Research Article
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The Association of Vitamin D Insufficiency/Deficiency with Metabolic Syndrome, Quality of Life and Depression in Postmenopausal Women

Year 2024, Volume: 13 Issue: 1, 95 - 104, 20.03.2024

Sefa Can Küçük Artun Yıbar Güler Saltıklar Semra Beynel

https://doi.org/10.53424/balikesirsbd.1301296

Abstract

Objective: This cross-sectional study aimed to assess the association of vitamin D insufficiency/deficiency with metabolic syndrome risk factors, quality of life, and depression in postmenopausal women aged 50 years and older. Materials and Metods: The study was conducted with women (n=165) who attended a handicraft course in Bursa Province, Turkey, in March 2019. At the initial visit, blood samples were obtained from the individuals, and the study continued with 150 participants whose serum 25-hydroxyvitamin D (25(OH)D) levels lower than 30 ng/mL and met the research criteria. At the second visit, the subjects were questioned about their general characteristics, quality of life, and depression. In addition to the questionnaire, metabolic syndrome was defined according to the diagnostic criteria of the International Diabetes Federation, and waist circumference and blood pressure measurements were made for each participant. Results: The prevalences of vitamin D insufficiency and deficiency in the participants were 21.3% and 78.7, respectively. When compared to the women with vitamin D insufficiency, those with vitamin D deficiency displayed a significantly higher metabolic syndrome prevalence (46.6% vs 18.8%), waist circumference, blood pressure, and fasting blood glucose levels, and significantly lowered high density lipoprotein cholesterol levels (P<0.05). Furthermore, the differences observed between the women with vitamin D deficiency/insufficiency for physical function, energy level/vitality, mental and general health, which are sub parameters of the quality of life scale, and depression and anxiety scores, were also statistically significant (P<0.05). Conclusion: It was concluded that low vitamin D levels in postmenopausal women may be associated with metabolic syndrome, low quality of life, and depression.

Keywords

vitamin d cholesterol waist circumference depression anxiety

Thanks

We Thank Nazife ELBUKEN for her contribution to BP measurement and taking blood samples for biochemical analysis and Semra MACIT for her assistance in the biochemical analysis of blood samples.

References

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  • Al-Dabhani, K., Tsilidis, K .K., Murphy, N., Ward, H. A., Elliott, P., Riboli, E., et al. (2017). Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population. Nutrition & Diabetes, 7 (4), e263. https://doi.org/10.1038/nutd.2017.14.
  • Al-Yamata, F. I., AlOtaibi, F., Al-Bader, M. D., & Al-Shoumer K. A. (2019). The effect of clothing on vitamin D status, bone turnover markers, and bone mineral density in young Kuwaiti females. International Journal of Endocrinology, 6794837. https://doi.org/10.1155/2019/6794837.
  • Atli, T., Gullu, S., Uysal, A .R., & Erdogan, G. (2005). The prevalence of vitamin D deficiency and effects of ultraviolet light on vitamin D levels in elderly Turkish population. Archives of Gerontology and Geriatrics, 40(1), 53-60. https://doi.org/10.10106/j.archger. 2004.05.006.
  • Basaran, S., Guzel, R., Coskun-Benlidayi, I., & Guler-Uysal, F. (2007). Vitamin D status: effects on quality of life in osteoporosis among Turkish women. Quality of Life Research, 16(9), 1491-9. https://doi.org/ 10.1007/s11136-007-9257-6.
  • Boulkrane, M. S., Fedotova, J., Kolodyaznaya, V., Micale, V., Drago, F., Tol, A .J. M., et al. (2020). Vitamin D and depression in women: a mini-review. Current Neuropharmacology, 18(4), 288-300. https://doi.org/10.2174/1570159X17666191108111120
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  • Brock, K., Huang, W. Y., Fraser, D. R., Ke, L., Tseng, M., Stolzenberg-Solomon, R., et al. (2010). Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women. The Journal of Steroid Biochemistry and Molecular Biology, 121(1-2), 462-6. https://doi.org/10.1016/j.jsbmb.2010.03.091.
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  • Chiang, J. M., Stanczyk, F. Z., & Kanaya, A. M. (2018). Vitamin D levels, body composition, and metabolic factors in Asian Indians: results from the metabolic syndrome and atherosclerosis in south Asians living in America pilot study. Annals of Nutrition & Metabolism, 72(3): 223-30. https://doi.org/10. 1159/000487272.
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  • Kimlin, M., Harrison, S., Nowark, M., Moore, M., Brodie, A., & Lang, C. (2007). Does a high UV environment ensure adequate vitamin D status? Journal of Photochemistry and Photobiology, 89(2-3), 139-47. https://doi.org/10.1016/j.jphotobiol.2007.09.008.
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  • Marsman, D., Belsky, D. W., Gregori D., Johnson, M. A., Dog, T. L., Meydani, S., et al, (2018). Healthy ageing: the natural consequences of good nutrition- a conference report. European Journal of Nutrition, 57(2), 15-34. https://doi.org/10.1007/s00394-018 1723-0.
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  • Motsinger, S., Lazovich, D., MacLehose, R. F., Torkelson, C. J., & Robien, K. (2012). Vitamin D intake and mental health-related quality of life in older women: the lowa Women’s Health Study. Maturitas, 71(3), 267-73. https://doi.org/10.1016/j.maturitas.2011.12. 005.
  • Mousavi, S. E., Amini, H., Heydarpour, P., Chermahini, F. A., & Godderis, L. (2019). Air pollution, environmental chemicals, and smoking may trigger vitamin D deficiency: Evidence and potential mechanisms. Environment International, 122, 67-90. https://doi.org/10.1016/j.envint.2018.11.052.
  • Musazadeh, V., Keramati, M., Ghalichi, F., Kavyani, Z., Ghoreishi, Z., Alras, K. A., et al. (2023). Vitamin D protects against depression: Evidence from an umbrella meta-analysis on interventional and observational meta-analyses. Pharmacological Research, 187, 106605. https://doi.org/10.1016 /j.phrs.2022.106605.
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Year 2024, Volume: 13 Issue: 1, 95 - 104, 20.03.2024

