Research Article
Year 2018,
Volume: 5 Issue: 3, 76 - 79, 28.09.2018
Abstract
Giriş:
Akciğer kanserinde, bronkoalveoler karsinom ve miks tip adenokarsinom
terminolojisi terk edilmiştir. İnvazif adenokarsinomlar lepidik, asiner,
papiller ve solid olarak sınıflandırılmaktadır. Bu sınıflandırma ile
adenokarsinom histopatolojik alt tip tanımlamasına standartizasyon getirilmesi
hedeflenmiştir. Bu çalışmanın amacı akciğer adenokarsinom alt tiplerinde uzun
süreli sağkalımı değerlendirmektir.
Gereç ve yöntem: Küçük hücreli dışı
akciğer kanseri nedeni ile opere edilen ve patolojik sonuçları adenokarsinom
olan toplam 128 hasta çalışmaya dahil edildi. Hastaların demografik
özellikleri, rezeksiyon tipi, tümör boyutu, histolojik alt tipleri ve sağ
kalımları değerlendirildi.
Bulgular : Çalışmamızda
109 (% 85.1) erkek ve 19 (% 14.9) kadın olmak üzere toplam 128 hasta vardı.
Histopatolojik olarak, asiner paternde 48 olgu (% 37.5), lepidik paternde 32 olgu (% 25), solid paternte 34 olgu (%
26.5) ve 14 olgu (% 10,9) in-situ paternde idi. Histopatolojik tip ve ortalama
sağkalım süresi arasında istatistiksel olarak anlamlı bir fark yoktu.
Sonuç: Histolojik
alt tip hayatta kalma süresi açısından etkili değildir ancak gelecekte spesifik
hedefe yönelik tedaviler ile oldukça önemli hale gelecektir.
Keywords
References
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- 5. Van Schil PE, Asamura H, Rusch VW, et al. Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification. Eur Respir J 2012;39:478-86.
- 6. Mok T, Yang JJ, Lam KC. Treating patients with EGFRsensitizing mutations: first line or second line--is there a difference? J Clin Oncol 2013;31:1081-8.
- 7. Shaw AT, Engelman JA. ALK in lung cancer: past, present, and future. J Clin Oncol 2013;31:1105-11.
- 8. Yoshizawa A, Motoi N, Riely GJ, et al. Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod Pathol 2011; 24:653-64.
- 9. T. Yokose, K. Suzuki, K. Nagai, Y. Nishiwaki, S. Sasaki, A. Ochiai, Favorable and unfavorable morphological prognostic factors in peripheral adenocarcinomaof the lung 3 cm or less in diameter, Lung Cancer 2000; 29:179–88.
- 10. Okada M, Nishio W, Sakamoto T, et al. Effect of tumor size on prognosis in patients with non-small cell lung cancer: the role of segmentectomy as a type of lesser resection. J Thorac Cardiovasc Surg 2005;129:87-93.
- 11. A. Warth, T. Muley, M. Meister, A. Stenzinger, M. Thomas, P. Schirmacher, P.A.Schnabel, et al.The novel histologicInternational Association for the Study of Lung Cancer/American ThoracicSociety/European Respiratory Society classification system of lungadenocarcinoma is a stage-independent predictor of survival, J. Clin. Oncol. 2012;30:1438–1446
Year 2018,
Volume: 5 Issue: 3, 76 - 79, 28.09.2018
Abstract
References
- 1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics,2002. CA Cancer J Clin. 2005;55:74–108.
- 2. R.S. Herbst, J.V. Heymach, S.M. Lippman. Lung cancer. N. Engl. J. Med. 2008;359:1367–80.
- 3. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of lung adenocarcinoma. J Thorac Oncol 2011;6:244–85.
- 4. Motoi N, Szoke J, Riely GJ, Seshan VE, Kris MG, Rusch VW, et al. Lung adenocarcinoma:modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis. Am J Surg Pathol 2008;32:810–27.
- 5. Van Schil PE, Asamura H, Rusch VW, et al. Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification. Eur Respir J 2012;39:478-86.
- 6. Mok T, Yang JJ, Lam KC. Treating patients with EGFRsensitizing mutations: first line or second line--is there a difference? J Clin Oncol 2013;31:1081-8.
- 7. Shaw AT, Engelman JA. ALK in lung cancer: past, present, and future. J Clin Oncol 2013;31:1105-11.
- 8. Yoshizawa A, Motoi N, Riely GJ, et al. Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod Pathol 2011; 24:653-64.
- 9. T. Yokose, K. Suzuki, K. Nagai, Y. Nishiwaki, S. Sasaki, A. Ochiai, Favorable and unfavorable morphological prognostic factors in peripheral adenocarcinomaof the lung 3 cm or less in diameter, Lung Cancer 2000; 29:179–88.
- 10. Okada M, Nishio W, Sakamoto T, et al. Effect of tumor size on prognosis in patients with non-small cell lung cancer: the role of segmentectomy as a type of lesser resection. J Thorac Cardiovasc Surg 2005;129:87-93.
- 11. A. Warth, T. Muley, M. Meister, A. Stenzinger, M. Thomas, P. Schirmacher, P.A.Schnabel, et al.The novel histologicInternational Association for the Study of Lung Cancer/American ThoracicSociety/European Respiratory Society classification system of lungadenocarcinoma is a stage-independent predictor of survival, J. Clin. Oncol. 2012;30:1438–1446
There are 11 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Araştırma Makalesi |
| Authors | |
| Publication Date | September 28, 2018 |
| Published in Issue | Year 2018 Volume: 5 Issue: 3 |
