Review
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Propolisin İnsan Sağlığına Etkileri

Year 2014, Volume: 24 Issue: 2, 41 - 49, 20.12.2014

Banu Yücel Erkan Topal Eren Akçiçek Mustafa Kösoğlu

Abstract




Son
yıllarda insan sağlığına yönelik kullanılan ilaçların etkinliğinin azalması,
yan etkilerinin ortaya çıkması ve artması, ekonomik kayıpların meydana gelmesi
gibi birçok olumsuzluğun sonucu olarak doğal ürünlere giderek artan bir yönelim
oluşmaya başlamıştır. Bu yönelimin en çok yaşandığı grupların başında arı
ürünleri gelmektedir. Arı ürünleri antibakteriyel, antioksidan, antifungal,
antiinflamatuar, antitümör, antiseptik özellikleri nedeniyle tıp, ilaç ve gıda
sektörü başta olmak üzere kamuoyunda oldukça ilgi görmektedir. Dünya’nın pek
çok ülkesinde arı ürünleri ile tedavi (apiterapi) uygulamaları yapılmakta ve
önemli tıbbi destek olarak saygın bilim otoritelerince kabul görmektedir.
Ülkemizde ise son zamanlarda gündeme gelen apiterapi ve arı ürünleri
tüketiciler tarafından takip edilmekte ve yeni bir pazar oluşmaktadır. Arı
ürünlerinde en yoğun çalışmalar “doğal antibiyotik” olarak kabul edilen
propolisin üzerinde yürütülmektedir.  Bu
derlemede, propolisin insan sağlığı üzerine etkilerine yönelik yapılmış
çalışmaların bir kısmı belli başlıklar altında verilerek, sağlık üzerine etkisi
vurgulanmaya çalışılmış, konu ile ilgili farkındalığın artırılması ve konuya
yönelik potansiyel çalışmalara ışık tutması hedeflenmiştir.