Sefa Can Küçük Artun Yıbar Güler Saltıklar Semra Beynel

https://doi.org/10.53424/balikesirsbd.1301296

Abstract

References

  • Alaklabi, A. M., & Alsharairi, N. A. (2018). Current evidence on vitamin D deficiency and metabolic syndrome in obese children: what does the evidence from Saudi Arabia tell us? Children (Basel), 5(1), 11. https://doi.org/10.3390/children5010011.
  • Al-Dabhani, K., Tsilidis, K .K., Murphy, N., Ward, H. A., Elliott, P., Riboli, E., et al. (2017). Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population. Nutrition & Diabetes, 7 (4), e263. https://doi.org/10.1038/nutd.2017.14.
  • Al-Yamata, F. I., AlOtaibi, F., Al-Bader, M. D., & Al-Shoumer K. A. (2019). The effect of clothing on vitamin D status, bone turnover markers, and bone mineral density in young Kuwaiti females. International Journal of Endocrinology, 6794837. https://doi.org/10.1155/2019/6794837.
  • Atli, T., Gullu, S., Uysal, A .R., & Erdogan, G. (2005). The prevalence of vitamin D deficiency and effects of ultraviolet light on vitamin D levels in elderly Turkish population. Archives of Gerontology and Geriatrics, 40(1), 53-60. https://doi.org/10.10106/j.archger. 2004.05.006.
  • Basaran, S., Guzel, R., Coskun-Benlidayi, I., & Guler-Uysal, F. (2007). Vitamin D status: effects on quality of life in osteoporosis among Turkish women. Quality of Life Research, 16(9), 1491-9. https://doi.org/ 10.1007/s11136-007-9257-6.
  • Boulkrane, M. S., Fedotova, J., Kolodyaznaya, V., Micale, V., Drago, F., Tol, A .J. M., et al. (2020). Vitamin D and depression in women: a mini-review. Current Neuropharmacology, 18(4), 288-300. https://doi.org/10.2174/1570159X17666191108111120
  • Buyukuslu, N., Esin, K., Hizli, H., Sunal, N., Yigit, P., & Garipagaoglu, M. (2014). Clothing preference affects vitamin D status of young women. Nutrition Research, 34(8), 688-93. https://doi.org/10.1016/j.nutres.2014. 07.012.
  • Brock, K., Huang, W. Y., Fraser, D. R., Ke, L., Tseng, M., Stolzenberg-Solomon, R., et al. (2010). Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women. The Journal of Steroid Biochemistry and Molecular Biology, 121(1-2), 462-6. https://doi.org/10.1016/j.jsbmb.2010.03.091.
  • Carlson, C. R., Uriu-Adams, J. Y., Chambers, C. D., Yevtushok, L., Zymak-Zakutnya, N., Chan, P. H. et al (2017). Vitamin D deficiency in pregnant Ukrainian women: effects of alcohol consumption on vitamin D status. Journal of the American College of Nutrition, 36(1), 44-56. https://doi.org/10.1080/07315724 .2016.1174091.
  • Cheng, T. Y. D., Millen, A. E., Wactawski-Wende, J., Beresford, S. A. A., LaCroix, A. Z., Zheng, Y., et al. (2014). Vitamin D intake determines vitamin D status of postmenopausal women, particulary those with limited sun exposure. The Journal of Nutrition, 144 (5), 681-89. https://doi.org/10.3945/jn.113.183541.
  • Chiang, J. M., Stanczyk, F. Z., & Kanaya, A. M. (2018). Vitamin D levels, body composition, and metabolic factors in Asian Indians: results from the metabolic syndrome and atherosclerosis in south Asians living in America pilot study. Annals of Nutrition & Metabolism, 72(3): 223-30. https://doi.org/10. 1159/000487272.
  • Civelek, G. M., Pekyavas, N. O., Cetin, N., Cosar, S. N., & Karatas, M. (2014). Association of vitamin D deficiency with muscle strength and quality of life in postmenopausal women. Climacteric, 17(4): 472-7. https://doi.org/10.3109/13697137.2014.898265.
