Research Article
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Pedicularis comosa L. var. acmodonta Boiss. türünün antioksidan ve antikandidal etkilerinin belirlenmesi

Year 2023, Volume: 16 Issue: 3, 224 - 228, 15.12.2023

Nagehan Saltan Zeynep Gülcan Gökalp İşcan Yavuz Bülent Köse

https://doi.org/10.46309/biodicon.2023.1270516

Abstract

Özet
Bu çalışmanın amacı, Pedicularis comosa var. acmodonta (Orobanchaceae) türünün antioksidan ve antikandidal aktivitesini değerlendirmektir. Türkiye'de yetişen P. comosa var. acmodonta ekstreleri üzerinde bir spektrofotometrik test kullanılarak, bitki ekstrelerinin antioksidan aktivitesi, 1,1-difenilpiril hidrazil (DPPH·) içeren bir metanol solüsyonundaki mor rengin açılması ölçülerek değerlendirilmiştir. Ayrıca CLSI M27-A2 yöntemi kullanılarak yapılan antikandidal etki testlerinin sonuçları da bu çalışmada yer almaktadır. P. comosa'nın %70 etanol ekstresi en yüksek antioksidan aktiviteyi (0.143 mg/mL) göstermiştir. Beş Candida türü üzerinde yapılan antikandidal aktivite testi bulgularına göre P. comosa'nın %70 etanol ekstresinin C. utilis'i 31.25 µg/mL (MIC) dozunda inhibe ettiği belirlenmiştir.

Keywords

antikandidal antioksidan Pedicularis Orobanchaceae.

