thromboxane production after ovarian stimulation with gonadotrophin- releasing hormone agonist. Hum Reprod 1997;12:2477-2482.
  • Kupesic S, Bekavac I, Bjelos D, Kurjak A. Assessment of endometrial receptivity by transvaginal color Doppler and three-dimensional power Doppler ultrasonography in patients undergoing in vitro fertilization procedures. J Ultrasound Med 2001;20:125-134.
  • Merce LT, Barco MJ, Bau S, Troyano J. Are endometrial parameters by three-dimensional ultrasound and power Doppler
  • angiography related to in vitro fertilization/embryo transfer outcome? Fertil Steril 2008;89:111-117.
  • Wu HM, Chiang CH, Huang HY, et al. Detection of the subendometrial vascularization flow index by three-dimensional
  • ultrasound may be useful for predicting the pregnancy rate for patients undergoing in vitro fertilization-embryo transfer. Fertil Steril 2003;79:507-511.
  • Dechaud H, Bessueille E, Bousquet PJ, et al. Optimal timing of ultrasonographic and Doppler evaluation of uterine receptivity to implantation.Reprod Biomed Online.2008;16:368-375.
  • Fraser IS, Mc Carron G, Hutton B, Macey D. Endometrial blood flow measured by xenon 133 clearance in women with normal menstrual cycles and dysfunctional uterine bleeding. Am J Obstet Gynecol 1987;156:158-166.
  • Nandi A, Martins WP, Jayaprakasan K, et al. Assessment of endometrial and subendometrial blood flow in women undergoing frozen embryo transfer cycles. Reprod Biomed Online. 2014;28:343-351.
  • Spandorfer SD, Arrendondo-Soberon F, Loret de Mola JR, Feinberg RF. Reliability of intraobserver and interobserver sonographic endometrial stripe thickness measurements. Fertil Steril 1998;70:152-154.
  • Raine-Fenning NJ, Clewes JS, Kendall NR, et al. The inter observer reliability and validity of volume calculation from three-dimensional ultrasound data sets in the in vitro setting. Ultrasound Obstet Gynecol 2003;21:283-291

Year 2015, Volume: 42 Issue: 4, 472 - 479, 08.01.2016

Yusuf Çakmak Mehmet Şentürk Mehmet Budak

Abstract

References

  • Ng EH, Chan CC, Tang OS, Ho PC. Comparison of 2-dimensional,
  • -dimensional, and vascular ultrasonographic parameters for endometrial receptivity between 2 consecutive stimulated in vitro fertilization cycles. J Ultrasound Med. 2007;26:931-939.
  • Bahar L, Kahraman S, Akkus A, Baykal T. Fine structure and
  • immune histochemical evaluation of endometrium in fertile and infertile women with implantation failure. Dicle Medical Journal 2012;39:269-295.
  • Gannon BJ, Carati CJ, Verco CJ. Endometrial perfusion across the normal human menstrual cycle assessed by laser Doppler fluxmetry. Hum Reprod. 1997;12:132-139.
  • Raine-Fenning NJ, Campbell BK, Clewes JS, Kendall NR, Johnson IR. The reliability of virtual organ computer-aided analysis (VOCAL) for the semi quantification of ovarian, endometrial and subendometrial perfusion. Ultrasound Obstet Gynecol 2003;22:633-639.
  • Chien LW, Au HK, Chen PL, et al. Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer. Fertil Steril 2002;78:245-251.
  • Hsieh YY, Chang FC, Tsai HD. Doppler evaluation of the uterine and spiral arteries from different sampling sites and phases of the menstrual cycle during controlled ovarian hyper-stimulation.
  • Ultrasound Obstet. Gynecol 200;16:192-196.
  • Raine-Fenning N. The role of three-dimensional ultrasound in assisted reproduction treatment. Ultrasound Obstet Gynecol 2004;23:317-322.
  • Ng EH, Chan CC, Tang OS, et al. The role of endometrial and sub-endometrial blood flows measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during IVF treatment. Hum Reprod 2006;21:164-170.
  • Guerriero S, Ajossa S, Lai MP, et al. Clinical applications of colour Doppler energy imaging in the female reproductive tract and pregnancy. Hum Reprod Update 1999;5:515-529.
  • Zaidi J, Campbell S, Pittrof FR and Tan SL. Endometrial
  • thickness morphology, vascular penetration and velocimetry in predicting implantation in an IVF program. Ultrasound Obstet Gynecol 1995;6:191-198.
  • Ng EHY, Chan CCW, Tang OS, et al. Endometrial and subendometrial blood flow measured during early luteal phase
  • by three dimensional Power Doppler ultrasound in excessive ovarian responders. Hum Reprod 2004;19:924-931.
  • Merce LT, Barco MJ, Bau S, Troyano J. Are endometrial parameters by three-dimensional ultrasound and power Doppler
  • angiography related to in vitro fertilization/embryo transfer outcome? Fertil Steril 2008;89:111.
  • Achache H, Revel A. Endometrial receptivity markers, the
  • journey to successful embryo implantation. Hum Reprod Update 2006;12:731.
  • Kim A, Jung H, Choi WJ, et al. Detection of endometrial and sub-endometrial vasculature on the day of embryo transfer and prediction of pregnancy during fresh in vitro fertilization cycles. Taiwan J Obstet Gynecol 2014;53:360-365.
  • Battaglia C, Artini PG, Giulini S, et al. Colour Doppler changes and thromboxane production after ovarian stimulation with gonadotrophin- releasing hormone agonist. Hum Reprod 1997;12:2477-2482.
  • Kupesic S, Bekavac I, Bjelos D, Kurjak A. Assessment of endometrial receptivity by transvaginal color Doppler and three-dimensional power Doppler ultrasonography in patients undergoing in vitro fertilization procedures. J Ultrasound Med 2001;20:125-134.
  • Merce LT, Barco MJ, Bau S, Troyano J. Are endometrial parameters by three-dimensional ultrasound and power Doppler
  • angiography related to in vitro fertilization/embryo transfer outcome? Fertil Steril 2008;89:111-117.
  • Wu HM, Chiang CH, Huang HY, et al. Detection of the subendometrial vascularization flow index by three-dimensional
  • ultrasound may be useful for predicting the pregnancy rate for patients undergoing in vitro fertilization-embryo transfer. Fertil Steril 2003;79:507-511.
  • Dechaud H, Bessueille E, Bousquet PJ, et al. Optimal timing of ultrasonographic and Doppler evaluation of uterine receptivity to implantation.Reprod Biomed Online.2008;16:368-375.
  • Fraser IS, Mc Carron G, Hutton B, Macey D. Endometrial blood flow measured by xenon 133 clearance in women with normal menstrual cycles and dysfunctional uterine bleeding. Am J Obstet Gynecol 1987;156:158-166.
  • Nandi A, Martins WP, Jayaprakasan K, et al. Assessment of endometrial and subendometrial blood flow in women undergoing frozen embryo transfer cycles. Reprod Biomed Online. 2014;28:343-351.
  • Spandorfer SD, Arrendondo-Soberon F, Loret de Mola JR, Feinberg RF. Reliability of intraobserver and interobserver sonographic endometrial stripe thickness measurements. Fertil Steril 1998;70:152-154.
  • Raine-Fenning NJ, Clewes JS, Kendall NR, et al. The inter observer reliability and validity of volume calculation from three-dimensional ultrasound data sets in the in vitro setting. Ultrasound Obstet Gynecol 2003;21:283-291
There are 32 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Yusuf Çakmak This is me