Keywords

Propolis bal arısı apiterapi sağlık arı ürünü

References

  • Ahn, M. R., S. W. Kim, S. Kumazawa, and T. Ohta. 2013. Artepillin C suppresses aAngiogenesis by inhibiting tube-formation and inducing apoptosis of endothelial cells. Journal of Food and Nutrition Research 1 (5): 92-96.
  • Aksoy, S., F. Armutçu, and M. R. Yiğitoğlu. 2011. Using of caffeic acid phenetil ester (CAPE) the active substance of propolis in some neurologic disease and emergency. Spatula DD. 1 (1): 37-42.
  • Aso, K., S. Kanno, T. Tadano, S. Satoh, and M. Ishikawa. 2004. Inhibitory effect of propolis on the growth of human leukemia U937. Biol Pharm Bull. 27: 727-730.
  • Balata, G., H. M. El Nahas, and S. Radwan. 2014. Propolis organogel as a novel topical delivery system for treating wounds. Drug Delivery 21 (1): 55-61.
  • Bankova, V. 2005. Recent trends and important developments in propolis research. eCAM. 2 (1): 29-32.
  • Barak, V., S. Birkenfeld, and T. Halperin. 2002. The effect of herbal remedies on the production of human inflammatory and anti-inflammatory cytokines. Isr Med Assoc. J. 4 (11 Suppl): 919-922.
  • Barlak, Y., O. Değer, M. Çolak, S. C. Karataylı, A. M. Bozdayı, and F. Yücesan. 2011. Effect of Turkish propolis extracts on proteome ofprostate cancer cell line. Proteome Science 9: 74.
  • Basista, K. M., and B. Filipek. 2012. Allergy to propolis in Polish beekeepers. Postep Derm Alergol. 6: 440-445.
  • Biray, Ç., C. Gündüz, B. Yılmaz, F. Şahin, and N. Toğçuoğlu. 2006. The evaluation of cytotoxic and apoptotic effect of propolis and its extracts caffeic acid phenethyl ester and cinnamic acid in human acute t-cell lymphoblastic leukemia cell line (CCRF-CEM] Ege Tıp Dergisi 45 (2) : 83-92.
  • Black, R. J. 2005. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp Dermatol. 30 (1): 91-92.
  • Borrelli, F., P. Maffia, and L. Pinto. 2002. Phytochemical compounds involved in the anti inflammatory effect of propolis extract. Fitoterapia 73 (1): 53-63.
  • Botushanov, P. I., G. I. Grigorov, and G. A. A. Aleksandrov. 2001. Clinical study of a silicate toothpaste with extract from propolis. Folia Med (Plovdiv). 43 (1-2): 28-30.
  • Boyanova, L., S. Derejian, R. Koumanova, N. Katsarov, G. Gergova, I. Mitov, and Z. Krastev. 2003. Inhibition of helicobacter pylori growth in vitro by Bulgarian propolis: preliminary report. Journal of Medical Microbiology 52 (5): 417-419.
  • Camargo, M. S., A. M. F. A. Resende, P. K. Boldrin, and C. R. Cardoso. 2013. Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis. BMC Complement Altern Med. 31 (13): 201.
  • Ciaceri, G., and G. Attaguile.1972. Influenza della luteolina, ded'apigenina e dell'acace-sull'ulcera gastrica sperimentale. Minerva Med. 63 (29): 1665-1668.
  • Cicala, C., S. Morello, and C. Iorio. 2003. Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sci. 73 (1): 73-80.
  • Cohen, H. A., I. Varsano, E. Kahan, M. Sarrell, and Y. Uziel. 2004. Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in Preventing Respiratory Tract Infections in Children. Arch Pediatr Adolesc Med. 158: 217-221.
  • Crişan, B., C. N. Zaharia, F. Popovici, V. Jucu, O. Belu, C. Dascălu, A. Mutiu, and A. Petrescu. 1995. Natural propolis extract NIVCRISOL in the treatment of acute and chronic rhinopharyngitis in children. Romanian Journal of Virology 46 (3-4): 115-133.
  • Daidone, M. G., R. Silvestrini, B. Velentinis, P. G. Mezzanotte, P. Squicciarini, S. Orefice, and B.Salvadori. 1990. Proliferative activity of primary breast cancer and of synchronous lymph node metastases evaluated by 3H- Tyhmidine labelling index. Cell Tissue Kinet. 23: 401-8.
  • Erdem, G. B., and S. Ölmez. 2004. Inhibitory Effect of Bursa Propolis on Dental Caries Formation in Rats Inoculated with Streptococcus sobrinus. Turk J. Zool. 28: 29-36.
  • Eroğlu, H. E., A. Tatlışen, and Y. Özkul. 2004. Effects of propolis and mitomycın-C on micronucleusin tissue cultures of bladder cancer. Erciyes Üniversitesi Sağlık Bilimleri Dergisi 13 (2): 15-20.
  • Farooqui, T., and A. A. Farooqui. 2012. Beneficial effects of propolis on human health and neurological diseases. Frontiers in Bioscience E4: 779-793.
  • Focht, J., S. H. Hansen, J. V. Nielsen, A. Van Den Berg-Segers, and R. Riezler. 1993. Bactericidal effect of propolis in vitro against agents causing upper respiratory tract infections. Arzneimittel-Forschung 43 (8): 921-923.
  • Fuliang, H. U., H. R. Hepburn, H. Xuan, M. Chen, S. Daya, and S. E. Radloff. 2005. Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacol Res. 51 (2): 147-52.
  • Gafar, M., M. Puchita, B. Popa, and G. Pambuccian. 1989. Anatomo-clinical studies on contraindications of biological treatment of the dental pulp in some cronic general diseases. Rev Chir Oncol Radiol ORL Oftalmol Stomatol Ser Stomatol. 36 (2): 99-108.
  • Ghisalberti, E. L. 1979. Propolis: A Review. Bee World 60 (2): 59-84.
  • Güney, M., B. Oral, N. Karahan, and T. Mungan. 2007. Protective effect of caffeic acid phenethyl ester (CAPE) on fluoride-induced oxidative stress and apoptosis in rat endometrium. Environ Toxicol Pharmacol. Sep. 24 (2): 86-91.
