Research Article
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Year 2023, Volume: 5 Issue: 4, 518 - 525, 27.10.2023

Gülhan Yılmaz Gökmen Canan Demir

https://doi.org/10.38053/acmj.1366947

Abstract

References

  • Venkatesan P. GOLD COPD report: 2023 update. Lancet Respir Med. 2023;11(1):18.
  • Vanfleteren L, Spruit MA, Wouters EFM, Franssen FME. Management of chronic obstructive pulmonary disease beyond the lungs. Lancet Respir Med. 2016;4(11):911-924. doi: 10.1016/s2213-2600(16)00097-7.
  • Decramer M, Janssens W. Chronic obstructive pulmonary disease and comorbidities. Lancet Respir Med. 2013;1(1):73-83. doi: 10.1016/s2213-2600(12)70060-7.
  • Seymour JM, Spruit MA, Hopkinson NS, et al. The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J. 2010;36(1):81-88. doi: 10.1183/09031936.00104909.
  • Barberan-Garcia A, Munoz PA, Gimeno-Santos E, et al. Training-induced changes on quadriceps muscle oxygenation measured by near-infrared spectroscopy in healthy subjects and in chronic obstructive pulmonary disease patients. Clin Physiol Funct Imaging. 2019;39(4):284-290. doi: 10.1111/cpf.12572.
  • Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013;188(8):e13-64. doi: 10.1164/rccm.201309-1634ST.
  • Maltais F, Decramer M, Casaburi R, et al. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;189(9):e15-62. doi: 10.1164/rccm.201402-0373ST.
  • Meyer A, Zoll J, Charles AL, et al. Skeletal muscle mitochondrial dysfunction during chronic obstructive pulmonary disease: central actor and therapeutic target. Exp Physiol. 2013;98(6):1063-1078. doi: 10.1113/expphysiol.2012.069468.
  • O’Donnell DE. Ventilatory limitations in chronic obstructive pulmonary disease. Med Sci Sports Exerc. 2001;33(7 Suppl):S647-655. doi: 10.1097/00005768-200107001-00002.
  • O’Donnell DE, Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164(5):770-777. doi: 10.1164/ajrccm.164.5.2012122.
  • Maltais F, Jobin J, Sullivan MJ, et al. Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD. J Appl Physiol (1985). 1998;84(5):1573-1580. doi: 10.1152/jappl.1998.84.5.1573.
  • Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med. 2017;195(5):557-582. doi: 10.1164/rccm.201701-0218PP.
  • de Torres JP, Pinto-Plata V, Ingenito E, et al. Power of outcome measurements to detect clinically significant changes in pulmonary rehabilitation of patients with COPD. Chest. 2002;121(4):1092-1098. doi: 10.1378/chest.121.4.1092.
  • Louvaris Z, Kortianou EA, Spetsioti S, et al. Intensity of daily physical activity is associated with central hemodynamic and leg muscle oxygen availability in COPD. J Appl Physiol (1985). 2013;115(6):794-802. doi: 10.1152/japplphysiol.00379.2013.
  • Gephine S, Mucci P, Bielmann M, et al. Quadriceps physiological response during the 1-min sit-to-stand test in people with severe COPD and healthy controls. Sci Rep. 2022;12(1):794. doi: 10.1038/s41598-022-04820-z.
  • Louvaris Z, Habazettl H, Asimakos A, et al. Heterogeneity of blood flow and metabolism during exercise in patients with chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 2017;237:42-50. doi: 10.1016/j.resp.2016.12.013.
  • Puente-Maestu L, SantaCruz A, Vargas T, Martínez-Abad Y, Whipp BJ. Effects of training on the tolerance to high-intensity exercise in patients with severe COPD. Respiration. 2003;70(4):367-370. doi: 10.1159/000072899.
  • Hamaoka T, McCully KK, Quaresima V, Yamamoto K, Chance B. Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans. J Biomed Opt. 2007;12(6):062105. doi: 10.1117/1.2805437.
  • Mahler DA, Wells CK. Evaluation of clinical methods for rating dyspnea. Chest. 1988;93(3):580-586. doi: 10.1378/chest.93.3.580.
  • Mahler DA, Ward J, Waterman LA, McCusker C, ZuWallack R, Baird JC. Patient-reported dyspnea in COPD reliability and association with stage of disease. Chest. 2009;136(6):1473-1479. doi: 10.1378/chest.09-0934.
