Research Article
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Brucellosis: A Retrospective Evaluation of 170 Cases

Year 2019, Volume: 2 Issue: 3, 60 - 64, 01.09.2019

Abstract

Brucellosis is an important disease with devastating outcomes in developing countries and may cause complications in
many organ systems. The clinical and laboratory characteristics of 170 cases of brucellosis followed at the Afyon
Kocatepe University Faculty of Medicine Infectious Diseases Clinic and Afyonkarahisar State Hospital of Medicine
Infectious Diseases Clinic in Turkey, were retrospectively evaluated. In our study, total of 170 patients (female, n=74;
43.5%, and male, n=96; 56.5%) with a mean age of 44.12 ± 15.52 years were included. The patients were living in rural
areas (n=134; 78.8%) or in the city center (n=36; 21.2%), while 112 (65.9%) patients were raising livestock and 84
patients (49.4%) were consumers of unpasteurized raw milk and dairy products. The most frequent complaints
detected in patients with brucellosis include joint pain, fever, weakness, back pain and gastrointestinal symptoms.
Fever, arthritis and scrotal swelling were observed more frequently than the others. The standard tube agglutination
titer was > 1/160 in 150 (88.2%) patients. Blood cultures have positive results in 68 (59.6%) patients. Complications
were detected in 45 patients (26.4%). Osteoarticular system involvement was the most common complication in 33
(19.4%) patients. Other complications were epididymo-orchitis in 9 (5.3%) and depression in 3 (1.8%) patients (Table
2). Sacroileitis was the most frequent osteoarticular involvement which was detected in 13 (7.6%) patients. Other
osteoarticular involvements were peripheral monoarthritis in 11 (6.5%), and spondylodiscitis in 9 (5.3%) patients.
Increased C-reactive protein (CRP) and high serum transaminase levels were significantly higher in the complication
groups. The most frequent drug treatment was rifampicin and doxycyline among different treatment regimens.
Brucellosis should be considered in the differential diagnosis of patients who present with fever and osteoarticular
symptoms. Laboratory results can help the clinician to identify the complications of this disease, especially
osteoarticular complications.