  • Hartwich, A., J. Legutko, and J. Wszolek. 2000. Propolis: its properties and administration to patients treated for some surgical diseases. Przegl Lek. 57: 191-194.
  • Hubbezoğlu, İ., Ü. Özan, and Z. Sümer. 2011. Effects on Escherichia coli of solutions containing propolis and potassium titanium phosphate laser in root canal irrigation. Atatürk Üniv. Diş Hek. Fak. Derg. 21 (1): 15-21.
  • Imhof, M., M. Lipovac, Ch. Kurz, J. Barta, H. C. Verhoeven, and J. C.Huber. 2005. Propolis solution for the treatment of chronic vaginitis. Int. J. Gynaecol Obstet. May 89 (2): 127-32.
  • Jaganathan, S. K., and M. Mandal. 2010. Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p 53 in honey-induced apoptosis, Invest New Drugs 28: 624-633.
  • Kakino, M., H. Izuta, K. Tsuruma, Y. Araki, M. Shimazawa, K. Ichihara, and H. Hara. 2012. Laxative effects and mechanism of action of Brazilian green propolis. BMC Complementary and Alternative Medicine 12: 192.
  • Kamburoğlu, K., and T. Özen. 2011. Analgesic effect of Anatolian propolis in mice. Ağrı. 23 (2): 47-50.
  • Koru, Ö., F. Toksoy, C. H. Açikel, Y. M. Tunca, and M. Baysallar. 2007. In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens. Anaerobe 13 (3-4): 140–145.
  • Kurt, F. Ö., S. H. Vatansever, K. Sorkun, S. I. D. Gürhan, and E. Türkoz. 2010. Inhibitory effects of propolis on human osteogenic sarcoma cell proliferation mediated by caspase patway. Kafkas Univ. Vet. Fak. Dergisi 16 (3): 397-404.
  • Lavigne, J. P., X. Vitrac,L. Bernard, F. Bruyère, and A. Sotto. 2011. Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. BMC Research Notes 4 (1): 522.
  • Lisičić, D., V. Benković, D. Đikić, A. S. Blažević, J. Mihaljević, N. Oršolić, and A. H. Knežević. 2014. Addition of propolis to irinotecan therapy prolongs survival in ehrlich ascites tumor-bearing mice. Cancer Biotherapy & Radiopharmaceuticals 29 (2): 62-69.
  • Luo, J., J. W. Soh, W. Q. Xing, Y. Mao, T. Matsuno, and I. B. Weinstein. 2001. PM-3, a benzo-gamma-pyran derivative isolated from propolis, inhibits growth of MCF-7 human breast cancer cells, Anticancer Res. 21: 1665-1671.
  • Mahal, N. K., N. Singh, P. M. Thomas, and N. Kakkar. 2013. Effect of three different storage media on survival of periodontal ligament cells using collagenase-dispase assay. Int. Endod J. Apr. 46 (4): 365-70.
  • Morales, W. F., and J. L. Garbarino. 1997. Clinical evaluation of a new hypoallergic formula of propolis in dressings. Bee Products pp. 101-105.
  • Moreno, M. I. N., M. I. Isla, A. R. Sampietro, and M. A. Vattuone. 2000. Comparison of the freeradical-scavenging activity of propolis from several regions of Argentina. J. Ethnopharmacol 71: 109 -114.
  • Muscat, M. 2013. Use of Propolis chemical and Asian tiger mosquito bites - case report and review. Malta Medical Journal 25 (1): 58-61.
  • Nagai, T., R. İnoue, H. İnoue, and N. Suzuki, N. 2003. Preparation and antioxidant properties of water extract of propolis. Food Chemistry 80 (1): 29–33.
  • Omene, M., M. Kalac, J. Wu, E. Marchi, K. Frenkel, and O. A. Connor. 2013. Propolis and its active component, caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeutic targets via an epigenetically mediated mechanism of action. J. Cancer Sci Ther. 5 (10): 334-342.
  • Oršolić, N., N. Car, D. Lisicic, V. Benkovic, A. H. Knezevic, D. Dikic, and J. Pertik. 2013. Synergism between propolis and hyperthermal intraperitoneal chemotherapy with cisplatin on ehrlich ascites tumor in mice. J. Pharm. Sci. 102 (12): 4395-405.
  • Özan, F., Z. A. Polat, K. Er, Ü. Ozan, and O. Değer, O. 2007. Effect of propolis on survival of periodontal ligament cells: New storage media for avulsed teeth. Journal of Endodontics 33 (5): 570-573.
  • Özcan, M., A. Ceylan, A. Ünver, and R. Yetişir. 2003. Antifungal effect of pollen and propolis extracts collected from different regions of Turkey. Uludağ Bee Journal August: 27-34.
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  • Paintz, M., and J. Metzner . 1979. Zur lokalanasthetischen wirkung vin propolis und einigen inhaltsstofen. Pharmazie 34: 839-841.
  • Park, Y. K., M. H. Koo, and J. A. Abreu. 1998. Antimicrobial activity of propolis on oral microorganisms. Curr Microbiol. 36 (1): 24-28.
  • Parolia, A., S. M. Thomas, M. Kundabala, and M. Mohan. 2010. Propolis and its potential uses in oral health. International Journal of Medicine and Medical Sciences 2 (7): 210-215.
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  • Vaz Coelho, L. G., E. M. A. Ferreira Bastos, C. C. Resende, P. Silva, C. Mirra, F. Sanches, and O. R. Trindade. 2007. Brazilian green propolis on Helicobacter pylori infection. A pilot clinical study. Helicobacter 12 (5): 572-574.
  • Vynograd, N., I. Vynograd, and Z. Sosnowski. 2000. A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). Phytomedicine 7 (1): 1-6.
  • Wei, X., L. Zhao, Z. Ma, D. M. Holtzman, C. Yan, and R. C. Dodel. 2004. Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. Brain. 127 (12): 2629-35.