References

  • [1] https://www.worldfloraonline.org/ date of access: 09.10.2023.
  • [2] Satıl, F. , Tümen, G. & Selvi, S. (2017). Balıkesir’de yayılış gösteren parazit bitkilerin etnobotanik özellikleri. Biological Diversity and Conservation, 10 (3), 7-11. Retrieved from https://dergipark.org.tr/en/pub/biodicon/issue/55729/762124
  • [3] O’Neill, A.R., Rana, S.K. (2016). An ethnobotanical analysis of parasitic plants (Parijibi) in the Nepal Himalaya. Journal of Ethnobiology and Ethnomedicine,12(14), 1-15.
  • [4] Shao, M.H., Dai, W., Yuan, S.W., Lu, Y., Chen, D.F., Wang, Q. (2018). Iridoids from Pedicularis verticillata and their anti-complementary activity. Chemistry and Biodiversity, 15, e1800033. https://doi.org/10.1002/cbdv.201800033.
  • [5] Jiang, T.F., Ou, Q.Y., Shi, Y.P. (2003). Separation and determination of phenylpropanoid glycosides from Pedicularis species by capillary electrophoresis. Journal of Chromatography A, 986(1), 163-167. https://doi.org/10.1016/S0021-9673(02)01918-0.
  • [6] Zhang, Z.X., xie, W.D., Jia, Z.J. (2008). Glycosids from two Pedicularis species. Biochemical Systematics and Ecology, 36(5-6), 467-472.
  • [7] Akdemir, Z., Çalis, I., Junior, P. (1991). Iridoids and phenylpropanoid glycosides from Pedicularis nordmanniana. Planta Medica, 57(6), 584-585. DOI: 10.1055/s-2006-960215.
  • [8] Fujii, M., Miyaichi, Y., Tomimori, T. (1995). Flavonoid, phenylethanoid and iridoid constituents of the whole plant of Pedicularis longiflora var. tubiformis. Planta Medica, 61(6), 584. DOI: 10.1055/s-2006-959387.
  • [9] Su, B.N., Ma, L.P., Jia, Z.J. (1998). Iridoid and phenylpropanoid glycosides from Pedicularis artselaeri. Planta Medica, 64(8), 720-723. DOI: 10.1055/s-2006-957565.
  • [10] Li, M., He, X., Tao, R., Cao, X. (2014). Phytochemistry and pharmacologyof the genus Pedicularis used in traditional Chinese medicine. The American Journal of Chinise Medicine, 42, 1071-95. https://doi.org/10.1142/S0192415X14500670.
  • [11] Şen, B., Gürdal, B., Taşkın, T., Hacıoğlu, M., Bozkurt Güzel, Ç., Tufan, S., Mat, A. (2017). Pedicularis condensata Türüne ait Anatomi ve Aktivite Çalışmaları. Marmara Pharmaceutical Journal, 21(3), 485-492.
  • [12] Khodaiea, L., Delazara, A., Lotfipour, F., Nazemiyehc, Nazemiyeh, H. (2012). Antioxidant and antimicrobial activity of Pedicularis sibthorpii Boiss. and Pedicularis wilhelmsiana Fisch ex. Advanced Pharmaceutical Bulletin, 2(1), 89-92. https://doi.org/10.5681/apb.2012.012.
  • [13] Kumarasamy, Y., Byres, M., Cox, P.J., Jaspars, M., Nahar, L., Sarker, S.D. (2007). Screening seeds of some Scottish plants for free radical scavenging activity. Phytotherapy Resarch, 21 (7), 615-621. https://doi.org/10.1002/ptr.2129.
  • [14] Zheng, R.L., Wang, P.F., Li, J., Liu, Z.M., Jia, Z.J. (1993). Inhibition of the autoxidation of linoleic acid by phenylpropanoid glycosides from Pedicularis in micelles. Chemistry and Physics of Lipids, 65(2), 151-154. https://doi.org/10.1016/0009-3084(93)90048-8.
  • [15] Scalbert, A., Johnson, I.T., Saltmarsh, M. (2005). Polyphenols: antioxidants and beyond. American Journal of Clinical Nutrition, 81(suppl), 215S-217S. https://doi.org/10.1093/ajcn/81.1.215S.
  • [16] Hosoya, T., Yun, Y.S., Kunugi, A. (2008). Antioxidant phenylpropanoid glycosides from the leaves of Wasabia japonica. Phytochemistry, 69, 827-832. https://doi.org/10.1016/j.phytochem.2007.08.021.
  • [17] Ahmad, I., Ahmad, N., Wang, F. (2009). Antioxidant phenylpropanoid glycosides from Buddleja davidii. Journal of Enzyme Inhibition and Medicinal Chemistry, 24(4), 993-997. https://doi.org/10.1080/14756360802565072.
  • [18] Biao, C.H., Hua, T.N., Sheng, P.C. (2009). Progress in research on Pedicularis plants. China Journal of Chinese Materia Medica, 34(19), 2536-2546.
  • [19] Zhu, M., Tan, N., Zhu, H., Zeng, G., He, W., Yu, B., Chen, X. (2010). Anti-sports anaemia effects of verbascoside and martynoside in mice. International Journal of Sports Medicine, 31(8), 537- 541. DOI: 10.1055/s-0030-1254115.
  • [20] Moreno-Escobar, J.A., Bazaldúa, S., Villarreal, M.L., Bonilla-Barbosa, J.R., Mendoza, S., Rodríguez-López, V. (2011). Cytotoxic and antioxidant activities of selected Lamiales species from Mexico. Pharmaceutical Biology, 49(12), 1243–1248. https://doi.org/10.3109/13880209.2011.589454.
  • [21] Turker, A.U., Yildirim, A.B., Taş, I., Ozkan, E., Turker, H. (2021). Evaluation of some traditional medicinal plants: phytochemical profile, antibacterial and antioxidant potential. Romanian Biotechnological Letters, 26(2), 2499-2510. DOI: 10.25083/rbl/26.2/2499.2510 https://doi.org/10.25083/rbl/26.2/2499.2510.
  • [22] Yatoo, M.I., Dimri, U., Gopalakrishan, A., Saminathan, M., Dhama, K., Mathesh, K., Saxena, A., Gopinath, D., Husain, S. Antidiabetic and oxidative stress ameliorative potential of ethanolic extract of Pedicularis longiflora Rudolph. International Journal of Pharmacology, 12(3), 177-187, 2016. https://doi.org/10.3923/ijp.2016.177.187.
  • [23] Lee, Y.M., Bae, J.H., Jung, H.Y., Kim, J.H., Sik, D. (2011). Antioxidant activity in water and methanol extracts from Korean edible wild plant. Journal of the Korean Society of Food Science and Nutrition, 40(1), 29-36.
  • [24] Lan, Y., Chi, X., Zhou, G., Zhao, X. (2018). Antioxidants from Pedicularis longiflora var. tubiformis (Klotzsch) P. C. Tsoong. Record of Natural Products, 12(4), 332-339. http://doi.org/10.25135/rnp.35.17.08.142.
  • [25] Dulger, B., Ugurlu, E. (2005). Evaluation of antimicrobial activity of some endemic scrophulariaceae members from Turkey. Pharmaceutical Biology, 43(3), 275–279. https://doi.org/10.1080/13880200590928870.

Antioxidant and anticandidal effects of Pedicularis comosa L. var. acmodonta Boiss.

