The Effects of Diet and Microbiota on Attacks in Familial Mediterranean Fever

M. Gizem Keser; Nurhan Unusan

doi:10.53394/akd.1010790

Review

The Effects of Diet and Microbiota on Attacks in Familial Mediterranean Fever

Year 2023, Volume: 9 Issue: 2, 206 - 212, 01.05.2023

M. Gizem Keser Nurhan Unusan

https://doi.org/10.53394/akd.1010790

Abstract

Familial Mediterranean fever (FMF) is one of the common autoinflammatory diseases with autosomal inheritance. It is more common, especially in certain European ethnic groups, and is seen frequently in Turks, North Africans, Arabs, Jews, and Armenians. In our country, the prevalence varies between 1/400 and 1/1000. In the pathogenesis, there is a mutation in the MEFV gene, composed of 10 exons and localized at the 16p13.3 chromosome. A 781 amino acid protein is encoded by (pyrine or marenostrin) the MEFV gene and regulates intranuclear peptide transcription when inflammation occurs. Clinically, FMF is characterized by pronounced acute phase response (leukocytosis, high erythrocyte sedimentation rate, C reactive protein, serum amyloid, fibrinogen) accompanied by recurrent fever and symptoms. Although the reasons that stimulate and terminate attacks are not known exactly, several factors such as infection, menstruation, surgical intervention, cold climatic conditions, a high-fat diet, and excessive physical activity can trigger attacks. In a small number of studies, it has been examined that the species that dominates the microbiota of individuals with FMF is also different from the microbiota patterns of healthy individuals. The purpose of this study is to evaluate some factors that affect the attacks’ frequency and duration in individuals with FMF, especially diet patterns.