Year 2014, Volume: 24 Issue: 2, 41 - 49, 20.12.2014

Banu Yücel Erkan Topal Eren Akçiçek Mustafa Kösoğlu

Abstract

References

  • Ahn, M. R., S. W. Kim, S. Kumazawa, and T. Ohta. 2013. Artepillin C suppresses aAngiogenesis by inhibiting tube-formation and inducing apoptosis of endothelial cells. Journal of Food and Nutrition Research 1 (5): 92-96.
  • Aksoy, S., F. Armutçu, and M. R. Yiğitoğlu. 2011. Using of caffeic acid phenetil ester (CAPE) the active substance of propolis in some neurologic disease and emergency. Spatula DD. 1 (1): 37-42.
  • Aso, K., S. Kanno, T. Tadano, S. Satoh, and M. Ishikawa. 2004. Inhibitory effect of propolis on the growth of human leukemia U937. Biol Pharm Bull. 27: 727-730.
  • Balata, G., H. M. El Nahas, and S. Radwan. 2014. Propolis organogel as a novel topical delivery system for treating wounds. Drug Delivery 21 (1): 55-61.
  • Bankova, V. 2005. Recent trends and important developments in propolis research. eCAM. 2 (1): 29-32.
  • Barak, V., S. Birkenfeld, and T. Halperin. 2002. The effect of herbal remedies on the production of human inflammatory and anti-inflammatory cytokines. Isr Med Assoc. J. 4 (11 Suppl): 919-922.
  • Barlak, Y., O. Değer, M. Çolak, S. C. Karataylı, A. M. Bozdayı, and F. Yücesan. 2011. Effect of Turkish propolis extracts on proteome ofprostate cancer cell line. Proteome Science 9: 74.
  • Basista, K. M., and B. Filipek. 2012. Allergy to propolis in Polish beekeepers. Postep Derm Alergol. 6: 440-445.
  • Biray, Ç., C. Gündüz, B. Yılmaz, F. Şahin, and N. Toğçuoğlu. 2006. The evaluation of cytotoxic and apoptotic effect of propolis and its extracts caffeic acid phenethyl ester and cinnamic acid in human acute t-cell lymphoblastic leukemia cell line (CCRF-CEM] Ege Tıp Dergisi 45 (2) : 83-92.
  • Black, R. J. 2005. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp Dermatol. 30 (1): 91-92.
  • Borrelli, F., P. Maffia, and L. Pinto. 2002. Phytochemical compounds involved in the anti inflammatory effect of propolis extract. Fitoterapia 73 (1): 53-63.
  • Botushanov, P. I., G. I. Grigorov, and G. A. A. Aleksandrov. 2001. Clinical study of a silicate toothpaste with extract from propolis. Folia Med (Plovdiv). 43 (1-2): 28-30.
  • Boyanova, L., S. Derejian, R. Koumanova, N. Katsarov, G. Gergova, I. Mitov, and Z. Krastev. 2003. Inhibition of helicobacter pylori growth in vitro by Bulgarian propolis: preliminary report. Journal of Medical Microbiology 52 (5): 417-419.
  • Camargo, M. S., A. M. F. A. Resende, P. K. Boldrin, and C. R. Cardoso. 2013. Evaluation of estrogenic, antiestrogenic and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis. BMC Complement Altern Med. 31 (13): 201.
  • Ciaceri, G., and G. Attaguile.1972. Influenza della luteolina, ded'apigenina e dell'acace-sull'ulcera gastrica sperimentale. Minerva Med. 63 (29): 1665-1668.
  • Cicala, C., S. Morello, and C. Iorio. 2003. Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sci. 73 (1): 73-80.
  • Cohen, H. A., I. Varsano, E. Kahan, M. Sarrell, and Y. Uziel. 2004. Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in Preventing Respiratory Tract Infections in Children. Arch Pediatr Adolesc Med. 158: 217-221.
  • Crişan, B., C. N. Zaharia, F. Popovici, V. Jucu, O. Belu, C. Dascălu, A. Mutiu, and A. Petrescu. 1995. Natural propolis extract NIVCRISOL in the treatment of acute and chronic rhinopharyngitis in children. Romanian Journal of Virology 46 (3-4): 115-133.
  • Daidone, M. G., R. Silvestrini, B. Velentinis, P. G. Mezzanotte, P. Squicciarini, S. Orefice, and B.Salvadori. 1990. Proliferative activity of primary breast cancer and of synchronous lymph node metastases evaluated by 3H- Tyhmidine labelling index. Cell Tissue Kinet. 23: 401-8.
  • Erdem, G. B., and S. Ölmez. 2004. Inhibitory Effect of Bursa Propolis on Dental Caries Formation in Rats Inoculated with Streptococcus sobrinus. Turk J. Zool. 28: 29-36.
  • Eroğlu, H. E., A. Tatlışen, and Y. Özkul. 2004. Effects of propolis and mitomycın-C on micronucleusin tissue cultures of bladder cancer. Erciyes Üniversitesi Sağlık Bilimleri Dergisi 13 (2): 15-20.
  • Farooqui, T., and A. A. Farooqui. 2012. Beneficial effects of propolis on human health and neurological diseases. Frontiers in Bioscience E4: 779-793.
  • Focht, J., S. H. Hansen, J. V. Nielsen, A. Van Den Berg-Segers, and R. Riezler. 1993. Bactericidal effect of propolis in vitro against agents causing upper respiratory tract infections. Arzneimittel-Forschung 43 (8): 921-923.