Mehmet Şentürk

Mehmet Budak This is me

Publication Date January 8, 2016
Submission Date January 8, 2016
Published in Issue Year 2015 Volume: 42 Issue: 4

Cite

APA Çakmak, Y., Şentürk, M., & Budak, M. (2016). The predictive value of three-dimensional Doppler ultrasonography in determining implantation in patients underwent in vitro fertilization. Dicle Tıp Dergisi, 42(4), 472-479. https://doi.org/10.5798/diclemedj.0921.2015.04.0611
AMA Çakmak Y, Şentürk M, Budak M. The predictive value of three-dimensional Doppler ultrasonography in determining implantation in patients underwent in vitro fertilization. diclemedj. January 2016;42(4):472-479. doi:10.5798/diclemedj.0921.2015.04.0611
Chicago Çakmak, Yusuf, Mehmet Şentürk, and Mehmet Budak. “The Predictive Value of Three-Dimensional Doppler Ultrasonography in Determining Implantation in Patients Underwent in Vitro Fertilization”. Dicle Tıp Dergisi 42, no. 4 (January 2016): 472-79. https://doi.org/10.5798/diclemedj.0921.2015.04.0611.
EndNote Çakmak Y, Şentürk M, Budak M (January 1, 2016) The predictive value of three-dimensional Doppler ultrasonography in determining implantation in patients underwent in vitro fertilization. Dicle Tıp Dergisi 42 4 472–479.
IEEE Y. Çakmak, M. Şentürk, and M. Budak, “The predictive value of three-dimensional Doppler ultrasonography in determining implantation in patients underwent in vitro fertilization”, diclemedj, vol. 42, no. 4, pp. 472–479, 2016, doi: 10.5798/diclemedj.0921.2015.04.0611.
ISNAD Çakmak, Yusuf et al. “The Predictive Value of Three-Dimensional Doppler Ultrasonography in Determining Implantation in Patients Underwent in Vitro Fertilization”. Dicle Tıp Dergisi 42/4 (January 2016), 472-479. https://doi.org/10.5798/diclemedj.0921.2015.04.0611.
JAMA Çakmak Y, Şentürk M, Budak M. The predictive value of three-dimensional Doppler ultrasonography in determining implantation in patients underwent in vitro fertilization. diclemedj. 2016;42:472–479.
MLA Çakmak, Yusuf et al. “The Predictive Value of Three-Dimensional Doppler Ultrasonography in Determining Implantation in Patients Underwent in Vitro Fertilization”. Dicle Tıp Dergisi, vol. 42, no. 4, 2016, pp. 472-9, doi:10.5798/diclemedj.0921.2015.04.0611.
Vancouver Çakmak Y, Şentürk M, Budak M. The predictive value of three-dimensional Doppler ultrasonography in determining implantation in patients underwent in vitro fertilization. diclemedj. 2016;42(4):472-9.