Research Article
Year 2023,
Volume: 6 Issue: 1, 164 - 169, 28.02.2023
Abstract
Özet
Amaç: Diyabetes mellitusta ortaya çıkan hiperglisemi çeşitli mekanizmalar ile hücresel ve humoral bağışıklık sistemini bozar. Diyabetli hastalarda Covid-19 duyarlılığı artmıştır. C-reaktif protein (CRP) ve albümin seviyeleri çeşitli infeksiyon ve inflamasyon durumlarından etkilenmektedir. Son yıllarda CRP/albümin oranı yeni bir prognostik skor olarak kullanılmaktadır. Çalışmamızda diyabeti olan ve olmayan Covid-19 hastalarında CRP, albümin ve CRP/albümin oranlarını araştırarak hastalık şiddeti açısından fark olup olmadığını saptamayı amaçladık.
Materyal ve metot: Çalışmaya Covid-19 tanılı 40 diyabeti olan, 32 diyabet tanısı olmayan hastalar dahil edildi. Romatolojik hastalık, kanser ve organ yetmezliği, gebe, Covid-19 dışında eşlik eden enfeksiyonu olanlar dahil edilmedi. Çalışmaya dahil edilenlerin kayıtları geçmişe yönelik olarak taranarak cinsiyet, yaş, CRP, albümin, lökosit, lenfosit, nötrofil, platelet, hemoglobin, MPV değerleri kaydedildi.
Bulgular: Ortalama CRP düzeyi diyabeti olan grupta (6.54 ± 4.12 mg/dl) diyabeti olmayan gruba göre (2.94 ± 2.50 mg/dl) anlamlı şekilde yüksek bulundu (p<0.001). Ortalama CRP/albümin oranı diyabeti olan grupta (1.76 ± 1.21) diyabeti olmayan gruba göre (0.75 ± 0.64) anlamlı yüksekti (p<0.001). Ortalama albümin düzeyi açısından diyabeti olan grup (3.89 ± 0.43 g/dl) ve diyabeti olmayan grup (4.05 ± 0.38 g/dl) arasında anlamlı fark saptanmadı (p:0.11).
Sonuç: CRP/albümin oranı enfeksiyon şiddetini gösteren bir belirteç olarak sıklıkla kullanılmaktadır. Ancak Covid-19 hastalığının diyabeti olan ve olmayan kişilerde şiddetini göstermek için CRP değerinden daha üstün olduğu gösterilememiştir. Diyabet hastalığı olanlarda Covid-19 enfeksiyonu daha fazla akut faz reaktanı yanıtı oluşturmaktadır.
Anahtar kelimeler: Diyabet, Covid-19, CRP, albümin, CRP/albümin oranı
Keywords
References
- 1. DiabetesCanadaClinicalPracticeGuidelinesExpertCommittee, Punthakee Z, Goldenberg R, Katz P. Definition, ClassificationandDiagnosis of Diabetes, PrediabetesandMetabolicSyndrome. Can J Diabetes. Nisan 2018;42 Suppl1:10-5.
- 2. Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R. Type 2 DiabetesanditsImpact on theImmuneSystem. CurrDiabetesRev. 2020;16(5):442-9.
- 3. Varikasuvu SR, Dutt N, Thangappazham B, Varshney S. Diabetesand COVID-19: A pooledanalysisrelatedtodiseaseseverityandmortality. Prim CareDiabetes. Şubat 2021;15(1):24-7.
- 4. Muniyappa R, Gubbi S. COVID-19 pandemic, coronaviruses, anddiabetesmellitus. Am J PhysiolEndocrinolMetab. 01 Mayıs 2020;318(5):736-41.
- 5. Rajpal A, Rahimi L, Ismail-Beigi F. Factorsleadingtohighmorbidityandmortality of COVID-19 in patientswithtype 2 diabetes. J Diabetes. Aralık 2020;12(12):895-908.
- 6. Watson J, de Salis I, Hamilton W, Salisbury C. ’I’m fishingreally’--inflammatory marker testing in primarycare: a qualitativestudy. Br J Gen Pract J R Coll Gen Pract. Mart 2016;66(644):200-6.