  • Yorgancıoğlu A, Polatlı M, Aydemir Ö, et al. Reliability and validity of Turkish version of COPD assessment test. Tuberk Toraks. 2012;60(4):314-320. doi: 10.5578/tt.4321.
  • Stanojevic S, Kaminsky DA, Miller MR, et al. ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J. 2022;60(1). doi: 10.1183/13993003.01499-2021.
  • Crum EM, O’Connor WJ, Van Loo L, Valckx M, Stannard SR. Validity and reliability of the Moxy oxygen monitor during incremental cycling exercise. Eur J Sport Sci. 2017;17(8):1037-1043. doi: 10.1080/17461391.2017.1330899.
  • Bohannon RW. Make tests and break tests of elbow flexor muscle strength. Phys Ther. 1988;68(2):193-194. doi: 10.1093/ptj/68.2.193.
  • Stratford PW, Balsor BE. A comparison of make and break tests using a hand-held dynamometer and the Kin-Com. J Orthop Sports Phys Ther. 1994;19(1):28-32. doi: 10.2519/jospt.1994.19.1.28.
  • Roy MA, Doherty TJ. Reliability of hand-held dynamometry in assessment of knee extensor strength after hip fracture. Am J Phys Med Rehabil. 2004;83(11):813-818. doi: 10.1097/01.phm.0000143405.17932.78.
  • Görmel S, Yaşar S, Asil S, et al. Characteristics of a large-scale cohort with accessory pathway(s): A cross-sectional retrospective study highlighting over a twenty-year experience. Turk Kardiyol Dern Ars. 2021;49(6):456-462. doi: 10.5543/tkda.2021.90388.
  • Brooks D, Solway S, Gibbons WJ. ATS statement on six-minute walk test. Am J Respir Crit Care Med. 2003;167(9):1287. doi: 10.1164/ajrccm.167.9.950.
  • Wakasugi T, Morishita S, Kaida K, et al. Impaired skeletal muscle oxygenation following allogeneic hematopoietic stem cell transplantation is associated with exercise capacity. Support Care Cancer. 2018;26(7):2149-2160. doi: 10.1007/s00520-017-4036-6.
  • Szucs B, Petrekanits M, Fekete M, Varga JT. The use of near-infrared spectroscopy for the evaluation of a 4-week rehabilitation program in patients with COPD. Physiol Int. 2021. doi: 10.1556/2060.2021.00185.
  • Ehrman J, Gordon, PM, Visich, PS, Keteyian SJ, eds. . Book Review: Clinical Exercise Physiology. Berlin AA: Champaign, IL: Human Kinetics Publishers; 2003.
  • Murthy G, Hargens AR, Lehman S, Rempel DM. Ischemia causes muscle fatigue. J Orthop Res. 2001;19(3):436-440. doi: 10.1016/s0736-0266(00)90019-6.
  • Ünal KS, Tar E, Kant E, Çetinkaya F. The effect of walking exercise on oxygen saturation, dyspnea and happiness in COPD patients. J Curr Res Health Sector. 2018;8(1):95-110.
  • Sarpkaya Ü, Tuna H, Altiay G, Tabakoğlu E. Kronik obstrüktif akciğer hastaliğinda solunum kaslari egzersizlerinin ve aerobik egzersiz programinin solunum fonksiyon testlerine ve arter kan gazi değerlerine etkisi. Arch Rheumatol. 2004;19 (3).
  • Tateishi Y, Yoshikawa T, Kanazawa H, et al. Evaluation of peripheral muscle oxygenation during exercise by spatially resolved spectroscopy in patients with chronic obstructive pulmonary disease. Osaka City Med J. 2005;51(2):65-72.
  • Tateishi Y, Yoshikawa T, Kanazawa H, et al. Evaluation of peripheral muscle oxygenation during exercise by spatially resolved spectroscopy in patients with chronic obstructive pulmonary disease. Osaka City Medical Journal. 2005;51(2):65.
  • Serres I, Hayot M, Préfaut C, Mercier J. Skeletal muscle abnormalities in patients with COPD: contribution to exercise intolerance. Med Sci Sports Exerc. 1998;30(7):1019-1027. doi: 10.1097/00005768-199807000-00001.
  • Maltais F, LeBlanc P, Jobin J, Casaburi R. Peripheral muscle dysfunction in chronic obstructive pulmonary disease. Clin Chest Med. 2000;21(4):665-677. doi: 10.1016/s0272-5231(05)70176-3.
  • Okamoto T, Kanazawa H, Hirata K, Yoshikawa J. Evaluation of oxygen uptake kinetics and oxygen kinetics of peripheral skeletal muscle during recovery from exercise in patients with chronic obstructive pulmonary disease. Clin Physiol Funct Imaging. 2003;23(5):257-262. doi: 10.1046/j.1475-097x.2003.00500.x.