References

  • Al Dahouk S, Nöckler K. 2011. Implications of laboratory diagnosis on brucellosis therapy. Expert Rev. Anti Infect. Ther, 9: 833–845.
  • Ariza J, Bosilkovski M, Cascio A. 2007. Perspectives for the Treatment of Brucellosis in the 21st Century: The Ioannina Recommendations. PloS Med, 4: 1872-1878.
  • Ataman-Hatipoğlu C, Kınklı S, Tulek N, Tekin-Koruk S, Arslan S, Tuncer-Ertem G. 2005. Bir eğitim hastanesinin infeksiyon hastalıkları ve klinik mikrobiyoloji kliniginde izlenen 202 bruselloz olgusunun epidemiyolojik verilerinin irdelenmesi. Klimik Derg, 18: 94–98.
  • Aygen B, Doğanay M, Sümerkan B, Yıldız O, Kayabas U. 2002. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Mal Infect, 32: 485–493.
  • Barua A, Kumar A, D. Tavaselvam et al. 2016. Isolation & characterization of brucella melitensis isolated from patients suspected for human brucellosis in India, Te Indian Journal of Medical Research, 143: 652–658.
  • Bulut C, Yetkin MA, Yılmaz G, Erdinc FŞ, Hatipoğlu CA, Kınıklı S. 2011. Assessment of the findings on the existence of complications in brucellosis. Turk J Med Sci, 41: 275–282.
  • Buzgan T, Karahocagil MK, Irmak H. 2010. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis, 14: 469-478.
  • Calık Ş, Gokengin AD. 2011. Human brucellosis in Turkey: a review of the literature between 1990 and 2009. Turk J Med Sci, 41: 549–555.
  • Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J. 2012. Clinical manifestations of human brucellosis: a systematic review and meta-analysis, PLOS Neglected Tropical Diseases, 12: e1929.
  • Demiroğlu YZ, Turunc T, Alışkan H, Colakoğlu, Arslan H,. 2007. Brucellosis: retrospective evaluation of the clinical, laboratory and epidemiological features in 151 cases. Mikrobiyol Bül, 41: 517–527.
  • Demirtürk N, Demirdal T, Erben N. 2008. Brucellosis: a retrospective evaluation of 99 cases and review of brucellosis treatment. Trop Doct, 38: 59-62.
  • Doğanay M, Meşe EA. 2008. Bruselloz. In: Willke Topçu A, Söyletir G, Doğanay M, eds. Enfeksiyon Hastalıkları ve Mikrobiyolojisi. 3. baskı. İstanbul: Nobel Tıp Kitabevleri, p. 897-908.
  • Erbaydar T, Serpen A, Kurt AÖ. 2012. Hasuder, “Bulaşıcı Hastalıklar”. In: Türkiye Sağlık Raporu. Franco MP, Mulder M, Gilman RH, Smits HL. 2007. Human brucellosis. Lancet Infect Dis, 7: 775–786.
  • Gonen I, Sozen H, Kaya O, Unal O, Guloğlu G, Akcam FZ. 2014. Brucellosis: evaluation of 201 cases in an endemic area of mediterranean basin. Acta Medica Mediterranea, 30: 12-126.
  • Gul HC, Erdem H. 2015. Brucella Species. In: Mandell GL, Bennet JE, Dolin R, eds. Mandell, Douglas, and Bennett’s. Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Churchill Livingstone Elsevier.
  • Gür A, Geyik MF, Dikici B, Nas K, Cevik R, Sarac J. 2003. Complications of brucellosis in different age groups: a study of 283 cases in Southeastern Anatolia of Turkey. Yonsei Med J, 44: 33–44.
  • Hasanjani Roushan MR, Mohrez M, Smailnejad Gangi SM, Solemani Amiri MJ, Hajiahmadi M. 2004. Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, Northern Iran. Epidemiol Infect, 132: 1109–1114.
  • Kayaaslan B, Akıncı E, Baştuğ A, Eren SS, Öngürü P, But A, Yetkin MA, Bodur H. 2013. Analysis of 161 adult patients with brucellosis. Turk J Med Science, 43: 187-193.
  • Kursun E, Turunc T, Demiroglu Y, Arslan H. 2013. Evaluation of Four Hundred and Forty Seven Brucellosis Cases. Intern Med, 52: 745-750.
  • Kurtaran B, Candevir A, İnal AS, Kömür S, Akyıldız Ö, Saltoğlu N, Aksu HSZ, Taşova Y. 2012. Clinical appearance of brucellosis in adults: fourteen years of experience. Turk J Med, 42: 497-505.
  • Mert A, Ozaras R, Tabak F, Bilir M, Yilmaz M, Kurt C, Ongoren S, Tanriverdi M, Ozturk R. 2003. The sensitivity and specificity of Brucella agglutination tests. Diagn Microbiol Infect Dis, 46: 241–243.
  • Navarro JM, Mendoza J, Leiva J, Rodriguez-Contreras R, de la Rosa M. 1990. C-reactive protein as a prognostic indicator in acute brucellosis. Diagn Microbiol Infect Dis, 13: 269-270.
  • Naz H, Aykin N, Cevik F, Bal C. 2009. Brucellosis in central Anatolia: evaluation of complications and relapse. Trop Doct, 39: 107–109.
  • Uluğ M, Uluğ NC. 2010. Brusellozlu 78 olgunun değerlendirilmesi. Klimik Derg, 23: 89-94.
  • Vancelik S, Guraksin A, Ayyildiz A. 2008. Seroprevalence of human brucellosis in rural endemic areas in eastern Turkey. Trop Doct, 38: 42–43.
  • Young EJ. 2010. Brucella Species. In: Mandell GL, Bennet JE, Dolin R, eds. Mandell, Douglas, and Bennett’s. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia: Churchill Livingstone Elsevier, 2921-2925.
  • Yuce A, Alp-Cavuş S. 2006. Brucellosis in Turkey: a review. Klimik Derg, 19: 87–97.
  • Yumuk Z, Callaghan DO. 2012. Brucellosis in Turkey - an overview. International Journal of Infectious Diseases, 16: 228–235.
  • Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K. 2018. A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China. Biomed Res Int, https://doi.org/10.1155/2018/5712920.
Year 2019, Volume: 2 Issue: 3, 60 - 64, 01.09.2019

