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Doppler Ultrasonography Assessment of Uterine Artery Blood Flow Throughout Late Pregnancy in Awassi Ewes

Year 2023, Volume: 12 Issue: 2, 42 - 49, 26.12.2023
https://doi.org/10.53913/aduveterinary.1326273

Abstract

Monitoring uterine blood flow during pregnancy provides information about fetal development. The aim of this study was to determine changes in uterine artery blood flow in the second half of pregnancy in Awassi sheep. The study included a total of 20 sheep with a single pregnancy, separated into 4 groups according to the period of the pregnancy, as 90-105-120-135 days. By monitoring the uterine artery blood flow with Doppler ultrasound, measurements were taken of the pulsatilite index (PI), resistance index (RI), end diastolic velocity (EDV), peak systolic velocity (PSV), systolic/diastolic ratio (S/D), and time-averaged peak (TAP). The data obtained were analyzed with repeated measures ANOVA (variance analysis). Throughout the pregnancy periods, a time-related significant difference was seen between the groups in respect of the PSV, EDV, TAP, PI, RI, and S/D values (p<0.01). The PSV, EDV, and TAP values were observed to be significantly higher on the 135th day of the pregnancy compared to the 90th, 105th, and 120th days (p<0.05). The PI value was seen to be significantly lower on the 135th day compared to the 90th and 105th days (p<0.05). The RI value was seen to be significantly lower on the 135th day compared to the 105th, and 120th days (p<0.05). The S/D value was seen to be significantly higher on the 135th day compared to the 120th day (p<0.05). Statistically significantly differences were observed in the changes in the uterine artery blood flow in the second half of the pregnancy of Awassi sheep. It was concluded that as the vast majority of fetal development occurs in the second half of the pregnancy, determination of changes in Doppler ultrasound parameters would be useful for the earlier diagnosis of risks that could be life-threatening to both the ewe and lamb.

References

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  • Batista, P.R., Gobello, C., Rube, A., Barrena, J.P., Re, N.E., & Blanco, P.G. (2018). Reference range of gestational uterine artery resistance index in small canine breeds. Theriogenology, 114, 81-84. https:// doi.org/10.1016/j.theriogenology.2018.03.015
  • Beltrame, R.T., Covre, C., Littig, L.B., de Barros Martins, A., Quirino, C.R., Junior, A.B., & da Costa, R.L.D. (2017). Transrectal Doppler sonography of uterine blood flow in ewes during pregnancy. Theriogenology, 91, theriogenology.2016.12.026 55-61.https://doi.org/10.1016/j.
  • Blanco, P.G., Rodríguez, R., Olguín, S., Rube, A., Tórtora, M., & Gobello, C. (2014). Doppler ultrasonographic assessment of maternal and fetal arteries during normal feline gestation. Animal Reproduction Science, 146(1-2), 63-69. https://doi.org/10.1016/j. anireprosci.2014.02.003
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  • Elmetwally, M., Rohn, K., & Meinecke-Tillmann, S. (2016). Noninvasive color Doppler sonography of uterine blood flow throughout pregnancy in sheep and goats. Theriogenology, 85(6), 1070-1079. https://doi.org/10.1016/j.theriogenology.2015.11.018
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  • Hafez, S.A., Borowicz,P., Reynolds, L.P., & Redmer, D.A. (2010). Maternal and fetal microvasculature in sheep placenta at several stages of gestation. Journal of Anatomy, 216(3), 292-300. https:// doi.org/10.1111/j.1469-7580.2009.01184.x
  • Hassan, M., Arshad, U., Erdoğan, G., & Ahmad, N. (2020). Evaluation of haemodynamic changes of uterine arteries using Doppler ultrasonography during different stages of pregnancy in Bos indicus cows. Reproduction in Domestic Animals, 55(10), 1425-1433. https://doi.org/10.1111/rda.13793
  • Herzog, K., & Bollwein, H. (2007). Application of Doppler ultrasonography in cattle reproduction. Reproduction in Domestic Animals, 42, 5158. https://doi.org/10.1111/ j.1439-0531.2007.00903.x.
  • Kim-Egloff, C., Hässig, M., Bruckmaier, R., & Bleul, U. (2016). Doppler sonographic examination of uterine and placental perfusion in cows in the last month of gestation and effects of epidural anesthesia and isoxsuprine. Theriogenology, 85(5), 986-998. https://doi. org/10.1016/j.theriogenology.2015.11.010
  • Lemos, S.G., Campos, D.G., Ferreira, C.S., Balaro, M.F., Cunha, L.E., Pinna, A.E., & Brandão, F.Z. (2017). Uterine vasculature of pregnant mares of donkey and stallion through the Doppler ultrasonography spectral mode. Pesquisa Veterinária Brasileira, 37(8), 877-882. https://doi.org/10.1590/S0100-736X2017000800017.
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  • Panarace, M., Garnil, C., Marfil, M., Jauregui, G., Lagioia, J., Luther, E., & Medina, M. (2006). Transrectal Doppler sonography for evaluation of uterine blood flow throughout pregnancy in 13 cows. Theriogenology, 66(9), 2113-2119. https://doi.org/10.1016/ j.theriogenology.2006.03.040.
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Year 2023, Volume: 12 Issue: 2, 42 - 49, 26.12.2023
https://doi.org/10.53913/aduveterinary.1326273