  • Craig, C. L., Marshall, A. L., Sjöström, M., Bauman, A. E., Booth, M. L., Ainsworth, B. E., et al. (2003). International physical activity questionnaire: 12-country reliability and validity. Medicine and Science in Sports and Exercise, 35(8): 1381-95. https://doi.org/10.1249/01.MSS.000008924.61453
  • Ecemis, G., & Atmaca, A. (2012). Quality of life in premenopausal women with vitamin D deficiency and Vitamin D insufficiency. Endocrine Abstracts, 29: 225.
  • Ersoy, N., & Ersoy, G. (2017). D vitamini yetersizliği ve depresyon: Ne yapabiliriz? Hacettepe Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 4(3), 1-4 (in Turkish with an abstract in English).
  • Faraji, S., & Alizadeh, M. (2020). Mechanistic effects of vitamin D supplementation on metabolic syndrome components in patients with or without vitamin D deficiency. Journal of Obesity & Metabolic Syndrome, 29(4) 270-80.
  • Feng, X., Guo, T., Wang, Y., Kang, D., Che, X., Zhang, H., et al. (2016). The vitamin D status and its effects on life quality among the elderly in Jinan, China. Archives of Gerontology and Geriatrics, 62: 26-9. https://doi.org/10.1016/j.archger.2015.09.002.
  • Grimnes, G., Almaas, B., Eggen, A. E., Emaus, N., Figenschau, Y., Hopstock, L. A., et al. (2010). Effect of smoking on the serum levels of 25-hydroxyvitamin D depens on the assay employed. European Journal of Endocrinology, 163(2), 339-48. https://doi.org/10. 1530/EJE-10-0150.
  • Haimi, M., & Kremer, R. (2017). Vitamin D deficiency/insufficiency from childhood to adulthood: insights from a sunny country. World Journal of Clinical Pediatrics, 6(1): 1-9. https://doi.org/10.5409 /wjcp.v6.i1.1.
  • He, S., & Hao, X. (2019). The effect of vitamin D3 on blood pressure in people with vitamin D deficiency. Medicine, 98(19), e15284. https://doi.org/10.1097/MD .0000000000015284.
  • Hoffmann, M. R., Senior, P. A., & Mager, D. R. (2015). Vitamin D supplementation and health-related quality of life: a systematic review of the literature. Journal of the Academy of Nutrition and Dietetics, 115(3), 406-18. https://doi.org/10.1016/j.jand.2014.10.023.
  • Huang, R., Wang, K., & Hu, J. (2016). Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials. Nutrients, 8(8), 483. https://doi.org/10.3390/nu8080483.
  • International Diabetes Federation (IDF). (2022, April 27). The IDF consensus worldwide definition of the metabolic syndrome 2006. Available from: https://www.idf.org/component/attachments/attachments.html?id=705&task=download
  • Jiang, C. Q., Chan, Y. H., Xu, L., Jin, Y. L., Zhu, T., Zhang, W. S., et al. (2016). Smoking and serum vitamin D in older Chinese people: cross-sectional analysis based on the Guangzhou Biobank Cohort Study. BMJ Open, 6(6), e010946. https://doi.org/10.1136/bmjopen-2015-010946.
  • Kaur, J., Ferguson, S. L., Freitas E, et al (2019). Association of vitamin D status with chronic disease risk factor and cognitive dysfunction in 50-70 year old adults. Nutrients, 11(1), 141. https://doi.org/10.3390/ nu11010141.
  • Kimlin, M., Harrison, S., Nowark, M., Moore, M., Brodie, A., & Lang, C. (2007). Does a high UV environment ensure adequate vitamin D status? Journal of Photochemistry and Photobiology, 89(2-3), 139-47. https://doi.org/10.1016/j.jphotobiol.2007.09.008.
  • Koçyiğit, H., Aydemir, Ö., Fişek, G., Ölmez, N. & Memiş A. K. (1999). Form-36 (KF-36)’nın Türkçe versiyonunun güvenilirliği ve geçerliliği. İlaç ve Tedavi Dergisi, 12(2), 102-106.