  • Fuliang, H. U., H. R. Hepburn, H. Xuan, M. Chen, S. Daya, and S. E. Radloff. 2005. Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus. Pharmacol Res. 51 (2): 147-52.
  • Gafar, M., M. Puchita, B. Popa, and G. Pambuccian. 1989. Anatomo-clinical studies on contraindications of biological treatment of the dental pulp in some cronic general diseases. Rev Chir Oncol Radiol ORL Oftalmol Stomatol Ser Stomatol. 36 (2): 99-108.
  • Ghisalberti, E. L. 1979. Propolis: A Review. Bee World 60 (2): 59-84.
  • Güney, M., B. Oral, N. Karahan, and T. Mungan. 2007. Protective effect of caffeic acid phenethyl ester (CAPE) on fluoride-induced oxidative stress and apoptosis in rat endometrium. Environ Toxicol Pharmacol. Sep. 24 (2): 86-91.
  • Hartwich, A., J. Legutko, and J. Wszolek. 2000. Propolis: its properties and administration to patients treated for some surgical diseases. Przegl Lek. 57: 191-194.
  • Hubbezoğlu, İ., Ü. Özan, and Z. Sümer. 2011. Effects on Escherichia coli of solutions containing propolis and potassium titanium phosphate laser in root canal irrigation. Atatürk Üniv. Diş Hek. Fak. Derg. 21 (1): 15-21.
  • Imhof, M., M. Lipovac, Ch. Kurz, J. Barta, H. C. Verhoeven, and J. C.Huber. 2005. Propolis solution for the treatment of chronic vaginitis. Int. J. Gynaecol Obstet. May 89 (2): 127-32.
  • Jaganathan, S. K., and M. Mandal. 2010. Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p 53 in honey-induced apoptosis, Invest New Drugs 28: 624-633.
  • Kakino, M., H. Izuta, K. Tsuruma, Y. Araki, M. Shimazawa, K. Ichihara, and H. Hara. 2012. Laxative effects and mechanism of action of Brazilian green propolis. BMC Complementary and Alternative Medicine 12: 192.
  • Kamburoğlu, K., and T. Özen. 2011. Analgesic effect of Anatolian propolis in mice. Ağrı. 23 (2): 47-50.
  • Koru, Ö., F. Toksoy, C. H. Açikel, Y. M. Tunca, and M. Baysallar. 2007. In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens. Anaerobe 13 (3-4): 140–145.
  • Kurt, F. Ö., S. H. Vatansever, K. Sorkun, S. I. D. Gürhan, and E. Türkoz. 2010. Inhibitory effects of propolis on human osteogenic sarcoma cell proliferation mediated by caspase patway. Kafkas Univ. Vet. Fak. Dergisi 16 (3): 397-404.
  • Lavigne, J. P., X. Vitrac,L. Bernard, F. Bruyère, and A. Sotto. 2011. Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. BMC Research Notes 4 (1): 522.
  • Lisičić, D., V. Benković, D. Đikić, A. S. Blažević, J. Mihaljević, N. Oršolić, and A. H. Knežević. 2014. Addition of propolis to irinotecan therapy prolongs survival in ehrlich ascites tumor-bearing mice. Cancer Biotherapy & Radiopharmaceuticals 29 (2): 62-69.
  • Luo, J., J. W. Soh, W. Q. Xing, Y. Mao, T. Matsuno, and I. B. Weinstein. 2001. PM-3, a benzo-gamma-pyran derivative isolated from propolis, inhibits growth of MCF-7 human breast cancer cells, Anticancer Res. 21: 1665-1671.
  • Mahal, N. K., N. Singh, P. M. Thomas, and N. Kakkar. 2013. Effect of three different storage media on survival of periodontal ligament cells using collagenase-dispase assay. Int. Endod J. Apr. 46 (4): 365-70.
  • Morales, W. F., and J. L. Garbarino. 1997. Clinical evaluation of a new hypoallergic formula of propolis in dressings. Bee Products pp. 101-105.
  • Moreno, M. I. N., M. I. Isla, A. R. Sampietro, and M. A. Vattuone. 2000. Comparison of the freeradical-scavenging activity of propolis from several regions of Argentina. J. Ethnopharmacol 71: 109 -114.
  • Muscat, M. 2013. Use of Propolis chemical and Asian tiger mosquito bites - case report and review. Malta Medical Journal 25 (1): 58-61.
  • Nagai, T., R. İnoue, H. İnoue, and N. Suzuki, N. 2003. Preparation and antioxidant properties of water extract of propolis. Food Chemistry 80 (1): 29–33.
  • Omene, M., M. Kalac, J. Wu, E. Marchi, K. Frenkel, and O. A. Connor. 2013. Propolis and its active component, caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeutic targets via an epigenetically mediated mechanism of action. J. Cancer Sci Ther. 5 (10): 334-342.
  • Oršolić, N., N. Car, D. Lisicic, V. Benkovic, A. H. Knezevic, D. Dikic, and J. Pertik. 2013. Synergism between propolis and hyperthermal intraperitoneal chemotherapy with cisplatin on ehrlich ascites tumor in mice. J. Pharm. Sci. 102 (12): 4395-405.
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There are 65 citations in total.