Abstract

References

  • Abdelhalim, E.M., Kishk, E.A.F., Atwa, K.A., & Metawea, M.A.H. (2014). Validity of umbilical artery Doppler waveform versus umbilical vein Doppler waveform in the prediction of neonatal outcome in intrauterine growth restriction cases. Middle East Fertility Society Journal, 19(4), 281-286. https://doi.org/10.1016/j. mefs.2013.09.005
  • Abdelnaby, E.A., Emam, I.A., El-Sherbiny, H.R., & Fadl, A.M. (2022). The effects of aging and gestational month on uteroplacental vascular perfusion, and umbilical artery hemodynamics in pregnant jennies. BMC Veterinary Research, 18(1), 1-9. https://doi.org/10.1186/ s12917-022-03499-8
  • Akkuş, T., & Erdoğan, G. (2019). Ultrasonographic evaluation of feto-placental tissues at different intrauterine locations in rabbit. Theriogenology, 138, 16-23. https://doi.org/10.1016/j. theriogenology.2019.06.042
  • Batista, P.R., Gobello, C., Rube, A., Barrena, J.P., Re, N.E., & Blanco, P.G. (2018). Reference range of gestational uterine artery resistance index in small canine breeds. Theriogenology, 114, 81-84. https:// doi.org/10.1016/j.theriogenology.2018.03.015
  • Beltrame, R.T., Covre, C., Littig, L.B., de Barros Martins, A., Quirino, C.R., Junior, A.B., & da Costa, R.L.D. (2017). Transrectal Doppler sonography of uterine blood flow in ewes during pregnancy. Theriogenology, 91, theriogenology.2016.12.026 55-61.https://doi.org/10.1016/j.
  • Blanco, P.G., Rodríguez, R., Olguín, S., Rube, A., Tórtora, M., & Gobello, C. (2014). Doppler ultrasonographic assessment of maternal and fetal arteries during normal feline gestation. Animal Reproduction Science, 146(1-2), 63-69. https://doi.org/10.1016/j. anireprosci.2014.02.003
  • Blanco, P.G., Rodríguez, R., Rube, A., Arias, D.O., Tórtora, M., Díaz, J.D., & Gobello, C. (2011). Doppler ultrasonographic assessment of maternal and fetal blood flow in abnormal canine pregnancy. Animal Reproduction Science, 126(1-2), 130-135. https://doi. org/10.1016/j.anireprosci.2011.04.016
  • Blanco, P.G., Vercellini, R., Rube, A., Rodríguez, R., Arias, D.O., & Gobello, C. (2016). Evaluation of feline uterine and umbilical arteries blood f low in a pharmacologically induced abnormal gestation model. Theriogenology, 86(9), 2323-2327. https://doi.org/10.1016/j. theriogenology.2016.07.028
  • Bollwein, H., Baumgartner, U., & Stolla, R. (2002). Transrectal Doppler sonography of uterine blood flow in ows during pregnancy. Theriogenology, 57(8), 2053-2061. https://doi.org/10.1016/S0093691X(02)00706-9
  • Bollwein, H., Maierl, J., Mayer, R., & Stolla, R. (1998). Transrectal color Doppler sonography of the A. uterina in cyclic mares. Theriogenology, 49(8), 1483-1488. https://doi.org/10.1016/S0093691X(98)00094-6
  • Bollwein, H., Mayer, R., & Stolla, R. (2003). Transrectal Doppler sonography of uterine blood flow during early pregnancy in mares. Theriogenology, 60(4), 597-605. https://doi.org/10.1016/S0093691X(03)00080-3
  • Bollwein, H., Weber, F., Woschée, I., & Stolla, R. (2004). Transrectal Doppler sonography of uterine and umbilical blood flow during pregnancy in mares. Theriogenology, 61(2-3), 499-509. https://doi. org/10.1016/S0093-691X(03)00225-5
  • Brito, A.B., Miranda, S.A., Ruas, M.R., Santos, R.R., & Domingues, S.F.S. (2010). Assessment of feline fetal viability by conceptus echobiometry and triplex Doppler ultrasonography of uterine and umbilical arteries. Animal Reproduction Science, 122, 276-281. https://doi.org/10.1016/j.anireprosci.2010.09.003