Abstract

References

  • Al Dahouk S, Nöckler K. 2011. Implications of laboratory diagnosis on brucellosis therapy. Expert Rev. Anti Infect. Ther, 9: 833–845.
  • Ariza J, Bosilkovski M, Cascio A. 2007. Perspectives for the Treatment of Brucellosis in the 21st Century: The Ioannina Recommendations. PloS Med, 4: 1872-1878.
  • Ataman-Hatipoğlu C, Kınklı S, Tulek N, Tekin-Koruk S, Arslan S, Tuncer-Ertem G. 2005. Bir eğitim hastanesinin infeksiyon hastalıkları ve klinik mikrobiyoloji kliniginde izlenen 202 bruselloz olgusunun epidemiyolojik verilerinin irdelenmesi. Klimik Derg, 18: 94–98.
  • Aygen B, Doğanay M, Sümerkan B, Yıldız O, Kayabas U. 2002. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Med Mal Infect, 32: 485–493.
  • Barua A, Kumar A, D. Tavaselvam et al. 2016. Isolation & characterization of brucella melitensis isolated from patients suspected for human brucellosis in India, Te Indian Journal of Medical Research, 143: 652–658.
  • Bulut C, Yetkin MA, Yılmaz G, Erdinc FŞ, Hatipoğlu CA, Kınıklı S. 2011. Assessment of the findings on the existence of complications in brucellosis. Turk J Med Sci, 41: 275–282.
  • Buzgan T, Karahocagil MK, Irmak H. 2010. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis, 14: 469-478.
  • Calık Ş, Gokengin AD. 2011. Human brucellosis in Turkey: a review of the literature between 1990 and 2009. Turk J Med Sci, 41: 549–555.
  • Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J. 2012. Clinical manifestations of human brucellosis: a systematic review and meta-analysis, PLOS Neglected Tropical Diseases, 12: e1929.
  • Demiroğlu YZ, Turunc T, Alışkan H, Colakoğlu, Arslan H,. 2007. Brucellosis: retrospective evaluation of the clinical, laboratory and epidemiological features in 151 cases. Mikrobiyol Bül, 41: 517–527.
  • Demirtürk N, Demirdal T, Erben N. 2008. Brucellosis: a retrospective evaluation of 99 cases and review of brucellosis treatment. Trop Doct, 38: 59-62.
  • Doğanay M, Meşe EA. 2008. Bruselloz. In: Willke Topçu A, Söyletir G, Doğanay M, eds. Enfeksiyon Hastalıkları ve Mikrobiyolojisi. 3. baskı. İstanbul: Nobel Tıp Kitabevleri, p. 897-908.
  • Erbaydar T, Serpen A, Kurt AÖ. 2012. Hasuder, “Bulaşıcı Hastalıklar”. In: Türkiye Sağlık Raporu. Franco MP, Mulder M, Gilman RH, Smits HL. 2007. Human brucellosis. Lancet Infect Dis, 7: 775–786.
  • Gonen I, Sozen H, Kaya O, Unal O, Guloğlu G, Akcam FZ. 2014. Brucellosis: evaluation of 201 cases in an endemic area of mediterranean basin. Acta Medica Mediterranea, 30: 12-126.
  • Gul HC, Erdem H. 2015. Brucella Species. In: Mandell GL, Bennet JE, Dolin R, eds. Mandell, Douglas, and Bennett’s. Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Churchill Livingstone Elsevier.
  • Gür A, Geyik MF, Dikici B, Nas K, Cevik R, Sarac J. 2003. Complications of brucellosis in different age groups: a study of 283 cases in Southeastern Anatolia of Turkey. Yonsei Med J, 44: 33–44.
  • Hasanjani Roushan MR, Mohrez M, Smailnejad Gangi SM, Solemani Amiri MJ, Hajiahmadi M. 2004. Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, Northern Iran. Epidemiol Infect, 132: 1109–1114.
  • Kayaaslan B, Akıncı E, Baştuğ A, Eren SS, Öngürü P, But A, Yetkin MA, Bodur H. 2013. Analysis of 161 adult patients with brucellosis. Turk J Med Science, 43: 187-193.
  • Kursun E, Turunc T, Demiroglu Y, Arslan H. 2013. Evaluation of Four Hundred and Forty Seven Brucellosis Cases. Intern Med, 52: 745-750.
  • Kurtaran B, Candevir A, İnal AS, Kömür S, Akyıldız Ö, Saltoğlu N, Aksu HSZ, Taşova Y. 2012. Clinical appearance of brucellosis in adults: fourteen years of experience. Turk J Med, 42: 497-505.
  • Mert A, Ozaras R, Tabak F, Bilir M, Yilmaz M, Kurt C, Ongoren S, Tanriverdi M, Ozturk R. 2003. The sensitivity and specificity of Brucella agglutination tests. Diagn Microbiol Infect Dis, 46: 241–243.
  • Navarro JM, Mendoza J, Leiva J, Rodriguez-Contreras R, de la Rosa M. 1990. C-reactive protein as a prognostic indicator in acute brucellosis. Diagn Microbiol Infect Dis, 13: 269-270.
  • Naz H, Aykin N, Cevik F, Bal C. 2009. Brucellosis in central Anatolia: evaluation of complications and relapse. Trop Doct, 39: 107–109.
  • Uluğ M, Uluğ NC. 2010. Brusellozlu 78 olgunun değerlendirilmesi. Klimik Derg, 23: 89-94.
  • Vancelik S, Guraksin A, Ayyildiz A. 2008. Seroprevalence of human brucellosis in rural endemic areas in eastern Turkey. Trop Doct, 38: 42–43.
  • Young EJ. 2010. Brucella Species. In: Mandell GL, Bennet JE, Dolin R, eds. Mandell, Douglas, and Bennett’s. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia: Churchill Livingstone Elsevier, 2921-2925.
  • Yuce A, Alp-Cavuş S. 2006. Brucellosis in Turkey: a review. Klimik Derg, 19: 87–97.
  • Yumuk Z, Callaghan DO. 2012. Brucellosis in Turkey - an overview. International Journal of Infectious Diseases, 16: 228–235.
  • Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K. 2018. A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China. Biomed Res Int, https://doi.org/10.1155/2018/5712920.
There are 29 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Research Article
Authors