Details

Journal Section Makaleler
Authors

Banu Yücel

Erkan Topal

Eren Akçiçek

Mustafa Kösoğlu This is me

Publication Date December 20, 2014
Submission Date July 13, 2017
Published in Issue Year 2014 Volume: 24 Issue: 2

Cite

APA Yücel, B., Topal, E., Akçiçek, E., Kösoğlu, M. (2014). Propolisin İnsan Sağlığına Etkileri. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi, 24(2), 41-49.
AMA Yücel B, Topal E, Akçiçek E, Kösoğlu M. Propolisin İnsan Sağlığına Etkileri. ANADOLU. December 2014;24(2):41-49.
Chicago Yücel, Banu, Erkan Topal, Eren Akçiçek, and Mustafa Kösoğlu. “Propolisin İnsan Sağlığına Etkileri”. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 24, no. 2 (December 2014): 41-49.
EndNote Yücel B, Topal E, Akçiçek E, Kösoğlu M (December 1, 2014) Propolisin İnsan Sağlığına Etkileri. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 24 2 41–49.
IEEE B. Yücel, E. Topal, E. Akçiçek, and M. Kösoğlu, “Propolisin İnsan Sağlığına Etkileri”, ANADOLU, vol. 24, no. 2, pp. 41–49, 2014.
ISNAD Yücel, Banu et al. “Propolisin İnsan Sağlığına Etkileri”. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi 24/2 (December 2014), 41-49.
JAMA Yücel B, Topal E, Akçiçek E, Kösoğlu M. Propolisin İnsan Sağlığına Etkileri. ANADOLU. 2014;24:41–49.
MLA Yücel, Banu et al. “Propolisin İnsan Sağlığına Etkileri”. ANADOLU Ege Tarımsal Araştırma Enstitüsü Dergisi, vol. 24, no. 2, 2014, pp. 41-49.
Vancouver Yücel B, Topal E, Akçiçek E, Kösoğlu M. Propolisin İnsan Sağlığına Etkileri. ANADOLU. 2014;24(2):41-9.
29899ANADOLU Journal by Aegean Agricultural Research Institute is licensed under CC BY-NC-ND 4.0  

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