Effects of chronic obstructive pulmonary disease stage on muscle oxygenation during exercise

Year 2023, Volume: 5 Issue: 4, 518 - 525, 27.10.2023

Gülhan Yılmaz Gökmen Canan Demir

https://doi.org/10.38053/acmj.1366947

Abstract

Aims: The aim of this study was to investigate peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD) at rest, during submaximal exercise, and during recovery, and to determine the effects of disease stage on peripheral muscle oxygenation.
Methods: Of the 35 stable COPD patients (62.49±8.45 years), 18 patients in GOLD 1 and 2 were assigned to Group 1 and 17 patients in GOLD 3 and 4 were assigned to Group 2. Dyspnea perception of the patients was evaluated with the Modified Medical Research Council (mMRC) Dyspnea Scale, severity of the disease affecting daily life was evaluated with the COPD Assessment Test (CAT-COPD Assessment Test), respiratory function was evaluated with the Pulmonary Function Test, and quadriceps muscle strength was evaluated with a manual muscle testing device. Muscle oxygenation of the patients was measured with Near-infrared spectroscopy (NIRS) for 5 minutes at rest, 6 minutes during the 6-Minute Walk Test (6-MWT), and 5 minutes during recovery after the end of the test. The results of the two groups were compared.
Results: Intragroup comparisons of muscle oxygenation at rest, during 6-MWT and during recovery; in Group 1, there was a statistically significant decrease between resting SmO2 mean and test SmO2 mean (p=0.001), a increase between test SmO2 mean and recovery SmO2 mean (p<0.001), and a significant increase between resting SmO2 mean and recovery SmO2 mean (p=0.022). In Group 2, there was a statistically significant decrease between resting SmO2 mean and SmO2 mean during the test (p=0.002), increase between resting SmO2 mean and recovery SmO2 mean (p<0.001*), and resting SmO2 mean and recovery SmO2 mean (p=0.024). There was no significant difference between the groups in Δ Rest-Test SmO2mean, Δ Recovery-Test SmO2mean, and Δ Recovery-Rest SmO2mean (p>0.05). In the SmO2 comparison of Group 1 and Group 2 at rest, during 6-MWT, and during recovery, it was observed that the test SmO2mean value was statistically higher in Group 2 (p=0.023).
Conclusion: When the disease stage increases in individuals with COPD, muscle oxygen utilization metabolism during submaximal exercise worsens, demanding more oxygen to the muscle to produce the same movement as in individuals with a lower disease stage. This may be explained by the fact that energy metabolism and endurance are affected due to the decrease in the oxygen level of the muscle and its capacity to utilize the available oxygen with increasing disease severity.

Keywords

COPD near infrared spectrometry severity submaximal test

Ethical Statement

This study was approved by Bandırma Onyedi Eylul University Health Sciences Non-Interventional Research Ethics Committee (Ethics Committee No: 2023-72) and registered at ClinicalTrials.gov (Identifier: NCT06041126). The study was conducted according to the principles of the Declaration of Helsinki. Informed Consent: All patients signed the free and informed consent form.

Supporting Institution

None

Thanks

As the authors, we would like to thank the Assoc. Prof. Dilber Durmaz, pulmonologist at the department of pulmonology Bandırma Training and Research Hospital, who supported our data collection.

