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Year 2023, Volume: 13 Issue: 3, 664 - 678, 11.09.2023
https://doi.org/10.33808/clinexphealthsci.1125345

Abstract

References

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Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade

Year 2023, Volume: 13 Issue: 3, 664 - 678, 11.09.2023
https://doi.org/10.33808/clinexphealthsci.1125345

Abstract

Objective: Plants have been used to treat ailments since the dawn of humanity. The use of medicinal plants for various purposes such as preventing diseases, treating diseases and supporting medical treatment is increasing day by day. On the other hand, medicinal plants are important sources of raw materials for the pharmaceutical industry. It has been demonstrated that Peganum harmala L. and the phytochemicals it contains have a wide variety of pharmacological activities. P. harmala and its active ingredients can be an important resource for the pharmaceutical industry. In this review, the phytochemistry, pharmacological effects, clinical studies, and toxicity of P. harmala are discussed under the current information.
Methods: Studies on P. harmala were searched using Pubmed, Scopus, Science Direct databases, and Google Scholar search engine. As a result of the searches, 96 articles were included in the study.
Results: The main group of secondary metabolites responsible for the biological activities of P. harmala is alkaloids. The plant and its isolated secondary plant compounds have been shown to have many pharmacological actions, counting antiamnestic, anticancer, antidepressant, antiinflammatory, cardiovascular, gastroprotective, hepatoprotective, nephroprotective, and vasodilator activities. Studies evaluating the plant's clinical effects have been carried out in recent years. However, it has been recorded in the literature that the use of P. harmala causes poisoning with symptoms such as neurosensory symptoms, visual hallucination, bradycardia, hypotension, agitation, tremor, ataxia, and vomiting. Conclusion: Considering the pharmacological effects, the number of studies on the efficacy and safety of P. harmala and its secondary metabolites should be increased.

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There are 96 citations in total.

Details

Primary Language English
Subjects Pharmacognosy
Journal Section Review
Authors

İçim Gökkaya 0000-0003-0803-2886

Gülin Renda 0000-0001-6323-0338

Tuğba Subaş 0000-0002-0956-6567

Ufuk Özgen 0000-0001-9839-6717

Publication Date September 11, 2023
Submission Date June 2, 2022
Published in Issue Year 2023 Volume: 13 Issue: 3

Cite

APA Gökkaya, İ., Renda, G., Subaş, T., Özgen, U. (2023). Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade. Clinical and Experimental Health Sciences, 13(3), 664-678. https://doi.org/10.33808/clinexphealthsci.1125345
AMA Gökkaya İ, Renda G, Subaş T, Özgen U. Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade. Clinical and Experimental Health Sciences. September 2023;13(3):664-678. doi:10.33808/clinexphealthsci.1125345
Chicago Gökkaya, İçim, Gülin Renda, Tuğba Subaş, and Ufuk Özgen. “Phytochemical, Pharmacological, and Toxicological Studies on Peganum Harmala L.: An Overview of the Last Decade”. Clinical and Experimental Health Sciences 13, no. 3 (September 2023): 664-78. https://doi.org/10.33808/clinexphealthsci.1125345.
EndNote Gökkaya İ, Renda G, Subaş T, Özgen U (September 1, 2023) Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade. Clinical and Experimental Health Sciences 13 3 664–678.
IEEE İ. Gökkaya, G. Renda, T. Subaş, and U. Özgen, “Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade”, Clinical and Experimental Health Sciences, vol. 13, no. 3, pp. 664–678, 2023, doi: 10.33808/clinexphealthsci.1125345.
ISNAD Gökkaya, İçim et al. “Phytochemical, Pharmacological, and Toxicological Studies on Peganum Harmala L.: An Overview of the Last Decade”. Clinical and Experimental Health Sciences 13/3 (September 2023), 664-678. https://doi.org/10.33808/clinexphealthsci.1125345.
JAMA Gökkaya İ, Renda G, Subaş T, Özgen U. Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade. Clinical and Experimental Health Sciences. 2023;13:664–678.
MLA Gökkaya, İçim et al. “Phytochemical, Pharmacological, and Toxicological Studies on Peganum Harmala L.: An Overview of the Last Decade”. Clinical and Experimental Health Sciences, vol. 13, no. 3, 2023, pp. 664-78, doi:10.33808/clinexphealthsci.1125345.
Vancouver Gökkaya İ, Renda G, Subaş T, Özgen U. Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade. Clinical and Experimental Health Sciences. 2023;13(3):664-78.

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