Havva Tunay

Nese Demirturk 0000-0002-6186-2494

Petek Sarlak Konya 0000-0001-5055-1220

Serap Pamukcuoglu This is me 0000-0001-5090-2510

Publication Date September 1, 2019
Submission Date April 1, 2019
Acceptance Date May 26, 2019
Published in Issue Year 2019 Volume: 2 Issue: 3

Cite

APA Tunay, H., Demirturk, N., Sarlak Konya, P., Pamukcuoglu, S. (2019). Brucellosis: A Retrospective Evaluation of 170 Cases. Black Sea Journal of Health Science, 2(3), 60-64.
AMA Tunay H, Demirturk N, Sarlak Konya P, Pamukcuoglu S. Brucellosis: A Retrospective Evaluation of 170 Cases. BSJ Health Sci. September 2019;2(3):60-64.
Chicago Tunay, Havva, Nese Demirturk, Petek Sarlak Konya, and Serap Pamukcuoglu. “Brucellosis: A Retrospective Evaluation of 170 Cases”. Black Sea Journal of Health Science 2, no. 3 (September 2019): 60-64.
EndNote Tunay H, Demirturk N, Sarlak Konya P, Pamukcuoglu S (September 1, 2019) Brucellosis: A Retrospective Evaluation of 170 Cases. Black Sea Journal of Health Science 2 3 60–64.
IEEE H. Tunay, N. Demirturk, P. Sarlak Konya, and S. Pamukcuoglu, “Brucellosis: A Retrospective Evaluation of 170 Cases”, BSJ Health Sci., vol. 2, no. 3, pp. 60–64, 2019.
ISNAD Tunay, Havva et al. “Brucellosis: A Retrospective Evaluation of 170 Cases”. Black Sea Journal of Health Science 2/3 (September 2019), 60-64.
JAMA Tunay H, Demirturk N, Sarlak Konya P, Pamukcuoglu S. Brucellosis: A Retrospective Evaluation of 170 Cases. BSJ Health Sci. 2019;2:60–64.
MLA Tunay, Havva et al. “Brucellosis: A Retrospective Evaluation of 170 Cases”. Black Sea Journal of Health Science, vol. 2, no. 3, 2019, pp. 60-64.
Vancouver Tunay H, Demirturk N, Sarlak Konya P, Pamukcuoglu S. Brucellosis: A Retrospective Evaluation of 170 Cases. BSJ Health Sci. 2019;2(3):60-4.