Research Article
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The Investigation Protective Effect of Tarantula Cubensis Extract in Rats Induced Experimental Gentamicin Nephrotoxicity

Year 2023, Volume: 12 Issue: 1, 31 - 39, 23.06.2023
https://doi.org/10.53913/aduveterinary.1263745

Abstract

Gentamicin (GM), which is used in the treatment of infections caused by gram-negative bacteria, has limited clinical use due to its serious nephrotoxic side effects. Tarantula cubensis extract (TCE) is a homeopathic product that is widely used and proven to be effective in veterinary medicine to benefit from its regeneration, demarcation, antiphlogistic and resorptive effects. The aim of the study was to investigate the possible protective effects of TCE against these negative effects of Gentamicin, which is one of the drugs that trigger the formation of free radicals in the body, in terms of oxidative stress, apoptosis and antioxidant parameters. In this study, rats were divided into four equal groups. Groups; Control, GM, TCE, GM+TCE. Blood and kidney tissue samples were taken 24 hours after the last injection. Urea and creatinine analysis were performed in serum, MDA, SOD and TAS analysis were performed in kidney and serum samples. Bcl-2 and Bax analyzes and histopathological evaluations were performed in the kidney tissue. An increase in MDA, creatinine and urea levels, and a decrease in TAS and SOD levels were observed in the GM group compared to the control group. On the other hand, in the GM+TCE group, a decrease was observed in increasing parameters compared to the GM group, and an increase in TAS and SOD levels was observed. In the histopathological and immunohistochemical examination of kidney tissue, it was determined that pathological disorders and increased apoptosis (decrease in Bcl-2, increase in Bax) in the GM group decreased with TCE application. In conclusion, in the light of the data in this study, we believe that high-dose gentamicin causes side effects in the kidneys, while TCE may have antioxidant, antiapoptotic, protective and curative effects. However, additional studies are needed to confirm this assumption.

Supporting Institution

Scientific Research Projects Unit of Balikesir University, Turkey,

Project Number

2019/10

Thanks

Special thanks also to Assoc. Prof. Dr. Hasan Aksit (Department of Biochemistry, Faculty of Veterinary Medicine, Balikesir University), Assoc. Prof. Dr. Eren Altun (Department of Pathology, Bagcilar Training and Research Hospital, University of Health Sciences) who helped during the interpretation of biochemical, immunohistochemical and histopathological analyzes.

References

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  • Aldahmash, B.A., El-Nagar, D.M., & Ibrahim, K.E. (2016). Reno-protective effects of propolis on gentamicin-induced acute renal toxicity in swiss albino mice. Nefrologia, 36(6), 643-652. 10.1016/j.nefro.2016.06.004
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  • Lotfollahzadeh, S., Alizadeh, M.R., Mohri, M., & Mokhber-Dezfouli, M.R. (2012). The therapeutic effect of Tarantula cubensis Extract (Theranekron(R)) in foot and mouth disease in cattle: a randomised trial in an endemic setting. Homeopathy, 101(3), 159-164. 10.1016/j.homp.2012.05.008
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., & Randall, R.J. (1951). Protein Measurement with folin phenol reagent. Journal of Biological Chemistry, 193, 265-75.
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  • Nadeem R.I., Aboutaleb A.S., Younis N.S., Ahmed H.I. (2023) Diosmin Mitigates Gentamicin-Induced Nephrotoxicity in Rats: Insights on miR-21 and -155 Expression, Nrf2/HO-1 and p38-MAPK/NF-κB Pathways. Toxics, 11, 48. 10.3390/toxics11010048
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  • Ozsayin, G.H. (2019). Gentamisin ile sıçanlarda oluşturulan nefrotoksisite üzerinde Cyclotrichium niveum ekstresinin koruyucu etkisi. [Master dissertation University of Cukurova]. https://acikbilim.yok.gov.tr/handle/20.500.12812/123637.
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  • Rizwana, K., Mohammad, A., Shah, C.S., Fahamiya, N. & Shiffa, M. (2022). Nephroprotective activity of the hydro-alcoholic, ethanolic extract and its fractions of tukhme soya (Anethum sowa Roxb.) against gentamicin induced nephrotoxicity in albino rats. Journal of Young Pharmacists, 14(1), 50-55. 10.5530/jyp.2022.14.10
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Year 2023, Volume: 12 Issue: 1, 31 - 39, 23.06.2023
https://doi.org/10.53913/aduveterinary.1263745