  • Latic, N., & Erben, R. G. (2020). Vitamin D and cardiovascular disease, with emphasis on hypertension, atherosclerosis, and hearth failure. International Journal of Molecular Sciences, 21(18), 6483. https://doi.org/10.3390/ijms21186483.
  • Lee, C., & Longo, V. (2016). Dietary restriction with and without caloric restriction for healthy aging. F1000Research, 5, 1117. https://doi.org/10.12688/f 1000research.7136.1.
  • Liu, L., Cao, Z., Lu, F., Liu, Y., Lv, Y., Qu, Y., et al. (2020). Vitamin D deficiency and metabolic syndrome in elderly Chinese individuals: evidence from CLHLS. Nutrition & Metabolism, 17, 58. “https://doi.org/10. 1186/s12986-020-004793.
  • Lokki, A. I., Heikkinen-Eloranta, J., Öhman, H., Heinonen, S., Surcel, H. M ., & Nielsen, H. S. (2020). Smoking during pregnancy reduces vitamin D levels in a Finnish birth register cohort. Public Health Nutrition, 23(7), 1273-7. https://doi.org/10.1017/S1368980018003932.
  • Marsman, D., Belsky, D. W., Gregori D., Johnson, M. A., Dog, T. L., Meydani, S., et al, (2018). Healthy ageing: the natural consequences of good nutrition- a conference report. European Journal of Nutrition, 57(2), 15-34. https://doi.org/10.1007/s00394-018 1723-0.
  • McKinney, K., Breitkopf, C. R., & Berenson, A. B. (2008). Association of race, body fat and season with vitamin D status among young women: a cross-sectional study. Clinical Endocrinology, 69(4), 535-41. https://doi.org/ 10.1111/j.13652265.2008.03233.x.
  • McMullan, C. J., Borgi, L., Curhan, G. C., Fisher, N., Forman, J. P. (2017). The effect of vitamin D on renin-angiotensin system activation and blood pressure: a randomized control trial. Journal of Hypertension, 35(4), 822-9. https://doi.org/10.1097 /HJH.0000000000001220.
  • Motsinger, S., Lazovich, D., MacLehose, R. F., Torkelson, C. J., & Robien, K. (2012). Vitamin D intake and mental health-related quality of life in older women: the lowa Women’s Health Study. Maturitas, 71(3), 267-73. https://doi.org/10.1016/j.maturitas.2011.12. 005.
  • Mousavi, S. E., Amini, H., Heydarpour, P., Chermahini, F. A., & Godderis, L. (2019). Air pollution, environmental chemicals, and smoking may trigger vitamin D deficiency: Evidence and potential mechanisms. Environment International, 122, 67-90. https://doi.org/10.1016/j.envint.2018.11.052.
  • Musazadeh, V., Keramati, M., Ghalichi, F., Kavyani, Z., Ghoreishi, Z., Alras, K. A., et al. (2023). Vitamin D protects against depression: Evidence from an umbrella meta-analysis on interventional and observational meta-analyses. Pharmacological Research, 187, 106605. https://doi.org/10.1016 /j.phrs.2022.106605.
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Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Sefa Can Küçük 0000-0002-0919-5874

Artun Yıbar 0000-0001-9510-5734

Güler Saltıklar 0000-0003-1060-322X

Semra Beynel 0000-0002-7245-0866

Publication Date March 20, 2024
Submission Date May 23, 2023
Published in Issue Year 2024 Volume: 13 Issue: 1

Cite

APA Küçük, S. C., Yıbar, A., Saltıklar, G., Beynel, S. (2024). The Association of Vitamin D Insufficiency/Deficiency with Metabolic Syndrome, Quality of Life and Depression in Postmenopausal Women. Balıkesir Sağlık Bilimleri Dergisi, 13(1), 95-104. https://doi.org/10.53424/balikesirsbd.1301296
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