- 7. Osei-Bimpong A, Meek JH, Lewis SM. ESR or CRP? A comparison of theirclinicalutility. HematolAmstNeth. Ağustos 2007;12(4):353-7.
- 8. Bray C, Bell LN, Liang H, Haykal R, Kaiksow F, Mazza JJ, vd. ErythrocyteSedimentation Rate and C-reactive Protein MeasurementsandTheirRelevance in ClinicalMedicine. WMJ OffPublStateMedSocWis. Aralık 2016;115(6):317-21.
- 9. Moshage HJ, Janssen JA, Franssen JH, Hafkenscheid JC, Yap SH. Study of themolecularmechanism of decreasedliversynthesis of albumin in inflammation. J ClinInvest. Haziran 1987;79(6):1635-41.
- 10. Kaplan M, Ates I, Akpinar MY, Yuksel M, Kuzu UB, Kacar S, vd. Predictivevalue of C-reactive protein/albuminratio in acutepancreatitis. HepatobiliaryPancreatDisInt HBPD INT. 15 Ağustos 2017;16(4):424-30.
- 11. Fairclough E, Cairns E, Hamilton J, Kelly C. Evaluation of a modifiedearlywarningsystemforacutemedicaladmissionsandcomparisonwith C-reactive protein/albuminratio as a predictor of patientoutcome. ClinMedLondEngl. Şubat 2009;9(1):30-3.
- 12. Ernst AA, Weiss SJ, Tracy L-A, Weiss NR. Usefulness of CRP and ESR in predictingsepticjoints. South Med J. Haziran 2010;103(6):522-6.
- 13. Hopstaken RM, Muris JW, Knottnerus JA, Kester AD, Rinkens PE, Dinant GJ. Contributions of symptoms, signs, erythrocytesedimentation rate, and C-reactive protein to a diagnosis of pneumonia in acutelowerrespiratorytractinfection. Br J Gen Pract J R Coll Gen Pract. Mayıs 2003;53(490):358-64.
- 14. Chen W, Zheng KI, Liu S, Yan Z, Xu C, Qiao Z. Plasma CRP level is positivelyassociatedwiththeseverity of COVID-19. AnnClinMicrobiolAntimicrob. 15 Mayıs 2020;19(1):18-9.
- 15. Violi F, Ceccarelli G, Cangemi R, Alessandri F, D’Ettorre G, Oliva A, vd. Hypoalbuminemia, Coagulopathy, andVascularDisease in COVID-19. CircRes. 17 Temmuz 2020;127(3):400-1.
- 16. Aloisio E, Chibireva M, Serafini L, Pasqualetti S, Falvella FS, Dolci A, vd. A ComprehensiveAppraisal of LaboratoryBiochemistryTests as MajorPredictors of COVID-19 Severity. ArchPatholLabMed. 01 Aralık 2020;144(12):1457-64.
- 17. Zhou F-S, Gao N, Sun X, Jiang X-Y, Chen J-J, Mao Q-Q, vd. C-reactive protein/abuminratio is a usefulbiomarkerforpredictingthemucosalhealing in theCrohndisease: A retrospectivestudy. Medicine (Baltimore). 12 Mart 2021;100(10):24925-6.
- 18. Kim MH, Ahn JY, Song JE, Choi H, Ann HW, Kim JK, vd. The C-Reactive Protein/AlbuminRatio as an IndependentPredictor of Mortality in Patientswith Severe SepsisorSepticShockTreatedwithEarlyGoal-DirectedTherapy. PloSOne. 2015;10(7):132109-10.
- 19. Torun A, Çakırca TD, Çakırca G, Portakal RD. Thevalue of C-reactive protein/albumin, fibrinogen/albumin, andneutrophil/lymphocyteratios in predictingtheseverity of CoVID-19. RevAssocMedicaBras 1992. Mart 2021;67(3):431-6.