Abstract

Project Number

2019/10

References

  • Abdelzaher, W.Y., El-Tahawy, N.F. G., Ali A.H.S.A.B., Mohamed H.A., Welson N.N. & Labib D.A. A. (2023) Rivastigmine ameliorates gentamicin experimentally induced acute renal toxicity. International Immunopharmacology, 114, 109492. 10.1016/j.intimp.2022.109492
  • Agena, R., Cortes-Sanchez, A.J., Hernandez-Sanchez, H. & Jaramillo-Flores M.E. (2023) Pro-apoptotic activity of bioactive compounds from seaweeds: promising sources for developing novel anticancer drugs. Marine Drugs, 21(3), 182, 10.3390/md21030182
  • Akbari, B., Baghaei-Yazdi, N., Bahmaie, M. & Abhari F.M. (2022) The role of plant-derived natural antioxidants in reduction of oxidative stress. BioFactors, 48, 611-633. 10.1002/biof.1831
  • Aksit, H., & Bildik, A. (2008). Apoptosis. Van Veterinary Journal, 19(1), 55-63.
  • Aldahmash, B.A., El-Nagar, D.M., & Ibrahim, K.E. (2016). Reno-protective effects of propolis on gentamicin-induced acute renal toxicity in swiss albino mice. Nefrologia, 36(6), 643-652. 10.1016/j.nefro.2016.06.004
  • Bai, R., Fan J., Wang Y., Wang Y., Li X., & Hu F. (2023) Protective effect of Cistanche deserticola on gentamicin-induced nephrotoxicity in rats. Chinese Herbal Medicines, 15 (1), 102-109. 10.1016/j.chmed.2022.03.008
  • Basar, G. (2014). Homeopati: Doğal, yan etkisiz ve bütünsel bir tedavi yöntemi. Turkiye Klinikleri Family Medicine - Special Topics, 5(4), 41-45.
  • Bratton, S.B., MacFarlane, M., Cain, K., & Cohen, G.M. (2000). Protein complexes activate distinct caspase cascades in death receptor and stress induced apoptosis. Experimental Cell Research, 256(1), 27–33. 10.1006/excr.2000.4835
  • Dimova, M., Tugai, A., Tugai, T., Iutynska, G., Dordevic, D., & Kushkevych, I. (2022). Molecular research of lipid peroxidation and antioxidant enzyme activity of comamonas testosteroni bacterial cells under the hexachlorobenzene impact. International Journal of Molecular Sciences, 23(19), 1-11. 10.3390/ijms231911415
  • Dirican, E., Ozcan, H., Uzunçakmak S.K. & Takim U. (2023) Evaluation expression of the caspase-3 and caspase-9 apoptotic genes in schizophrenia patients. Clinical Psychopharmacology and Neuroscience, 21(1): 171-178. 10.9758/cpn.2023.21.1.171
  • Elkhoely, A. (2023) Liraglutide ameliorates gentamicin-induced acute kidney injury in rats via PGC-1α- mediated mitochondrial biogenesis: Involvement of PKA/CREB and Notch/Hes-1 signaling pathways. International Immunopharmacology, 114, 109578. 10.1016/j.intimp.2022.109578
  • Elmore, S. (2007). Apoptosis: A review of programmed cell death. Toxicologic Pathology, 35(4), 495–516. 10.1080/01926230701320337
  • Geshnigani, S.S.H., Mahdavinia, M., Kalantar, M., Goudarzi, M., Khorsandi, L., & Kalantar H. (2023) Diosmin prophylaxis reduces gentamicin-induced kidney damage in rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 396, 63–71.10.1007/s00210-022-02295-3
  • Hodiamont, C.J., van den Broek, A.K., de Vroom, S.L., Prins J.M., Mathot R.A.A. & van Hest R.M. (2022). Clinical Pharmacokinetics of gentamicin in various patient populations and consequences for optimal dosing for gram-negative infections: an updated review. Clinical Pharmacokinetics, 61, 1075–1094. 10.1007/s40262-022-01143-0
  • Ilhan, F. (2018). Homeopatiyle sağlıklı kalmak. Journal of Traditional and Complementary Medicine, 1(1), 29-34. 10.5336/jtracom.2017-56452
  • Kacar, C., Zonturlu, A.K., Oral, H., Yildiz, S., & Ari, U.C. (2007). İneklerde erken puerperal dönemde theranekron® uygulamalarının uterus involusyonu ve vajinal akıntı üzerine etkisi. Kafkas Universitesi Veteriner Fakültesi Dergisi, 13(1), 11-15. 10.9775/kvfd.2006.36-A
  • Kader, C., Sünbül, M., Daş, Y.K., Yarım, M., Bedir, A., Karaca, E., Celikbilek, M., & Özaras, R. (2017). Telbivudine attenuates gentamicin-induced kidney injury in rats. International Journal of Antimicrobial Agents, 49(5), 595-602. 10.1016/j.ijantimicag.2017.01.015
  • Kalkan, Y., Asena, K., Kapakin, T., Kara, A., Atabay, T., Karadeniz, A., Simsek, N., Karakus, E., Can, I., Yildirim, S., Ozkanlar, S., & Sengul, E. (2012). Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate. Journal of Molecular Histology, 43(5), 603–613. 10.1007/s10735-012-9412-4