  • Dickey, R.P. (1997). Doppler ultrasound investigation of uterine and ovarian blood flow in infertility and early pregnancy. Human Reproduction Update, 3(5), 467-503. https://doi.org/10.1093/ humupd/3.5.467.
  • Dubiel, M., Bręborowicz, G.H., & Gudmundsson, S. (2003). Evaluation of fetal circulation redistribution in pregnancies with absent or reversed diastolic flow in the umbilical artery. Early Human Development, 71(2), 149-156. https://doi.org/10.1016/S03783782(03)00006-9
  • Elmetwally, M. (2016). Uterine blood flow indices in sheep during pregnancy. Quality in Primary Care, 24(4), 197-202.
  • Elmetwally, M., Rohn, K., & Meinecke-Tillmann, S. (2016). Noninvasive color Doppler sonography of uterine blood flow throughout pregnancy in sheep and goats. Theriogenology, 85(6), 1070-1079. https://doi.org/10.1016/j.theriogenology.2015.11.018
  • Ferrell, C.L. (1991). Maternal and fetal influences on uterine and conceptus development in the cow: I. Growth of tissues of the gravid uterus. Journal of Animal Science, 69(5), 1945-1953. https:// doi.org/10.2527/1991.6951945x
  • Fleischer, A.C., Goldstein, R.B., Bruner, J.P., & Worrell, J.A. (1994). Doppler sonography in obstetrics and gynecology. In Fleischer, A.C., Goldstein, R.B., Bruner, J.P., & Worrell, J.A. (Eds). Ultrasonography in Obstetrics and Gynecology, 3rd ed. Philadelphia: WB Saunders, 503-523.
  • Fowden, A.L., Ward, J.W., Wooding, F.P.B., Forhead, A.J., & Constancia, M. (2006). Programming placental nutrient transport capacity. The Journal of Physiology, 572(1), 5-15. https://doi.org/10.1113/ jphysiol.2005.104141
  • Ginther, O.J., & Utt, M.D. (2004). Doppler ultrasound in equine reproduction: principles, techniques, and potential. Journal of Equine Veterinary Science, 24(12), 516-526. https://doi. org10.1016/j. jevs.2004.11.005
  • Gomez, O., Figueras, F., Martinez, J.M., Del Rio, M., Palacio, M., Eixarch, E., Coll, O., Cararach, V., & Vanrell, J.A. (2006). Sequential changes in uterine artery blood flow pattern between the first and second trimesters of gestation in relation to pregnancy outcome. Ultrasound in Obstetrics and Gynecology: The Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, 28(6), 802-808. https://doi.org/10.1002/uog.2814
  • Gudmundsson, S., & Maršál, K. (1991). Blood velocity waveforms in the fetal aorta and umbilical artery as predictors of fetal outcome: a comparison. American Journal of Perinatology, 8(01), 1-6. 10.1055/ s-2007-999326
  • Gupta, U., Qureshi, A., & Samal, S. (2009). Doppler velocimetry in normal and hypertensive pregnancy. International Journal of Gynecology & Obstetrics, 11(2), 1-6.
  • Hafez, S.A., Borowicz,P., Reynolds, L.P., & Redmer, D.A. (2010). Maternal and fetal microvasculature in sheep placenta at several stages of gestation. Journal of Anatomy, 216(3), 292-300. https:// doi.org/10.1111/j.1469-7580.2009.01184.x
  • Hassan, M., Arshad, U., Erdoğan, G., & Ahmad, N. (2020). Evaluation of haemodynamic changes of uterine arteries using Doppler ultrasonography during different stages of pregnancy in Bos indicus cows. Reproduction in Domestic Animals, 55(10), 1425-1433. https://doi.org/10.1111/rda.13793
  • Herzog, K., & Bollwein, H. (2007). Application of Doppler ultrasonography in cattle reproduction. Reproduction in Domestic Animals, 42, 5158. https://doi.org/10.1111/ j.1439-0531.2007.00903.x.