- 20. Schubert S, Heesemann J. [Infections in diabetesmellitus]. ImmunInfekt. Aralık 1995;23(6):200-4.
- 21. Perschel WT, Langefeld TW, Federlin K. [Susceptibilitytoinfections in diabetes--effects on metabolism]. ImmunInfekt. Aralık 1995;23(6):196-200.
- 22. Muller LM a. J, Gorter KJ, Hak E, Goudzwaard WL, Schellevis FG, Hoepelman IM, vd. [Increased risk of infection in patientswithdiabetesmellitustype 1 or 2]. NedTijdschrGeneeskd. 11 Mart 2006;150(10):549-53.
- 23. Zhu L, She Z-G, Cheng X, Qin J-J, Zhang X-J, Cai J, vd. Association of Blood Glucose Control andOutcomes in Patientswith COVID-19 andPre-existingType 2 Diabetes. Cell Metab. 02 Haziran 2020;31(6):1068-77.
- 24. Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C, vd. Diabetes is a risk factorfortheprogressionandprognosis of COVID-19. DiabetesMetabResRev. 31 Mart 2020;3319-20.
Year 2023,
Volume: 6 Issue: 1, 164 - 169, 28.02.2023
Abstract
References
- 1. DiabetesCanadaClinicalPracticeGuidelinesExpertCommittee, Punthakee Z, Goldenberg R, Katz P. Definition, ClassificationandDiagnosis of Diabetes, PrediabetesandMetabolicSyndrome. Can J Diabetes. Nisan 2018;42 Suppl1:10-5.
- 2. Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R. Type 2 DiabetesanditsImpact on theImmuneSystem. CurrDiabetesRev. 2020;16(5):442-9.
- 3. Varikasuvu SR, Dutt N, Thangappazham B, Varshney S. Diabetesand COVID-19: A pooledanalysisrelatedtodiseaseseverityandmortality. Prim CareDiabetes. Şubat 2021;15(1):24-7.
- 4. Muniyappa R, Gubbi S. COVID-19 pandemic, coronaviruses, anddiabetesmellitus. Am J PhysiolEndocrinolMetab. 01 Mayıs 2020;318(5):736-41.
- 5. Rajpal A, Rahimi L, Ismail-Beigi F. Factorsleadingtohighmorbidityandmortality of COVID-19 in patientswithtype 2 diabetes. J Diabetes. Aralık 2020;12(12):895-908.
- 6. Watson J, de Salis I, Hamilton W, Salisbury C. ’I’m fishingreally’--inflammatory marker testing in primarycare: a qualitativestudy. Br J Gen Pract J R Coll Gen Pract. Mart 2016;66(644):200-6.
- 7. Osei-Bimpong A, Meek JH, Lewis SM. ESR or CRP? A comparison of theirclinicalutility. HematolAmstNeth. Ağustos 2007;12(4):353-7.
- 8. Bray C, Bell LN, Liang H, Haykal R, Kaiksow F, Mazza JJ, vd. ErythrocyteSedimentation Rate and C-reactive Protein MeasurementsandTheirRelevance in ClinicalMedicine. WMJ OffPublStateMedSocWis. Aralık 2016;115(6):317-21.
- 9. Moshage HJ, Janssen JA, Franssen JH, Hafkenscheid JC, Yap SH. Study of themolecularmechanism of decreasedliversynthesis of albumin in inflammation. J ClinInvest. Haziran 1987;79(6):1635-41.
- 10. Kaplan M, Ates I, Akpinar MY, Yuksel M, Kuzu UB, Kacar S, vd. Predictivevalue of C-reactive protein/albuminratio in acutepancreatitis. HepatobiliaryPancreatDisInt HBPD INT. 15 Ağustos 2017;16(4):424-30.
- 11. Fairclough E, Cairns E, Hamilton J, Kelly C. Evaluation of a modifiedearlywarningsystemforacutemedicaladmissionsandcomparisonwith C-reactive protein/albuminratio as a predictor of patientoutcome. ClinMedLondEngl. Şubat 2009;9(1):30-3.