  • Karabacak, M., Eraslan, G., Kanbur, M., & Sarıca, Z.S. (2015). Effects of Tarantula cubensis D6 on aflatoxin induced injury in biochemical parameters in rats. Homeopathy, 104(3), 205-210. 10.1016/j.homp.2015.02.005
  • Karabulut, E. (2016). Gentamisinle nefrotoksisite sıçanlarda l-argininin koruyucu etkisinde antioksidan mekanizmaların rolü [Doctoral dissertation University of Çukurova]. https://acikbilim.yok.gov.tr/handle/20.500.12812/124726.
  • Khaksari, M., Esmaili, S., Abedloo, R., & Khastar, H. (2021). Palmatine ameliorates nephrotoxicity and hepatotoxicity induced by gentamicin in rats. Archives of Physiology and Biochemistry, 127(3), 273–278. 10.1080/13813455.2019.1633354
  • Leonard, D.F., Mahamadou, B., Albert, S., Basile, T., Sekou, B. & Bale, B. (2023) Effects of fruits of aqueous extract of Sarcocephalus latifolius b. on gentamicin-induced nephrotoxicity in rats. Journal of Pharmacy and Pharmacology Research, 7(1), 12-19. 10.26502/fjppr.066
  • Li, B., Li, N., Wang, N., Li, C., Liu, X., Cao, Z., Xing, C. & Wang, S. (2023) Targeting ROS-sensitive TRP ion channels for relieving oxidative stress-related diseases based on nanomaterials. Materials Today Advances, 17,1-19. 10.1016/j.mtadv.2022.100335
  • Li, M., Maderdrut, J.L., Lertora, J.J., Arimura, A., & Batuman, V. (2008). Renoprotection by pituitary adenylate cyclase activating polypeptide in multiple myeloma and other kidney diseases. Regulatory Peptides, 145(1-3), 24-32. 10.1016/j.regpep.2007.09.012
  • Lotfollahzadeh, S., Alizadeh, M.R., Mohri, M., & Mokhber-Dezfouli, M.R. (2012). The therapeutic effect of Tarantula cubensis Extract (Theranekron(R)) in foot and mouth disease in cattle: a randomised trial in an endemic setting. Homeopathy, 101(3), 159-164. 10.1016/j.homp.2012.05.008
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., & Randall, R.J. (1951). Protein Measurement with folin phenol reagent. Journal of Biological Chemistry, 193, 265-75.
  • Mak, T. (2003). The E. Donnall Thomas lecture apoptosis: "This death that makes life live". Biology of Blood and Marrow Transplantation, 9, 483-488. 10.1016/S1083-8791(03)00215-5
  • Memisogullari, R. (2005). The role of free radicals and the effect of antioxidants in diabetes. Düzce Tıp Fakültesi Dergisi, 3, 30-39.
  • Nadeem R.I., Aboutaleb A.S., Younis N.S., Ahmed H.I. (2023) Diosmin Mitigates Gentamicin-Induced Nephrotoxicity in Rats: Insights on miR-21 and -155 Expression, Nrf2/HO-1 and p38-MAPK/NF-κB Pathways. Toxics, 11, 48. 10.3390/toxics11010048
  • Ozbek, S.S. (2019). Sıçan böbrek iskemi reperfüzyon modelinde Tarantula cubensis ekstraktının etkileri. [Doctoral dissertation University of Atatürk]. https://acikbilim.yok.gov.tr/handle/20.500.12812/54332.
  • Ozsayin, G.H. (2019). Gentamisin ile sıçanlarda oluşturulan nefrotoksisite üzerinde Cyclotrichium niveum ekstresinin koruyucu etkisi. [Master dissertation University of Cukurova]. https://acikbilim.yok.gov.tr/handle/20.500.12812/123637.
  • Puppel, K., Kapusta, A., & Kuczynska, B. (2015). The etiology of oxidative stress in the various species of animals. Journal of the Science of Food and Agriculture, 95(11), 2179-2184. 10.1002/jsfa.7015
  • Rizwana, K., Mohammad, A., Shah, C.S., Fahamiya, N. & Shiffa, M. (2022). Nephroprotective activity of the hydro-alcoholic, ethanolic extract and its fractions of tukhme soya (Anethum sowa Roxb.) against gentamicin induced nephrotoxicity in albino rats. Journal of Young Pharmacists, 14(1), 50-55. 10.5530/jyp.2022.14.10
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There are 53 citations in total.

Details

Primary Language English
Subjects Veterinary Surgery
Journal Section Research Articles
Authors

Caner Eren This is me 0000-0001-7136-1469

Dilek Akşit 0000-0001-6595-7821

Project Number 2019/10
Publication Date June 23, 2023
Submission Date March 11, 2023
Published in Issue Year 2023 Volume: 12 Issue: 1

Cite

APA Eren, C., & Akşit, D. (2023). The Investigation Protective Effect of Tarantula Cubensis Extract in Rats Induced Experimental Gentamicin Nephrotoxicity. Animal Health Production and Hygiene, 12(1), 31-39. https://doi.org/10.53913/aduveterinary.1263745