Keywords

Familial Mediterranean fever, Nutrition, Diet

References

Tunca M, Ozdogan H. Molecular and genetic characteristics of hereditary autoinflammatory diseases. Curr Drug Targets Inflamm Allergy 2005; 4: 77-80.
The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997; 90 :797-807.
Tidow N, Chen X, Müller C, Kawano S, Gombart AF, Fischel-Ghodsian N, Koeffler HP. Hematopoieticspecific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin. Blood 2000; 95: 1451- 1455.
Portincasa P, Scaccianoce G, Palasciano G. Familial mediterranean fever: a fascinating model of inherited autoinflammatory disorder. Eur J Clin 2013; 43: 1314-1327.
Masters SL, Simon A, Aksentijevich I, Kastner DL. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). Annu Rev Immunol 2009; 27: 621-668.
Cebicci H, Aykac Cebicci M, Sahan M, Gurbuz S, Karaca B, Karakus A, Sutbeyaz ST, Sunkak S. Triggers for attacks in familial mediterranean fever: Are there any regional or ethnic differences? Acta Med Mediterr 2014; 30: 1349.
Karadag O, Tufan A, Yazisiz V, Ureten K, Yılmaz S, Cınar M, Akdogan A, Erdem H, Ozturk MA, Pay S, Dinc A. The factors considered as trigger for the attacks in patients with familial Mediterranean fever. Rheumatol Int 2013;33: 893-897.
Kastner DL, Aksentijevich I, Goldbach-Mansky R. Autoinflammatory disease reloaded: a clinical perspective. Cell 2010; 140: 784-790.
van der Hilst JCH, Simon A, Drenth JP. Hereditary periodic fever and reactive amyloidosis. Clin Exp Med 2005; 5: 87-98.
Portincasa P, Ruggiero V, Bonfrate L, Castorani L, Scaccianoce G, Piglionica D, Resta N, Wang D, Palasciano G. Impaired gastrointestinal motorfunction in patients with Familial Mediterranean fever:517. Eur J Clin 2012; 42: 87.
Turkish FMF Study Group. Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine 2005; 84(1): 1–11.
Cobankara V, Fidan G, Turk T, Zencir M, Colakoglu M, Ozen S. The prevalence of familial Mediterranean fever in the Turkish province of Denizli: a field study with a zero patient design. Clin Exp Rheumatol 2004; 22 (4 Suppl 34): 527–30.
Kisacik B, Yildirim B, Tasliyurt T, Ozyurt H, Ozyurt B, Yuce S, Kaya S, Ertenli I, Kiraz S. Increased frequency of familial Mediterranean fever in northern Turkey: a population-based study. Rheumatol Int 2009; 29(11): 1307-17.
Onen F, Sumer H, Turkay S, Akyurek O, Tunca M, Ozdogan H. Increased frequency of familial Mediterranean fever in Central Anatolia, Turkey. Clin Exp Rheumatol 2004; 22(4 Suppl 34): 31-4.
Drenth JP, van der Meer JW. Hereditary periodic fever. NEJM 2001; 345: 1748-1757.
Sahin Y, Kocamaz H, Ozen E. İki Bilinmeyenli Denklem Mi? Ailevi Akdeniz Ateşi ve Çölyak Hastalığı Nadir Birlikteliği. Sisli Etfal Hastan Tıp Bul 2017; 51 (3): 252-254.
Bas F, Kabatas-Eryilmaz S, Gunoz H, Darendeliler F, Aydin B, Bundak R. Type 1 diabetes mellitus associated with autoimmune thyroid disease, celiac disease and familial Mediterranean fever: case report. Turk J Pediatr Dis 2009; 51: 183-6.
Carroccio A, Mansueto P, Soresi M, Fayer F, Di Liberto D, Monguzzi E. Wheat Consumption Leads to Immune Activation and Symptom Worsening in Patients with Familial Mediterranean Fever: A Pilot Randomized Trial. Nutrients 2020; 12: 1127.
Tweezer-Zaks N, Doron-Libner A, Weiss P, Ben-Horin S, Barshack I, Lidar M, Livneh A. Familial Mediterranean fever and cryptogenic cirrhosis. Medicine 2007; 86(6): 355-362.
Yenokyan G, Armenian HK. Triggers for Attacks in Familial Mediterranean Fever: Application of the Case-Crossover Design. Am J Epidemiol 2012; 175(10): 1054–1061.
Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM., Tuohy KM, Teeling JL, Blaak EE, Fenech M, Vauzour D, McArdle HJ, Kremer BHA, Sterkman L, Vafeiadou K, Benedetti MM, Williams CM, Calder PC. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr 2015; 114: 999-1012.
Masson CJ, Mensink RP. Exchanging saturated fatty acids for (n-6) polyunsaturated fatty acids in a mixed meal may decrease postprandial lipemia and markers of inflammation and endothelial activity in overweight men. J Nutr 2011; 141: 816- 821.
Manning PJ, Sutherland WH, McGrath MM, de Jong SA, Walker RJ, Williams MJA. Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity (Silver Spring) 2008; 16: 2046-2052.