Year 2023, Volume: 16 Issue: 3, 224 - 228, 15.12.2023

Nagehan Saltan Zeynep Gülcan Gökalp İşcan Yavuz Bülent Köse

https://doi.org/10.46309/biodicon.2023.1270516

Abstract

Abstract
The aim of this study is to measure the antioxidant and anticandidal efficiency of Pedicularis comosa var. acmodonta (Orobanchaceae). Using a spectrophotometric test on extracts from P.comosa var. acmodonta grown in Turkey, the antioxidant efficiency of the plant extracts was estimated by measuring the violet coloration in a methanol solution containing 1,1-diphenylpyryl hydrazil (DPPH·). In addition, the results of the anticandidal effect tests using the CLSI M27-A2 method are also included in this study. The 70% ethanol extract of P. comosa showed the highest antioxidant activity (0.143 mg/mL). According to the anticandidal activity test findings on five Candida species, it was determined that 70% ethanol extract of P. comosa inhibited C. utilis at a dose of 31.25 µg/mL (MIC).

Keywords

anticandidal antioxidant Pedicularis Orobanchaceae.

References

  • [1] https://www.worldfloraonline.org/ date of access: 09.10.2023.
  • [2] Satıl, F. , Tümen, G. & Selvi, S. (2017). Balıkesir’de yayılış gösteren parazit bitkilerin etnobotanik özellikleri. Biological Diversity and Conservation, 10 (3), 7-11. Retrieved from https://dergipark.org.tr/en/pub/biodicon/issue/55729/762124
  • [3] O’Neill, A.R., Rana, S.K. (2016). An ethnobotanical analysis of parasitic plants (Parijibi) in the Nepal Himalaya. Journal of Ethnobiology and Ethnomedicine,12(14), 1-15.
  • [4] Shao, M.H., Dai, W., Yuan, S.W., Lu, Y., Chen, D.F., Wang, Q. (2018). Iridoids from Pedicularis verticillata and their anti-complementary activity. Chemistry and Biodiversity, 15, e1800033. https://doi.org/10.1002/cbdv.201800033.
  • [5] Jiang, T.F., Ou, Q.Y., Shi, Y.P. (2003). Separation and determination of phenylpropanoid glycosides from Pedicularis species by capillary electrophoresis. Journal of Chromatography A, 986(1), 163-167. https://doi.org/10.1016/S0021-9673(02)01918-0.
  • [6] Zhang, Z.X., xie, W.D., Jia, Z.J. (2008). Glycosids from two Pedicularis species. Biochemical Systematics and Ecology, 36(5-6), 467-472.
  • [7] Akdemir, Z., Çalis, I., Junior, P. (1991). Iridoids and phenylpropanoid glycosides from Pedicularis nordmanniana. Planta Medica, 57(6), 584-585. DOI: 10.1055/s-2006-960215.
  • [8] Fujii, M., Miyaichi, Y., Tomimori, T. (1995). Flavonoid, phenylethanoid and iridoid constituents of the whole plant of Pedicularis longiflora var. tubiformis. Planta Medica, 61(6), 584. DOI: 10.1055/s-2006-959387.
  • [9] Su, B.N., Ma, L.P., Jia, Z.J. (1998). Iridoid and phenylpropanoid glycosides from Pedicularis artselaeri. Planta Medica, 64(8), 720-723. DOI: 10.1055/s-2006-957565.
  • [10] Li, M., He, X., Tao, R., Cao, X. (2014). Phytochemistry and pharmacologyof the genus Pedicularis used in traditional Chinese medicine. The American Journal of Chinise Medicine, 42, 1071-95. https://doi.org/10.1142/S0192415X14500670.
  • [11] Şen, B., Gürdal, B., Taşkın, T., Hacıoğlu, M., Bozkurt Güzel, Ç., Tufan, S., Mat, A. (2017). Pedicularis condensata Türüne ait Anatomi ve Aktivite Çalışmaları. Marmara Pharmaceutical Journal, 21(3), 485-492.
  • [12] Khodaiea, L., Delazara, A., Lotfipour, F., Nazemiyehc, Nazemiyeh, H. (2012). Antioxidant and antimicrobial activity of Pedicularis sibthorpii Boiss. and Pedicularis wilhelmsiana Fisch ex. Advanced Pharmaceutical Bulletin, 2(1), 89-92. https://doi.org/10.5681/apb.2012.012.
  • [13] Kumarasamy, Y., Byres, M., Cox, P.J., Jaspars, M., Nahar, L., Sarker, S.D. (2007). Screening seeds of some Scottish plants for free radical scavenging activity. Phytotherapy Resarch, 21 (7), 615-621. https://doi.org/10.1002/ptr.2129.