References

  • Venkatesan P. GOLD COPD report: 2023 update. Lancet Respir Med. 2023;11(1):18.
  • Vanfleteren L, Spruit MA, Wouters EFM, Franssen FME. Management of chronic obstructive pulmonary disease beyond the lungs. Lancet Respir Med. 2016;4(11):911-924. doi: 10.1016/s2213-2600(16)00097-7.
  • Decramer M, Janssens W. Chronic obstructive pulmonary disease and comorbidities. Lancet Respir Med. 2013;1(1):73-83. doi: 10.1016/s2213-2600(12)70060-7.
  • Seymour JM, Spruit MA, Hopkinson NS, et al. The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J. 2010;36(1):81-88. doi: 10.1183/09031936.00104909.
  • Barberan-Garcia A, Munoz PA, Gimeno-Santos E, et al. Training-induced changes on quadriceps muscle oxygenation measured by near-infrared spectroscopy in healthy subjects and in chronic obstructive pulmonary disease patients. Clin Physiol Funct Imaging. 2019;39(4):284-290. doi: 10.1111/cpf.12572.
  • Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013;188(8):e13-64. doi: 10.1164/rccm.201309-1634ST.
  • Maltais F, Decramer M, Casaburi R, et al. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;189(9):e15-62. doi: 10.1164/rccm.201402-0373ST.
  • Meyer A, Zoll J, Charles AL, et al. Skeletal muscle mitochondrial dysfunction during chronic obstructive pulmonary disease: central actor and therapeutic target. Exp Physiol. 2013;98(6):1063-1078. doi: 10.1113/expphysiol.2012.069468.
  • O’Donnell DE. Ventilatory limitations in chronic obstructive pulmonary disease. Med Sci Sports Exerc. 2001;33(7 Suppl):S647-655. doi: 10.1097/00005768-200107001-00002.
  • O’Donnell DE, Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164(5):770-777. doi: 10.1164/ajrccm.164.5.2012122.
  • Maltais F, Jobin J, Sullivan MJ, et al. Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD. J Appl Physiol (1985). 1998;84(5):1573-1580. doi: 10.1152/jappl.1998.84.5.1573.
  • Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med. 2017;195(5):557-582. doi: 10.1164/rccm.201701-0218PP.
  • de Torres JP, Pinto-Plata V, Ingenito E, et al. Power of outcome measurements to detect clinically significant changes in pulmonary rehabilitation of patients with COPD. Chest. 2002;121(4):1092-1098. doi: 10.1378/chest.121.4.1092.
  • Louvaris Z, Kortianou EA, Spetsioti S, et al. Intensity of daily physical activity is associated with central hemodynamic and leg muscle oxygen availability in COPD. J Appl Physiol (1985). 2013;115(6):794-802. doi: 10.1152/japplphysiol.00379.2013.
  • Gephine S, Mucci P, Bielmann M, et al. Quadriceps physiological response during the 1-min sit-to-stand test in people with severe COPD and healthy controls. Sci Rep. 2022;12(1):794. doi: 10.1038/s41598-022-04820-z.
  • Louvaris Z, Habazettl H, Asimakos A, et al. Heterogeneity of blood flow and metabolism during exercise in patients with chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 2017;237:42-50. doi: 10.1016/j.resp.2016.12.013.
  • Puente-Maestu L, SantaCruz A, Vargas T, Martínez-Abad Y, Whipp BJ. Effects of training on the tolerance to high-intensity exercise in patients with severe COPD. Respiration. 2003;70(4):367-370. doi: 10.1159/000072899.
  • Hamaoka T, McCully KK, Quaresima V, Yamamoto K, Chance B. Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans. J Biomed Opt. 2007;12(6):062105. doi: 10.1117/1.2805437.
  • Mahler DA, Wells CK. Evaluation of clinical methods for rating dyspnea. Chest. 1988;93(3):580-586. doi: 10.1378/chest.93.3.580.
  • Mahler DA, Ward J, Waterman LA, McCusker C, ZuWallack R, Baird JC. Patient-reported dyspnea in COPD reliability and association with stage of disease. Chest. 2009;136(6):1473-1479. doi: 10.1378/chest.09-0934.
  • Yorgancıoğlu A, Polatlı M, Aydemir Ö, et al. Reliability and validity of Turkish version of COPD assessment test. Tuberk Toraks. 2012;60(4):314-320. doi: 10.5578/tt.4321.
  • Stanojevic S, Kaminsky DA, Miller MR, et al. ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J. 2022;60(1). doi: 10.1183/13993003.01499-2021.