Kisla Ekinci RM, Balci S, Bisgin A, Cetin FT, Tumgor G. The contribution of diet preference to the disease course in children with familial Mediterranean fever: a cross-sectional study. Reumatologia 2020; 58 (2): 81–86.
Mellinkoff SM, Schwabe AD, Lawrence JS. A Dietary Treatment for Familial Mediterranean Fever. Arch Intern Med 1961; 108:80-5.
Sohar E, Gafni J, Chaimaw M, Prass M, Heller H. Low-fat diet in familial Mediterranean fever; a therapeutic trial. Arch Intern Med 1962; 110: 150-4.
Scrivo R, Perricone C, Altobelli A, Castellani C, Tinti L, Conti F, Valesini G. Dietary Habits Bursting Into the Complex Pathogenesis of Autoimmune Diseases: The Emerging Role of Salt from Experimental and Clinical Studies. Nutrients 2019; 11: 1013.
Wu H, Huang X, Qiu H, Zhao M, Liao W, Yuan S, Xie Y, Dai Y, Chang C, Yoshimura A, Lu Q. High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells. Sci Rep 2016; 6: 28065.
Barbaro NR, Foss JD, Kryshtal DO, Tsyba N, Kumaresan S, Xiao L, Mernaugh RL, Itani HA, Loperena R, Chen W, Dikalov S, Titze JM, Knollmann BC, Harrison DG, Kirabo A. Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension. Cell Rep 2017; 21: 1009-1020.
Verrecchia E, Sicignano LL, La Regina M, Nucera G, Patisso I, Cerrito L, Montalto M, Gasbarrini A, Manna R. Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever. Mediators Inflamm 2017; 2017: 1-6.
Onur H, Aral H, Arica V, Atalay Bercem G, Kasapcopur, O. Vitamin D levels in children with familial Mediterranean fever. Pediatr Rheumatol Online J 2016; 14: 28.
Lotfy HM, Marzouk H, Farag Y, Salah A, Taher H, Nabih M, Rashed L, El-Garf K. Serum vitamin D level in Egyptian children with Familial Mediterranean fever. Immunol. Lett 2017; 185: 74–78.
Kisla Ekinci RM, Balci S, Serbes M, Dogruel D, Altintas DU, Yilmaz M. Decreased serum vitamin B12 and vitamin D levels affect sleep quality in children with familial Mediterranean fever. Rheumatol Int 2018; 38: 83–87.
Gemici AI, Sevindik OG, Akar S, Tunca M. Vitamin B12 levels in familial Mediterranean fever patients treated with colchicine. Clin Exp Rheumatol 2013; 31 (77): 57-59.
Deschasaux M, Bouter KE, Prodan A, Levin E, Groen AK, Herrema H, Tremaroli V, Bakker GJ, Attaye I, Pinto-Sietsma SJ, van Raalte DH, Snijder MB, Nicolaou M, Peters R, Zwinderman AH, Bäckhed F, Nieuwdorp M. Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. Nat Med 2018; 24: 1526–31.
Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL. Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. PNAS 2003; 100: 13501–13506.
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 2001; 411: 599–603.
Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. Int J Biol Chem 2001; 276: 4812–4818.
Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 2001 411: 603–606.
Berkun Y, Karban A, Padeh S, Pras E, Shinar Y, Lidar M, Livneh A, Bujanoverve Y. NOD2/CARD15 gene mutations in patients with familial Mediterranean fever. Semin Arthritis Rheum 2012; 42: 84–88.
Khachatryan ZA, Ktsoyan ZA, Manukyan GP, Kelly D, Ghazaryan KA, Aminov RI. Predominant role of host genetics in controlling the composition of gut microbiota. PLoS ONE 2008; 3(8): e3064.
AA Amyloidosis Study Group. Specific changes in faecal microbiota are associated with familial Mediterranean fever. ARD 2019; 78: 1398–404.
Ktsoyan ZA, Beloborodova NV, Sedrakyan AM, Osipov GA, Khachatryan ZA, Kelly D, Manukyan GP, Arakelova KA, Hovhannisyan AI, Olenin AY, Arakelyan AA, Ghazaryan KA, Aminov RI. Profiles of Microbial Fatty Acids in the Human Metabolome are Disease-Specific. Front Microbiol 2010; 1: 148.
Ktsoyan ZA, Mkrtchyan MS, Zakharyan MK, Mnatsakanyan AA, Arakelova KA, Gevorgyan ZU, Sedrakyan AM, Hovhannisyan AI, Arakelyan AA, Aminov RI. Systemic Concentrations of Short Chain Fatty Acids Are Elevated in Salmonellosis and Exacerbation of Familial Mediterranean Fever. Front. Microbiol 2016; 7: 776.
Pepoyan AZ, Balayan MH, Manvelyan AM, Mamikonyan V, Isajanyan M, Tsaturyan VV, Kamiya S, Netrebov V, Cikindas ML. Lactobacillus acidophilus INMIA 9602 Er-2 strain 317/402 probiotic regulates growth of commensal Escherichia coli in gut microbiota of familial Mediterranean fever disease subjects. Lett Appl Microbiol 2017; 64: 254–260.
Di Ciaula A, Stella A, Bonfrate L, Wang DQH, Portincasa P. Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF). Genes 2020; 11: 1041.