  • [14] Zheng, R.L., Wang, P.F., Li, J., Liu, Z.M., Jia, Z.J. (1993). Inhibition of the autoxidation of linoleic acid by phenylpropanoid glycosides from Pedicularis in micelles. Chemistry and Physics of Lipids, 65(2), 151-154. https://doi.org/10.1016/0009-3084(93)90048-8.
  • [15] Scalbert, A., Johnson, I.T., Saltmarsh, M. (2005). Polyphenols: antioxidants and beyond. American Journal of Clinical Nutrition, 81(suppl), 215S-217S. https://doi.org/10.1093/ajcn/81.1.215S.
  • [16] Hosoya, T., Yun, Y.S., Kunugi, A. (2008). Antioxidant phenylpropanoid glycosides from the leaves of Wasabia japonica. Phytochemistry, 69, 827-832. https://doi.org/10.1016/j.phytochem.2007.08.021.
  • [17] Ahmad, I., Ahmad, N., Wang, F. (2009). Antioxidant phenylpropanoid glycosides from Buddleja davidii. Journal of Enzyme Inhibition and Medicinal Chemistry, 24(4), 993-997. https://doi.org/10.1080/14756360802565072.
  • [18] Biao, C.H., Hua, T.N., Sheng, P.C. (2009). Progress in research on Pedicularis plants. China Journal of Chinese Materia Medica, 34(19), 2536-2546.
  • [19] Zhu, M., Tan, N., Zhu, H., Zeng, G., He, W., Yu, B., Chen, X. (2010). Anti-sports anaemia effects of verbascoside and martynoside in mice. International Journal of Sports Medicine, 31(8), 537- 541. DOI: 10.1055/s-0030-1254115.
  • [20] Moreno-Escobar, J.A., Bazaldúa, S., Villarreal, M.L., Bonilla-Barbosa, J.R., Mendoza, S., Rodríguez-López, V. (2011). Cytotoxic and antioxidant activities of selected Lamiales species from Mexico. Pharmaceutical Biology, 49(12), 1243–1248. https://doi.org/10.3109/13880209.2011.589454.
  • [21] Turker, A.U., Yildirim, A.B., Taş, I., Ozkan, E., Turker, H. (2021). Evaluation of some traditional medicinal plants: phytochemical profile, antibacterial and antioxidant potential. Romanian Biotechnological Letters, 26(2), 2499-2510. DOI: 10.25083/rbl/26.2/2499.2510 https://doi.org/10.25083/rbl/26.2/2499.2510.
  • [22] Yatoo, M.I., Dimri, U., Gopalakrishan, A., Saminathan, M., Dhama, K., Mathesh, K., Saxena, A., Gopinath, D., Husain, S. Antidiabetic and oxidative stress ameliorative potential of ethanolic extract of Pedicularis longiflora Rudolph. International Journal of Pharmacology, 12(3), 177-187, 2016. https://doi.org/10.3923/ijp.2016.177.187.
  • [23] Lee, Y.M., Bae, J.H., Jung, H.Y., Kim, J.H., Sik, D. (2011). Antioxidant activity in water and methanol extracts from Korean edible wild plant. Journal of the Korean Society of Food Science and Nutrition, 40(1), 29-36.
  • [24] Lan, Y., Chi, X., Zhou, G., Zhao, X. (2018). Antioxidants from Pedicularis longiflora var. tubiformis (Klotzsch) P. C. Tsoong. Record of Natural Products, 12(4), 332-339. http://doi.org/10.25135/rnp.35.17.08.142.
  • [25] Dulger, B., Ugurlu, E. (2005). Evaluation of antimicrobial activity of some endemic scrophulariaceae members from Turkey. Pharmaceutical Biology, 43(3), 275–279. https://doi.org/10.1080/13880200590928870.
There are 25 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Research Articles
Authors

Nagehan Saltan 0000-0002-1207-909X

Zeynep Gülcan 0000-0002-4379-3253

Gökalp İşcan 0000-0003-1210-0490

Yavuz Bülent Köse 0000-0002-3060-7271

Early Pub Date December 8, 2023
Publication Date December 15, 2023
Submission Date March 24, 2023
Acceptance Date October 21, 2023
Published in Issue Year 2023 Volume: 16 Issue: 3

Cite

APA Saltan, N., Gülcan, Z., İşcan, G., Köse, Y. B. (2023). Antioxidant and anticandidal effects of Pedicularis comosa L. var. acmodonta Boiss. Biological Diversity and Conservation, 16(3), 224-228. https://doi.org/10.46309/biodicon.2023.1270516
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