- 12. Ernst AA, Weiss SJ, Tracy L-A, Weiss NR. Usefulness of CRP and ESR in predictingsepticjoints. South Med J. Haziran 2010;103(6):522-6.
- 13. Hopstaken RM, Muris JW, Knottnerus JA, Kester AD, Rinkens PE, Dinant GJ. Contributions of symptoms, signs, erythrocytesedimentation rate, and C-reactive protein to a diagnosis of pneumonia in acutelowerrespiratorytractinfection. Br J Gen Pract J R Coll Gen Pract. Mayıs 2003;53(490):358-64.
- 14. Chen W, Zheng KI, Liu S, Yan Z, Xu C, Qiao Z. Plasma CRP level is positivelyassociatedwiththeseverity of COVID-19. AnnClinMicrobiolAntimicrob. 15 Mayıs 2020;19(1):18-9.
- 15. Violi F, Ceccarelli G, Cangemi R, Alessandri F, D’Ettorre G, Oliva A, vd. Hypoalbuminemia, Coagulopathy, andVascularDisease in COVID-19. CircRes. 17 Temmuz 2020;127(3):400-1.
- 16. Aloisio E, Chibireva M, Serafini L, Pasqualetti S, Falvella FS, Dolci A, vd. A ComprehensiveAppraisal of LaboratoryBiochemistryTests as MajorPredictors of COVID-19 Severity. ArchPatholLabMed. 01 Aralık 2020;144(12):1457-64.
- 17. Zhou F-S, Gao N, Sun X, Jiang X-Y, Chen J-J, Mao Q-Q, vd. C-reactive protein/abuminratio is a usefulbiomarkerforpredictingthemucosalhealing in theCrohndisease: A retrospectivestudy. Medicine (Baltimore). 12 Mart 2021;100(10):24925-6.
- 18. Kim MH, Ahn JY, Song JE, Choi H, Ann HW, Kim JK, vd. The C-Reactive Protein/AlbuminRatio as an IndependentPredictor of Mortality in Patientswith Severe SepsisorSepticShockTreatedwithEarlyGoal-DirectedTherapy. PloSOne. 2015;10(7):132109-10.
- 19. Torun A, Çakırca TD, Çakırca G, Portakal RD. Thevalue of C-reactive protein/albumin, fibrinogen/albumin, andneutrophil/lymphocyteratios in predictingtheseverity of CoVID-19. RevAssocMedicaBras 1992. Mart 2021;67(3):431-6.
- 20. Schubert S, Heesemann J. [Infections in diabetesmellitus]. ImmunInfekt. Aralık 1995;23(6):200-4.
- 21. Perschel WT, Langefeld TW, Federlin K. [Susceptibilitytoinfections in diabetes--effects on metabolism]. ImmunInfekt. Aralık 1995;23(6):196-200.
- 22. Muller LM a. J, Gorter KJ, Hak E, Goudzwaard WL, Schellevis FG, Hoepelman IM, vd. [Increased risk of infection in patientswithdiabetesmellitustype 1 or 2]. NedTijdschrGeneeskd. 11 Mart 2006;150(10):549-53.
- 23. Zhu L, She Z-G, Cheng X, Qin J-J, Zhang X-J, Cai J, vd. Association of Blood Glucose Control andOutcomes in Patientswith COVID-19 andPre-existingType 2 Diabetes. Cell Metab. 02 Haziran 2020;31(6):1068-77.
- 24. Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C, vd. Diabetes is a risk factorfortheprogressionandprognosis of COVID-19. DiabetesMetabResRev. 31 Mart 2020;3319-20.
There are 24 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Endocrinology |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | February 28, 2023 |
| Submission Date | June 8, 2022 |
| Acceptance Date | November 7, 2022 |
| Published in Issue | Year 2023 Volume: 6 Issue: 1 |
The articles in the Journal of "Acta Medica Nicomedia" are open access articles licensed under a Creative Commons Attribution-ShareAlike 4.0 International License at the web address https://dergipark.org.tr/tr/pub/actamednicomedia