Ailesel Akdeniz Ateşinde Diyet ve Mikrobiyotanın Ataklar Üzerindeki Etkileri

Year 2023, Volume: 9 Issue: 2, 206 - 212, 01.05.2023

M. Gizem Keser Nurhan Unusan

https://doi.org/10.53394/akd.1010790

Abstract

Ailesel Akdeniz ateşi otozomal geçişli ve en sık görülen otoinflamatuar hastalıklardan birisidir. Özellikle Avrupa kökenli bazı etnik gruplarda daha yaygındır. Türkler, Kuzey Afrikalılar, Araplar, Yahudiler ve Ermenilerde sıklıkla görülmektedir. Ülkemiz de ise prevalansı 1/400 ve 1/1000 arasında değişmektedir. Patogenezinde 16p13.3. kromozomda lokalize olan 10 ekzondan oluşan MEFV genindeki mutasyon etkilidir. MEFV geni 781 amino asitlik bir proteini (pirin veya marenostrin) kodlamaktadır ve inflamasyon durumunda intranükleer peptidlerin transkripsiyonunu düzenlemektedir. Klinik olarak Ailesel Akdeniz ateşi, tekrarlayan ateş ve semptomların eşlik ettiği belirgin akut faz yanıtı (lökositoz, yüksek eritrosit sedimantasyon hızı, fibrinojen, C reaktif protein, serum amiloid) ile karakterizedir. Atakları uyaran ve sonlandıran nedenler tam olarak bilinmemekle birlikte enfeksiyon, menstrüasyon, cerrahi girişim gibi çeşitli faktörlerin, soğuk iklim koşulları, yüksek yağlı diyet ve fazla fiziksel aktivitenin atakları tetikleyebileceği bilinmektedir. Yürütülen az sayıdaki çalışmada Ailesel Akdeniz ateşi hastalığına sahip bireylerin mikrobiyotasında hakim olan türün de sağlıklı bireylerin mikrobiyota örüntülerinden farklı olduğu gözlenmiştir. Bu çalışmanın amacı Ailesel Akdeniz ateşi hastalığına sahip bireylerin atak sıklık ve sürelerine etki eden başta diyet örüntüsü dahil olmak üzere bazı faktörleri incelenmeyi amaçlamaktadır.