  • Kim-Egloff, C., Hässig, M., Bruckmaier, R., & Bleul, U. (2016). Doppler sonographic examination of uterine and placental perfusion in cows in the last month of gestation and effects of epidural anesthesia and isoxsuprine. Theriogenology, 85(5), 986-998. https://doi. org/10.1016/j.theriogenology.2015.11.010
  • Lemos, S.G., Campos, D.G., Ferreira, C.S., Balaro, M.F., Cunha, L.E., Pinna, A.E., & Brandão, F.Z. (2017). Uterine vasculature of pregnant mares of donkey and stallion through the Doppler ultrasonography spectral mode. Pesquisa Veterinária Brasileira, 37(8), 877-882. https://doi.org/10.1590/S0100-736X2017000800017.
  • Meschia, organs. G. (2011).Circulation to female reproductive Comprehensive Physiology, 241-269. https://doi. org/10.1002/cphy.cp020308
  • Miranda, S.A., & Domingues, S.F.S. (2010). Conceptus ecobiometry and triplex Doppler ultrasonography of uterine and umbilical arteries for assessment of fetal viability in dogs. Theriogenology, 74(4), 608 617. https://doi.org/10.1016/j.theriogenology.2010.03.008
  • Molina-Font, J.A. (1998). Nutrition and fetal growth. Early Human Development, 53, 3782(98)00065-6 51-60. https://doi.org/10.1016/S0378
  • Mu, J., & Adamson, S.L. (2006). Developmental changes in hemodynamics of uterine artery, utero-and umbilicoplacental, and vitelline circulations in mouse throughout gestation. American Journal of Physiology-Heart and Circulatory Physiology, 291(3), 1421-1428. https://doi.org/10.1152/ajpheart.00031.2006
  • Nautrup, C.P. (1998). Doppler ultrasonography of canine maternal and fetal arteries during normal gestation. Reproduction, 112(2), 301 314. https://doi.org/10.1530/jrf.1120301
  • Nicolaides, K., Rizzo, G., Hecker, K., & Ximenes, R. (2000). Methodology of Doppler assessment of the placental and fetal circulations: Uteroplacental circulation in Doppler in obstetrics. ISUOG. Fetal Medicine Foundation, 137, 32-61.
  • Owen, P., & Ogston, S. (1997). Standards for the quantification of serial changes in Doppler resistance indices from the umbilical arteries. Early Human Development, 49(1), 39-47. https://doi. org/10.1016/S0378-3782(97)01873-2
  • Özkaya, Ü., Özkan, S., Özeren, S., & Çorakçı, A. (2007). Doppler examination of uteroplacental circulation in early pregnancy: can it predict adverse outcome? Journal of Clinical Ultrasound, 35(7), 382-386. https://doi.org/10.1002/jcu.20370
  • Panarace, M., Garnil, C., Marfil, M., Jauregui, G., Lagioia, J., Luther, E., & Medina, M. (2006). Transrectal Doppler sonography for evaluation of uterine blood flow throughout pregnancy in 13 cows. Theriogenology, 66(9), 2113-2119. https://doi.org/10.1016/ j.theriogenology.2006.03.040.
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There are 51 citations in total.

Details

Primary Language English
Subjects Animal Reproduction and Breeding
Journal Section Research Articles
Authors

Tuğra Akkuş 0000-0002-6002-5942

Birten Emre 0000-0001-8785-417X

Ömer Yaprakcı 0000-0002-7784-9438

Publication Date December 26, 2023
Submission Date July 12, 2023
Published in Issue Year 2023 Volume: 12 Issue: 2

Cite

APA Akkuş, T., Emre, B., & Yaprakcı, Ö. (2023). Doppler Ultrasonography Assessment of Uterine Artery Blood Flow Throughout Late Pregnancy in Awassi Ewes. Animal Health Production and Hygiene, 12(2), 42-49. https://doi.org/10.53913/aduveterinary.1326273