  • Crum EM, O’Connor WJ, Van Loo L, Valckx M, Stannard SR. Validity and reliability of the Moxy oxygen monitor during incremental cycling exercise. Eur J Sport Sci. 2017;17(8):1037-1043. doi: 10.1080/17461391.2017.1330899.
  • Bohannon RW. Make tests and break tests of elbow flexor muscle strength. Phys Ther. 1988;68(2):193-194. doi: 10.1093/ptj/68.2.193.
  • Stratford PW, Balsor BE. A comparison of make and break tests using a hand-held dynamometer and the Kin-Com. J Orthop Sports Phys Ther. 1994;19(1):28-32. doi: 10.2519/jospt.1994.19.1.28.
  • Roy MA, Doherty TJ. Reliability of hand-held dynamometry in assessment of knee extensor strength after hip fracture. Am J Phys Med Rehabil. 2004;83(11):813-818. doi: 10.1097/01.phm.0000143405.17932.78.
  • Görmel S, Yaşar S, Asil S, et al. Characteristics of a large-scale cohort with accessory pathway(s): A cross-sectional retrospective study highlighting over a twenty-year experience. Turk Kardiyol Dern Ars. 2021;49(6):456-462. doi: 10.5543/tkda.2021.90388.
  • Brooks D, Solway S, Gibbons WJ. ATS statement on six-minute walk test. Am J Respir Crit Care Med. 2003;167(9):1287. doi: 10.1164/ajrccm.167.9.950.
  • Wakasugi T, Morishita S, Kaida K, et al. Impaired skeletal muscle oxygenation following allogeneic hematopoietic stem cell transplantation is associated with exercise capacity. Support Care Cancer. 2018;26(7):2149-2160. doi: 10.1007/s00520-017-4036-6.
  • Szucs B, Petrekanits M, Fekete M, Varga JT. The use of near-infrared spectroscopy for the evaluation of a 4-week rehabilitation program in patients with COPD. Physiol Int. 2021. doi: 10.1556/2060.2021.00185.
  • Ehrman J, Gordon, PM, Visich, PS, Keteyian SJ, eds. . Book Review: Clinical Exercise Physiology. Berlin AA: Champaign, IL: Human Kinetics Publishers; 2003.
  • Murthy G, Hargens AR, Lehman S, Rempel DM. Ischemia causes muscle fatigue. J Orthop Res. 2001;19(3):436-440. doi: 10.1016/s0736-0266(00)90019-6.
  • Ünal KS, Tar E, Kant E, Çetinkaya F. The effect of walking exercise on oxygen saturation, dyspnea and happiness in COPD patients. J Curr Res Health Sector. 2018;8(1):95-110.
  • Sarpkaya Ü, Tuna H, Altiay G, Tabakoğlu E. Kronik obstrüktif akciğer hastaliğinda solunum kaslari egzersizlerinin ve aerobik egzersiz programinin solunum fonksiyon testlerine ve arter kan gazi değerlerine etkisi. Arch Rheumatol. 2004;19 (3).
  • Tateishi Y, Yoshikawa T, Kanazawa H, et al. Evaluation of peripheral muscle oxygenation during exercise by spatially resolved spectroscopy in patients with chronic obstructive pulmonary disease. Osaka City Med J. 2005;51(2):65-72.
  • Tateishi Y, Yoshikawa T, Kanazawa H, et al. Evaluation of peripheral muscle oxygenation during exercise by spatially resolved spectroscopy in patients with chronic obstructive pulmonary disease. Osaka City Medical Journal. 2005;51(2):65.
  • Serres I, Hayot M, Préfaut C, Mercier J. Skeletal muscle abnormalities in patients with COPD: contribution to exercise intolerance. Med Sci Sports Exerc. 1998;30(7):1019-1027. doi: 10.1097/00005768-199807000-00001.
  • Maltais F, LeBlanc P, Jobin J, Casaburi R. Peripheral muscle dysfunction in chronic obstructive pulmonary disease. Clin Chest Med. 2000;21(4):665-677. doi: 10.1016/s0272-5231(05)70176-3.
  • Okamoto T, Kanazawa H, Hirata K, Yoshikawa J. Evaluation of oxygen uptake kinetics and oxygen kinetics of peripheral skeletal muscle during recovery from exercise in patients with chronic obstructive pulmonary disease. Clin Physiol Funct Imaging. 2003;23(5):257-262. doi: 10.1046/j.1475-097x.2003.00500.x.
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Details

Primary Language English
Subjects Chest Diseases, Physiotherapy
Journal Section Research Articles
Authors

Gülhan Yılmaz Gökmen 0000-0002-0468-7036

Canan Demir 0000-0002-0891-083X

Publication Date October 27, 2023
Published in Issue Year 2023 Volume: 5 Issue: 4

Cite

AMA Yılmaz Gökmen G, Demir C. Effects of chronic obstructive pulmonary disease stage on muscle oxygenation during exercise. Anatolian Curr Med J / ACMJ / acmj. October 2023;5(4):518-525. doi:10.38053/acmj.1366947
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