Keywords

Ailesel Akdeniz Ateşi, Beslenme, Diyet

References

Tunca M, Ozdogan H. Molecular and genetic characteristics of hereditary autoinflammatory diseases. Curr Drug Targets Inflamm Allergy 2005; 4: 77-80.
The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997; 90 :797-807.
Tidow N, Chen X, Müller C, Kawano S, Gombart AF, Fischel-Ghodsian N, Koeffler HP. Hematopoieticspecific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin. Blood 2000; 95: 1451- 1455.
Portincasa P, Scaccianoce G, Palasciano G. Familial mediterranean fever: a fascinating model of inherited autoinflammatory disorder. Eur J Clin 2013; 43: 1314-1327.
Masters SL, Simon A, Aksentijevich I, Kastner DL. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). Annu Rev Immunol 2009; 27: 621-668.
Cebicci H, Aykac Cebicci M, Sahan M, Gurbuz S, Karaca B, Karakus A, Sutbeyaz ST, Sunkak S. Triggers for attacks in familial mediterranean fever: Are there any regional or ethnic differences? Acta Med Mediterr 2014; 30: 1349.
Karadag O, Tufan A, Yazisiz V, Ureten K, Yılmaz S, Cınar M, Akdogan A, Erdem H, Ozturk MA, Pay S, Dinc A. The factors considered as trigger for the attacks in patients with familial Mediterranean fever. Rheumatol Int 2013;33: 893-897.
Kastner DL, Aksentijevich I, Goldbach-Mansky R. Autoinflammatory disease reloaded: a clinical perspective. Cell 2010; 140: 784-790.
van der Hilst JCH, Simon A, Drenth JP. Hereditary periodic fever and reactive amyloidosis. Clin Exp Med 2005; 5: 87-98.
Portincasa P, Ruggiero V, Bonfrate L, Castorani L, Scaccianoce G, Piglionica D, Resta N, Wang D, Palasciano G. Impaired gastrointestinal motorfunction in patients with Familial Mediterranean fever:517. Eur J Clin 2012; 42: 87.
Turkish FMF Study Group. Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine 2005; 84(1): 1–11.
Cobankara V, Fidan G, Turk T, Zencir M, Colakoglu M, Ozen S. The prevalence of familial Mediterranean fever in the Turkish province of Denizli: a field study with a zero patient design. Clin Exp Rheumatol 2004; 22 (4 Suppl 34): 527–30.
Kisacik B, Yildirim B, Tasliyurt T, Ozyurt H, Ozyurt B, Yuce S, Kaya S, Ertenli I, Kiraz S. Increased frequency of familial Mediterranean fever in northern Turkey: a population-based study. Rheumatol Int 2009; 29(11): 1307-17.
Onen F, Sumer H, Turkay S, Akyurek O, Tunca M, Ozdogan H. Increased frequency of familial Mediterranean fever in Central Anatolia, Turkey. Clin Exp Rheumatol 2004; 22(4 Suppl 34): 31-4.
Drenth JP, van der Meer JW. Hereditary periodic fever. NEJM 2001; 345: 1748-1757.
Sahin Y, Kocamaz H, Ozen E. İki Bilinmeyenli Denklem Mi? Ailevi Akdeniz Ateşi ve Çölyak Hastalığı Nadir Birlikteliği. Sisli Etfal Hastan Tıp Bul 2017; 51 (3): 252-254.
Bas F, Kabatas-Eryilmaz S, Gunoz H, Darendeliler F, Aydin B, Bundak R. Type 1 diabetes mellitus associated with autoimmune thyroid disease, celiac disease and familial Mediterranean fever: case report. Turk J Pediatr Dis 2009; 51: 183-6.
Carroccio A, Mansueto P, Soresi M, Fayer F, Di Liberto D, Monguzzi E. Wheat Consumption Leads to Immune Activation and Symptom Worsening in Patients with Familial Mediterranean Fever: A Pilot Randomized Trial. Nutrients 2020; 12: 1127.
Tweezer-Zaks N, Doron-Libner A, Weiss P, Ben-Horin S, Barshack I, Lidar M, Livneh A. Familial Mediterranean fever and cryptogenic cirrhosis. Medicine 2007; 86(6): 355-362.
Yenokyan G, Armenian HK. Triggers for Attacks in Familial Mediterranean Fever: Application of the Case-Crossover Design. Am J Epidemiol 2012; 175(10): 1054–1061.
Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM., Tuohy KM, Teeling JL, Blaak EE, Fenech M, Vauzour D, McArdle HJ, Kremer BHA, Sterkman L, Vafeiadou K, Benedetti MM, Williams CM, Calder PC. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr 2015; 114: 999-1012.
Masson CJ, Mensink RP. Exchanging saturated fatty acids for (n-6) polyunsaturated fatty acids in a mixed meal may decrease postprandial lipemia and markers of inflammation and endothelial activity in overweight men. J Nutr 2011; 141: 816- 821.
Manning PJ, Sutherland WH, McGrath MM, de Jong SA, Walker RJ, Williams MJA. Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity (Silver Spring) 2008; 16: 2046-2052.
Kisla Ekinci RM, Balci S, Bisgin A, Cetin FT, Tumgor G. The contribution of diet preference to the disease course in children with familial Mediterranean fever: a cross-sectional study. Reumatologia 2020; 58 (2): 81–86.
Mellinkoff SM, Schwabe AD, Lawrence JS. A Dietary Treatment for Familial Mediterranean Fever. Arch Intern Med 1961; 108:80-5.
Sohar E, Gafni J, Chaimaw M, Prass M, Heller H. Low-fat diet in familial Mediterranean fever; a therapeutic trial. Arch Intern Med 1962; 110: 150-4.
Scrivo R, Perricone C, Altobelli A, Castellani C, Tinti L, Conti F, Valesini G. Dietary Habits Bursting Into the Complex Pathogenesis of Autoimmune Diseases: The Emerging Role of Salt from Experimental and Clinical Studies. Nutrients 2019; 11: 1013.
Wu H, Huang X, Qiu H, Zhao M, Liao W, Yuan S, Xie Y, Dai Y, Chang C, Yoshimura A, Lu Q. High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells. Sci Rep 2016; 6: 28065.
Barbaro NR, Foss JD, Kryshtal DO, Tsyba N, Kumaresan S, Xiao L, Mernaugh RL, Itani HA, Loperena R, Chen W, Dikalov S, Titze JM, Knollmann BC, Harrison DG, Kirabo A. Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension. Cell Rep 2017; 21: 1009-1020.
Verrecchia E, Sicignano LL, La Regina M, Nucera G, Patisso I, Cerrito L, Montalto M, Gasbarrini A, Manna R. Small Intestinal Bacterial Overgrowth Affects the Responsiveness to Colchicine in Familial Mediterranean Fever. Mediators Inflamm 2017; 2017: 1-6.
Onur H, Aral H, Arica V, Atalay Bercem G, Kasapcopur, O. Vitamin D levels in children with familial Mediterranean fever. Pediatr Rheumatol Online J 2016; 14: 28.
Lotfy HM, Marzouk H, Farag Y, Salah A, Taher H, Nabih M, Rashed L, El-Garf K. Serum vitamin D level in Egyptian children with Familial Mediterranean fever. Immunol. Lett 2017; 185: 74–78.
Kisla Ekinci RM, Balci S, Serbes M, Dogruel D, Altintas DU, Yilmaz M. Decreased serum vitamin B12 and vitamin D levels affect sleep quality in children with familial Mediterranean fever. Rheumatol Int 2018; 38: 83–87.
Gemici AI, Sevindik OG, Akar S, Tunca M. Vitamin B12 levels in familial Mediterranean fever patients treated with colchicine. Clin Exp Rheumatol 2013; 31 (77): 57-59.
Deschasaux M, Bouter KE, Prodan A, Levin E, Groen AK, Herrema H, Tremaroli V, Bakker GJ, Attaye I, Pinto-Sietsma SJ, van Raalte DH, Snijder MB, Nicolaou M, Peters R, Zwinderman AH, Bäckhed F, Nieuwdorp M. Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. Nat Med 2018; 24: 1526–31.
Shoham NG, Centola M, Mansfield E, Hull KM, Wood G, Wise CA, Kastner DL. Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. PNAS 2003; 100: 13501–13506.
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 2001; 411: 599–603.
Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. Int J Biol Chem 2001; 276: 4812–4818.
Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 2001 411: 603–606.
Berkun Y, Karban A, Padeh S, Pras E, Shinar Y, Lidar M, Livneh A, Bujanoverve Y. NOD2/CARD15 gene mutations in patients with familial Mediterranean fever. Semin Arthritis Rheum 2012; 42: 84–88.
Khachatryan ZA, Ktsoyan ZA, Manukyan GP, Kelly D, Ghazaryan KA, Aminov RI. Predominant role of host genetics in controlling the composition of gut microbiota. PLoS ONE 2008; 3(8): e3064.
AA Amyloidosis Study Group. Specific changes in faecal microbiota are associated with familial Mediterranean fever. ARD 2019; 78: 1398–404.
Ktsoyan ZA, Beloborodova NV, Sedrakyan AM, Osipov GA, Khachatryan ZA, Kelly D, Manukyan GP, Arakelova KA, Hovhannisyan AI, Olenin AY, Arakelyan AA, Ghazaryan KA, Aminov RI. Profiles of Microbial Fatty Acids in the Human Metabolome are Disease-Specific. Front Microbiol 2010; 1: 148.
Ktsoyan ZA, Mkrtchyan MS, Zakharyan MK, Mnatsakanyan AA, Arakelova KA, Gevorgyan ZU, Sedrakyan AM, Hovhannisyan AI, Arakelyan AA, Aminov RI. Systemic Concentrations of Short Chain Fatty Acids Are Elevated in Salmonellosis and Exacerbation of Familial Mediterranean Fever. Front. Microbiol 2016; 7: 776.
Pepoyan AZ, Balayan MH, Manvelyan AM, Mamikonyan V, Isajanyan M, Tsaturyan VV, Kamiya S, Netrebov V, Cikindas ML. Lactobacillus acidophilus INMIA 9602 Er-2 strain 317/402 probiotic regulates growth of commensal Escherichia coli in gut microbiota of familial Mediterranean fever disease subjects. Lett Appl Microbiol 2017; 64: 254–260.
Di Ciaula A, Stella A, Bonfrate L, Wang DQH, Portincasa P. Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF). Genes 2020; 11: 1041.

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Details

Primary Language	English
Subjects	Clinical Sciences
Journal Section	Reviews
Authors	M. Gizem Keser 0000-0001-9425-9088 Nurhan Unusan 0000-0002-7445-6903
Early Pub Date	April 28, 2023
Publication Date	May 1, 2023
Submission Date	October 19, 2021
Published in Issue	Year 2023 Volume: 9 Issue: 2

Cite

APA	Keser, M. G., & Unusan, N. (2023). The Effects of Diet and Microbiota on Attacks in Familial Mediterranean Fever. Akdeniz Tıp Dergisi, 9(2), 206-212. https://doi.org/10.53394/akd.1010790

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